hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00004.1
Complex Portal: CPX-14113
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MATN1 | Cartilage matrix protein (Matrilin-1) | 5 | UniProt NCBI |
| VPS33B | Vacuolar protein sorting-associated protein 33B (hVPS33B) | 5 | UniProt NCBI |
| ARG2 | Arginase-2, mitochondrial (EC 3.5.3.1) (Arginase II) (Kidney-type arginase) (Non-hepatic arginase) (Type II arginase) | 5 | UniProt NCBI |
| VIPAS39 | Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) | 5 | UniProt NCBI |
| MATN4 | Matrilin-4 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6390 | 1.36501667663e-05 | 0.4 | VPS33B VIPAS39 | Endosomal targeting complex (VIPAS39-VPS33B) |
| HP:0200084 | 0.000384717178033 | 0.4 | VPS33B VIPAS39 | Giant cell hepatitis |
| HP:0009806 | 0.000961529670085 | 0.4 | VPS33B VIPAS39 | Nephrogenic diabetes insipidus |
| HP:0001884 | 0.00288300984678 | 0.4 | VPS33B VIPAS39 | Talipes calcaneovalgus |
| HP:0002611 | 0.00768171284681 | 0.4 | VPS33B VIPAS39 | Cholestatic liver disease |
| HP:0001667 | 0.0191806250585 | 0.4 | VPS33B VIPAS39 | Right ventricular hypertrophy |
| HP:0002908 | 0.0191806250585 | 0.4 | VPS33B VIPAS39 | Conjugated hyperbilirubinemia |
| REAC:R-HSA-3000178 | 0.0249357389386 | 0.4 | MATN1 MATN4 | ECM proteoglycans |
| GO:0120216 | 0.0280843539964 | 0.4 | MATN1 MATN4 | matrilin complex |
| HP:0001947 | 0.0425110382594 | 0.4 | VPS33B VIPAS39 | Renal tubular acidosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MATN1 | MATN4 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| VIPAS39 | MATN4 | 0.985 |
mutually_exclusive (Q9H267)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| VPS33B | MATN4 | 0.981 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ARG2 | MATN4 | 0.96 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| VPS33B | VIPAS39 | 0.957 | 0.774 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ARG2 | VIPAS39 | 0.198 | 0.024 | bioplex_WMM bioplex3_WMM WMM_only | |
| MATN1 | VPS33B | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MATN1 | VIPAS39 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MATN1 | ARG2 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| VPS33B | ARG2 | 0.142 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes