hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00015.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CHTF18 | Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12) | 5 | UniProt NCBI |
| DSCC1 | Sister chromatid cohesion protein DCC1 (Defective in sister chromatid cohesion protein 1 homolog) | 5 | UniProt NCBI |
| CHTF8 | Chromosome transmission fidelity protein 8 homolog (hCTF8) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:612 | 2.33868713081e-10 | 1.0 | CHTF18 DSCC1 CHTF8 | CTF18-CTF8-DCC1 complex |
| CORUM:2806 | 2.33868713081e-10 | 1.0 | CHTF18 DSCC1 CHTF8 | CTF18-CTF8-DCC1 complex |
| CORUM:613 | 9.35474852325e-10 | 1.0 | CHTF18 DSCC1 CHTF8 | CTF18-CTF8-DCC1-RFC3 complex |
| CORUM:2804 | 8.18540495785e-09 | 1.0 | CHTF18 DSCC1 CHTF8 | CTF18-cohesion-RFC complex |
| CORUM:3070 | 1.30966479326e-08 | 1.0 | CHTF18 DSCC1 CHTF8 | CTF18-cohesion-RFC-POLH complex |
| WP:WP2363 | 2.53942947231e-07 | 1.0 | CHTF18 DSCC1 CHTF8 | Gastric cancer network 2 |
| REAC:R-HSA-174411 | 1.21316556698e-06 | 1.0 | CHTF18 DSCC1 CHTF8 | Polymerase switching on the C-strand of the telomere |
| REAC:R-HSA-174417 | 2.79214721263e-06 | 1.0 | CHTF18 DSCC1 CHTF8 | Telomere C-strand (Lagging Strand) Synthesis |
| CORUM:2805 | 3.41752350426e-06 | 0.666666666667 | DSCC1 CHTF8 | CTF8-DCC1 subcomplex |
| GO:0031390 | 5.38272230028e-06 | 1.0 | CHTF18 DSCC1 CHTF8 | Ctf18 RFC-like complex |
| GO:0003689 | 5.38272230028e-06 | 1.0 | CHTF18 DSCC1 CHTF8 | DNA clamp loader activity |
| GO:1900262 | 8.07408345042e-06 | 1.0 | CHTF18 DSCC1 CHTF8 | regulation of DNA-directed DNA polymerase activity |
| GO:1900264 | 8.07408345042e-06 | 1.0 | CHTF18 DSCC1 CHTF8 | positive regulation of DNA-directed DNA polymerase activity |
| REAC:R-HSA-180786 | 9.7169895894e-06 | 1.0 | CHTF18 DSCC1 CHTF8 | Extension of Telomeres |
| CORUM:6304 | 2.05032700758e-05 | 0.666666666667 | CHTF18 DSCC1 | DDX11-Ctf18-RFC complex |
| REAC:R-HSA-157579 | 7.54495662236e-05 | 1.0 | CHTF18 DSCC1 CHTF8 | Telomere Maintenance |
| GO:0017116 | 0.000148024863258 | 1.0 | CHTF18 DSCC1 CHTF8 | single-stranded DNA helicase activity |
| REAC:R-HSA-73886 | 0.000155553488805 | 1.0 | CHTF18 DSCC1 CHTF8 | Chromosome Maintenance |
| GO:0090329 | 0.000878441055398 | 1.0 | CHTF18 DSCC1 CHTF8 | regulation of DNA-templated DNA replication |
| GO:0003678 | 0.00252170927764 | 1.0 | CHTF18 DSCC1 CHTF8 | DNA helicase activity |
| GO:2000573 | 0.00312476641535 | 1.0 | CHTF18 DSCC1 CHTF8 | positive regulation of DNA biosynthetic process |
| GO:0008094 | 0.0120707547584 | 1.0 | CHTF18 DSCC1 CHTF8 | ATP-dependent activity, acting on DNA |
| GO:2000278 | 0.0141719388563 | 1.0 | CHTF18 DSCC1 CHTF8 | regulation of DNA biosynthetic process |
| GO:0006275 | 0.0146194737676 | 1.0 | CHTF18 DSCC1 CHTF8 | regulation of DNA replication |
| REAC:R-HSA-1640170 | 0.0209648611427 | 1.0 | CHTF18 DSCC1 CHTF8 | Cell Cycle |
| GO:0004386 | 0.0219076797621 | 1.0 | CHTF18 DSCC1 CHTF8 | helicase activity |
| GO:0006261 | 0.0439566559847 | 1.0 | CHTF18 DSCC1 CHTF8 | DNA-templated DNA replication |
| GO:0071897 | 0.0458676185213 | 1.0 | CHTF18 DSCC1 CHTF8 | DNA biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DSCC1 | CHTF8 | 1.0 | 0.360666666667 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CHTF18 | DSCC1 | 1.0 | 0.328 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CHTF18 | CHTF8 | 0.979 | 0.37 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes