hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00016.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PDK4 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4) | 5 | UniProt NCBI |
| PDK3 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-204174 | 0.000205051410255 | 1.0 | PDK3 PDK4 | Regulation of pyruvate dehydrogenase (PDH) complex |
| REAC:R-HSA-70268 | 0.000743311362176 | 1.0 | PDK3 PDK4 | Pyruvate metabolism |
| REAC:R-HSA-5362517 | 0.00113803532692 | 1.0 | PDK3 PDK4 | Signaling by Retinoic Acid |
| REAC:R-HSA-71406 | 0.00226581808332 | 1.0 | PDK3 PDK4 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| KEGG:05415 | 0.00267768543767 | 1.0 | PDK3 PDK4 | Diabetic cardiomyopathy |
| GO:0010510 | 0.0028092043205 | 1.0 | PDK3 PDK4 | regulation of acetyl-CoA biosynthetic process from pyruvate |
| GO:0050812 | 0.0028092043205 | 1.0 | PDK3 PDK4 | regulation of acyl-CoA biosynthetic process |
| GO:0004740 | 0.00468200720083 | 1.0 | PDK3 PDK4 | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
| GO:0006086 | 0.0210690324038 | 1.0 | PDK3 PDK4 | acetyl-CoA biosynthetic process from pyruvate |
| GO:0042762 | 0.0210690324038 | 1.0 | PDK3 PDK4 | regulation of sulfur metabolic process |
| REAC:R-HSA-1428517 | 0.0242575818332 | 1.0 | PDK3 PDK4 | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0071398 | 0.0426062655276 | 1.0 | PDK3 PDK4 | cellular response to fatty acid |
| GO:0030808 | 0.0491610756088 | 1.0 | PDK3 PDK4 | regulation of nucleotide biosynthetic process |
| GO:1900371 | 0.0491610756088 | 1.0 | PDK3 PDK4 | regulation of purine nucleotide biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PDK4 | PDK3 | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes