hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_00020.1

Complex Portal: CPX-19600

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
CSRNP1	Cysteine/serine-rich nuclear protein 1 (CSRNP-1) (Axin-1 up-regulated gene 1 protein) (Protein URAX1) (TGF-beta-induced apoptosis protein 3) (TAIP-3)	5	UniProt NCBI
PPP1R2	Protein phosphatase inhibitor 2 (IPP-2)	5	UniProt NCBI
C12orf57	Protein C10	5	UniProt NCBI
C2orf74	Uncharacterized protein C2orf74	2	UniProt NCBI
CCDC85B	Coiled-coil domain-containing protein 85B (Hepatitis delta antigen-interacting protein A) (Delta-interacting protein A)	5	UniProt NCBI
RASSF7	Ras association domain-containing protein 7 (HRAS1-related cluster protein 1)	5	UniProt NCBI
PPP1CB	Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)	5	UniProt NCBI
TANC2	Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2)	5	UniProt NCBI
PPP1R37	Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68)	5	UniProt NCBI
PPP1R13B	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B)	5	UniProt NCBI
CCDC85C	Coiled-coil domain-containing protein 85C	3	UniProt NCBI
PPP1CA	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)	5	UniProt NCBI
SH2D4A	SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38)	5	UniProt NCBI
ZFYVE9	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation)	5	UniProt NCBI
PLCL2	Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2)	5	UniProt NCBI
SHOC2	Leucine-rich repeat protein SHOC-2 (Protein soc-2 homolog) (Protein sur-8 homolog)	5	UniProt NCBI
PPP1R7	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP4861	8.13520722615e-08	0.294117647059	PPP1R13B PPP1CA PPP1R2 PPP1R7 PPP1CB	Endoplasmic reticulum stress response in coronavirus infection
REAC:R-HSA-9726842	0.0114554901828	0.117647058824	PPP1CB SHOC2	Gain-of-function MRAS complexes activate RAF signaling
REAC:R-HSA-9726840	0.0114554901828	0.117647058824	PPP1CB SHOC2	SHOC2 M1731 mutant abolishes MRAS complex function
REAC:R-HSA-9660537	0.0114554901828	0.117647058824	PPP1CB SHOC2	Signaling by MRAS-complex mutants
GO:0000164	0.0362620408935	0.176470588235	PPP1CB SHOC2 PPP1CA	protein phosphatase type 1 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PPP1CB	PPP1CA	1.0	0.556	mutually_exclusive (Q9H788) structurally_consistent (dimer)
RASSF7	PPP1R13B	0.999	0.09	mutually_exclusive (P62140)
PPP1CA	PPP1R7	0.999	0.34	structurally_consistent (dimer)
C12orf57	PPP1CA	0.998	0.024	structurally_consistent (dimer)
TANC2	PPP1CA	0.997	0.19
PPP1CB	PPP1R7	0.996	0.266	mutually_exclusive (Q9GZN8) structurally_consistent (dimer)
SH2D4A	PPP1R7	0.996	0.026	mutually_exclusive (P62136)
PPP1R13B	PPP1CA	0.995	0.136571428571	structurally_consistent (dimer)
PPP1R13B	CCDC85C	0.995	0.138
CCDC85C	PPP1CA	0.995	0.327276099629	mutually_exclusive (P62140) structurally_consistent (dimer)
PPP1CB	SH2D4A	0.995	0.138	structurally_consistent (dimer)
PPP1CA	ZFYVE9	0.994	0.236	structurally_consistent (dimer)
PPP1CB	TANC2	0.992	0.27
CCDC85B	PPP1R13B	0.992	0.124
C12orf57	TANC2	0.992	0.05
CSRNP1	PPP1CA	0.991		mutually_exclusive (P62140) structurally_consistent (dimer)
PPP1CB	PPP1R13B	0.99	0.132	structurally_consistent (dimer)
PPP1CA	SHOC2	0.988	0.144	structurally_consistent (dimer)
RASSF7	PPP1CA	0.988	0.138
PPP1R2	PPP1CB	0.986	0.172	structurally_consistent (dimer)
PPP1CA	SH2D4A	0.983	0.112	structurally_consistent (dimer)
PPP1R2	PPP1CA	0.982	0.204	mutually_exclusive (P62140) structurally_consistent (dimer)
PPP1R2	PPP1R7	0.981	0.128
PPP1CA	PLCL2	0.979	0.332	structurally_consistent (dimer)
CCDC85B	PPP1CA	0.978	0.1412
C2orf74	PPP1CA	0.973		structurally_consistent (dimer)
CCDC85B	CCDC85C	0.972	0.108
PPP1R13B	PPP1R7	0.968	0.098	mutually_exclusive (P62140)
C12orf57	ZFYVE9	0.961	0.048
CSRNP1	PPP1CB	0.958		mutually_exclusive (P62136) structurally_consistent (dimer)
PPP1R37	PPP1CA	0.958	0.182	structurally_consistent (dimer)
C12orf57	PPP1CB	0.949	0.046	structurally_consistent (P62136)
RASSF7	PPP1CB	0.941	0.116	structurally_consistent (dimer)
RASSF7	TANC2	0.899	0.116
RASSF7	ZFYVE9	0.892	0.086	mutually_exclusive (P62140)
PPP1R13B	ZFYVE9	0.88	0.136	mutually_exclusive (P62140)
TANC2	PPP1R13B	0.868	0.122
RASSF7	CCDC85C	0.837	0.182	mutually_exclusive (P62140)
CCDC85C	ZFYVE9	0.837	0.066
TANC2	PPP1R7	0.818	0.062
CSRNP1	PPP1R7	0.816
TANC2	ZFYVE9	0.796	0.052
PPP1R2	TANC2	0.764	0.04
PPP1R2	RASSF7	0.744	0.092	mutually_exclusive (P62140)
TANC2	CCDC85C	0.743	0.062
RASSF7	PPP1R7	0.739	0.084	mutually_exclusive (P62140)
PPP1CB	PLCL2	0.737	0.246
PPP1CB	ZFYVE9	0.71	0.283090909091	structurally_consistent (dimer)
CCDC85B	RASSF7	0.701	0.088
C12orf57	RASSF7	0.676	0.064
PPP1CB	SHOC2	0.649	0.222	structurally_consistent (dimer)
ZFYVE9	PPP1R7	0.629	0.094	mutually_exclusive (P62140)
CCDC85B	ZFYVE9	0.627	0.086
CCDC85B	PPP1R7	0.61	0.028
CCDC85B	SHOC2	0.602	0.146
RASSF7	PLCL2	0.589	0.082
PPP1R37	ZFYVE9	0.58	0.156	mutually_exclusive (P62136)
PPP1R2	CCDC85C	0.57	0.064
CSRNP1	PPP1R37	0.57		mutually_exclusive (P62136)
CSRNP1	C2orf74	0.568		mutually_exclusive (P62136)
C2orf74	PPP1R37	0.568		mutually_exclusive (P62136)
PPP1R2	CCDC85B	0.562	0.06
CCDC85B	PPP1CB	0.557	0.2
PPP1R13B	PLCL2	0.557	0.066	mutually_exclusive (P62136)
RASSF7	SHOC2	0.555	0.086	mutually_exclusive (P62140)
PLCL2	SHOC2	0.555	0.064	mutually_exclusive (P62136)
PPP1R2	SHOC2	0.547	0.066
PPP1CB	CCDC85C	0.546	0.23	structurally_consistent (dimer)
PPP1R13B	SHOC2	0.546	0.126
ZFYVE9	PLCL2	0.536	0.024
CCDC85C	PLCL2	0.526	0.072
PLCL2	PPP1R7	0.526	0.044	structurally_consistent (P62136)
C12orf57	PPP1R7	0.514	0.038	mutually_exclusive (P62136)
C2orf74	TANC2	0.513
C2orf74	PLCL2	0.513		mutually_exclusive (P62136)
TANC2	PPP1R37	0.513	0.16
C2orf74	RASSF7	0.513
C2orf74	ZFYVE9	0.513
C2orf74	SHOC2	0.513		mutually_exclusive (P62136)
ZFYVE9	SHOC2	0.51	0.09	mutually_exclusive (P62140)
C12orf57	CCDC85C	0.492	0.064	structurally_consistent (P62136)
CCDC85C	SH2D4A	0.489	0.08	mutually_exclusive (P62140)
PPP1R37	SHOC2	0.471	0.096	mutually_exclusive (P62136)
RASSF7	PPP1R37	0.471	0.098
CCDC85C	PPP1R7	0.465	0.068
PPP1R37	PLCL2	0.461	0.046	mutually_exclusive (P62136)
PPP1R2	ZFYVE9	0.446	0.114
PPP1R2	PLCL2	0.442	0.028	mutually_exclusive (P62136)
C12orf57	PPP1R13B	0.437	0.072
PPP1R37	PPP1R13B	0.435	0.16	mutually_exclusive (P62136)
PPP1R2	PPP1R13B	0.429	0.08
PPP1R2	C12orf57	0.414	0.042
CCDC85C	SHOC2	0.406	0.05
C12orf57	SHOC2	0.401	0.046	structurally_consistent (P62136)
C12orf57	PLCL2	0.401	0.044	structurally_consistent (P62136)
TANC2	PLCL2	0.4	0.082
CSRNP1	SHOC2	0.396
CSRNP1	ZFYVE9	0.38
CSRNP1	PLCL2	0.378		mutually_exclusive (P62136)
CSRNP1	RASSF7	0.378		mutually_exclusive (P62140)
C2orf74	PPP1R13B	0.378		mutually_exclusive (P62136)
CSRNP1	TANC2	0.377
TANC2	SHOC2	0.367	0.072
PPP1R2	C2orf74	0.364		mutually_exclusive (P62136)
C2orf74	PPP1CB	0.363
CCDC85B	PPP1R37	0.36	0.094
CCDC85B	PLCL2	0.352	0.06
PPP1R2	SH2D4A	0.349	0.032
CCDC85B	TANC2	0.324	0.106
PPP1R37	PPP1R7	0.323	0.114	mutually_exclusive (P62136)
CSRNP1	PPP1R13B	0.289
CSRNP1	CCDC85B	0.27
CSRNP1	PPP1R2	0.27
CSRNP1	CCDC85C	0.244
SHOC2	PPP1R7	0.241	0.11
C2orf74	CCDC85B	0.224
C12orf57	C2orf74	0.214
C12orf57	PPP1R37	0.205	0.084	structurally_consistent (P62136)
CSRNP1	C12orf57	0.205
PPP1R2	PPP1R37	0.2	0.096	mutually_exclusive (P62136)
C12orf57	CCDC85B	0.196	0.078
C2orf74	PPP1R7	0.188
C2orf74	CCDC85C	0.17
PPP1CB	PPP1R37	0.162	0.138
PPP1R37	CCDC85C	0.152	0.108	mutually_exclusive (P62136)
CSRNP1	SH2D4A	0.034
PPP1R37	SH2D4A	0.028	0.09	mutually_exclusive (P62136)
SH2D4A	ZFYVE9	0.028	0.072	mutually_exclusive (P62140)
PPP1R13B	SH2D4A	0.028	0.102
SH2D4A	PLCL2	0.021	0.104	mutually_exclusive (P62136)
CCDC85B	SH2D4A	0.011	0.118

Related Complexes

Genename	Complexes
CSRNP1	huMAP3_00020.1 huMAP3_04660.1 huMAP3_06304.1 huMAP3_06341.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_10148.1 huMAP3_13731.1 huMAP3_14504.1
PPP1R2	huMAP3_00020.1 huMAP3_06341.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_10148.1 huMAP3_14504.1
C12orf57	huMAP3_00020.1 huMAP3_06304.1 huMAP3_07520.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_09903.1 huMAP3_10148.1 huMAP3_12756.1 huMAP3_13598.1 huMAP3_14504.1
C2orf74	huMAP3_00020.1 huMAP3_04660.1 huMAP3_05534.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_10148.1 huMAP3_14504.1
CCDC85B	huMAP3_00020.1 huMAP3_00172.1 huMAP3_06304.1 huMAP3_06341.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_09755.1 huMAP3_10148.1 huMAP3_10901.1 huMAP3_14504.1
RASSF7	huMAP3_00020.1 huMAP3_06304.1 huMAP3_06341.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_09755.1 huMAP3_10148.1 huMAP3_10901.1 huMAP3_14504.1 huMAP3_14915.1
PPP1CB	huMAP3_00020.1 huMAP3_06341.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_10148.1 huMAP3_14504.1
TANC2	huMAP3_00020.1 huMAP3_06304.1 huMAP3_06341.1 huMAP3_06990.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_10148.1 huMAP3_14504.1 huMAP3_15308.1
PPP1R37	huMAP3_00020.1 huMAP3_04660.1 huMAP3_05534.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_10148.1 huMAP3_12339.1 huMAP3_13724.1 huMAP3_13803.1 huMAP3_14504.1
PPP1R13B	huMAP3_00020.1 huMAP3_06304.1 huMAP3_06341.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_09755.1 huMAP3_10148.1 huMAP3_10901.1 huMAP3_14504.1 huMAP3_14934.1
CCDC85C	huMAP3_00020.1 huMAP3_06304.1 huMAP3_06341.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_09755.1 huMAP3_10148.1 huMAP3_10901.1 huMAP3_14504.1
PPP1CA	huMAP3_00020.1 huMAP3_04660.1 huMAP3_05534.1 huMAP3_06304.1 huMAP3_06341.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_10148.1 huMAP3_14504.1
SH2D4A	huMAP3_00020.1 huMAP3_06341.1 huMAP3_07068.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_09861.1 huMAP3_10148.1 huMAP3_12421.1 huMAP3_14504.1
ZFYVE9	huMAP3_00020.1 huMAP3_00500.1 huMAP3_05180.1 huMAP3_06304.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09080.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_10148.1 huMAP3_11389.1 huMAP3_13623.1 huMAP3_14504.1 huMAP3_14587.1
PLCL2	huMAP3_00020.1 huMAP3_01131.1 huMAP3_04472.1 huMAP3_04660.1 huMAP3_06304.1 huMAP3_06341.1 huMAP3_08482.1 huMAP3_09633.1 huMAP3_10148.1 huMAP3_12977.1 huMAP3_14504.1 huMAP3_15010.1
SHOC2	huMAP3_00020.1 huMAP3_04660.1 huMAP3_05534.1 huMAP3_06304.1 huMAP3_06341.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_10148.1 huMAP3_11317.1 huMAP3_12693.1 huMAP3_13348.1 huMAP3_14504.1 huMAP3_15206.1
PPP1R7	huMAP3_00020.1 huMAP3_06341.1 huMAP3_07068.1 huMAP3_07847.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_10148.1 huMAP3_13731.1 huMAP3_14504.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_00020.1

Complex Portal: CPX-19600