hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00022.1
Complex Portal: CPX-15252
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TLE5 | TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator) | 5 | UniProt NCBI |
| RIPPLY1 | Protein ripply1 | 5 | UniProt NCBI |
| TLE4 | Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) | 5 | UniProt NCBI |
| TLE3 | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | 5 | UniProt NCBI |
| TLE2 | Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2) | 5 | UniProt NCBI |
| RIPPLY3 | Protein ripply3 (Down syndrome critical region protein 6) | 5 | UniProt NCBI |
| RIPPLY2 | Protein ripply2 | 5 | UniProt NCBI |
| TLE1 | Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1) | 5 | UniProt NCBI |
| EN1 | Homeobox protein engrailed-1 (Homeobox protein en-1) (Hu-En-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-4641265 | 2.48078851343e-12 | 0.555555555556 | TLE4 TLE1 TLE5 TLE2 TLE3 | Repression of WNT target genes |
| REAC:R-HSA-195253 | 1.35394941889e-07 | 0.555555555556 | TLE4 TLE1 TLE5 TLE2 TLE3 | Degradation of beta-catenin by the destruction complex |
| KEGG:04330 | 6.44465221034e-07 | 0.444444444444 | TLE4 TLE1 TLE2 TLE3 | Notch signaling pathway |
| REAC:R-HSA-3769402 | 9.17480125108e-07 | 0.444444444444 | TLE4 TLE1 TLE2 TLE3 | Deactivation of the beta-catenin transactivating complex |
| REAC:R-HSA-201722 | 2.08422022609e-05 | 0.444444444444 | TLE4 TLE1 TLE2 TLE3 | Formation of the beta-catenin:TCF transactivating complex |
| CORUM:3124 | 2.73623797451e-05 | 0.222222222222 | TLE1 TLE2 | TLE1-TLE2 complex |
| GO:0090090 | 5.4694944351e-05 | 0.555555555556 | TLE4 TLE1 TLE5 TLE2 TLE3 | negative regulation of canonical Wnt signaling pathway |
| GO:0045892 | 6.2290670353e-05 | 0.888888888889 | EN1 RIPPLY3 TLE4 TLE5 TLE1 RIPPLY2 RIPPLY1 TLE2 | negative regulation of DNA-templated transcription |
| KEGG:04310 | 6.52476976687e-05 | 0.444444444444 | TLE4 TLE1 TLE2 TLE3 | Wnt signaling pathway |
| GO:1902679 | 6.82717834034e-05 | 0.888888888889 | EN1 RIPPLY3 TLE4 TLE5 TLE1 RIPPLY2 RIPPLY1 TLE2 | negative regulation of RNA biosynthetic process |
| REAC:R-HSA-195721 | 9.36026916004e-05 | 0.555555555556 | TLE4 TLE1 TLE5 TLE2 TLE3 | Signaling by WNT |
| GO:0051253 | 0.000148997932498 | 0.888888888889 | EN1 RIPPLY3 TLE4 TLE5 TLE1 RIPPLY2 RIPPLY1 TLE2 | negative regulation of RNA metabolic process |
| GO:0030178 | 0.000169798547704 | 0.555555555556 | TLE4 TLE1 TLE5 TLE2 TLE3 | negative regulation of Wnt signaling pathway |
| GO:0045934 | 0.000331600992306 | 0.888888888889 | EN1 RIPPLY3 TLE4 TLE5 TLE1 RIPPLY2 RIPPLY1 TLE2 | negative regulation of nucleobase-containing compound metabolic process |
| REAC:R-HSA-2122947 | 0.000373779293679 | 0.333333333333 | TLE4 TLE2 TLE1 | NOTCH1 Intracellular Domain Regulates Transcription |
| GO:0003714 | 0.000870425537234 | 0.555555555556 | TLE4 TLE1 TLE5 TLE2 TLE3 | transcription corepressor activity |
| GO:0009892 | 0.000922592098016 | 1.0 | EN1 RIPPLY3 TLE3 TLE5 TLE1 RIPPLY2 TLE4 RIPPLY1 TLE2 | negative regulation of metabolic process |
| GO:0060828 | 0.00108083788953 | 0.555555555556 | TLE4 TLE1 TLE5 TLE2 TLE3 | regulation of canonical Wnt signaling pathway |
| REAC:R-HSA-201681 | 0.00110410912758 | 0.444444444444 | TLE4 TLE1 TLE2 TLE3 | TCF dependent signaling in response to WNT |
| REAC:R-HSA-1980143 | 0.00122268984218 | 0.333333333333 | TLE4 TLE2 TLE1 | Signaling by NOTCH1 |
| GO:1990907 | 0.00177138039123 | 0.333333333333 | TLE4 TLE1 TLE3 | beta-catenin-TCF complex |
| GO:0060070 | 0.00326766877537 | 0.555555555556 | TLE4 TLE1 TLE5 TLE2 TLE3 | canonical Wnt signaling pathway |
| GO:0030111 | 0.00453203337276 | 0.555555555556 | TLE4 TLE1 TLE5 TLE2 TLE3 | regulation of Wnt signaling pathway |
| GO:0010558 | 0.00492757162312 | 0.888888888889 | EN1 RIPPLY3 TLE4 TLE5 TLE1 RIPPLY2 RIPPLY1 TLE2 | negative regulation of macromolecule biosynthetic process |
| GO:0031327 | 0.00588502456744 | 0.888888888889 | EN1 RIPPLY3 TLE4 TLE5 TLE1 RIPPLY2 RIPPLY1 TLE2 | negative regulation of cellular biosynthetic process |
| GO:0051172 | 0.00613253941287 | 0.888888888889 | EN1 RIPPLY3 TLE4 TLE5 TLE1 RIPPLY2 RIPPLY1 TLE2 | negative regulation of nitrogen compound metabolic process |
| GO:0009890 | 0.00616410763574 | 0.888888888889 | EN1 RIPPLY3 TLE4 TLE5 TLE1 RIPPLY2 RIPPLY1 TLE2 | negative regulation of biosynthetic process |
| GO:0016055 | 0.0158129014739 | 0.555555555556 | TLE4 TLE1 TLE5 TLE2 TLE3 | Wnt signaling pathway |
| GO:0198738 | 0.0169509750524 | 0.555555555556 | TLE4 TLE1 TLE5 TLE2 TLE3 | cell-cell signaling by wnt |
| GO:0000122 | 0.0206219094099 | 0.666666666667 | EN1 RIPPLY3 TLE4 TLE5 RIPPLY2 RIPPLY1 | negative regulation of transcription by RNA polymerase II |
| GO:0009880 | 0.0234426873659 | 0.333333333333 | RIPPLY1 RIPPLY3 RIPPLY2 | embryonic pattern specification |
| GO:0031324 | 0.0245840422709 | 0.888888888889 | EN1 RIPPLY3 TLE4 TLE5 TLE1 RIPPLY2 RIPPLY1 TLE2 | negative regulation of cellular metabolic process |
| GO:0010605 | 0.0285304622329 | 0.888888888889 | EN1 RIPPLY3 TLE4 TLE5 TLE1 RIPPLY2 RIPPLY1 TLE2 | negative regulation of macromolecule metabolic process |
| CORUM:3125 | 0.0499842271994 | 0.111111111111 | TLE1 | TLE1 homodimer complex |
| CORUM:3127 | 0.0499842271994 | 0.111111111111 | TLE1 | TLE-Histone H3 complex |
| CORUM:3120 | 0.0499842271994 | 0.111111111111 | TLE1 | OCT1-OBF1-DNA-TLE1 complex |
| CORUM:3123 | 0.0499842271994 | 0.111111111111 | TLE2 | TLE2 homodimer complex |
| CORUM:3164 | 0.0499842271994 | 0.111111111111 | TLE1 | HESX1-TLE1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TLE5 | TLE4 | 1.0 | 0.208 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| TLE4 | TLE2 | 1.0 |
mutually_exclusive (Q08117)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TLE4 | TLE1 | 1.0 | 0.262 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| TLE3 | TLE2 | 1.0 |
mutually_exclusive (Q08117)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TLE5 | TLE1 | 1.0 | 0.126 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| TLE4 | TLE3 | 1.0 | 0.088 |
mutually_exclusive (Q08117)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| TLE3 | TLE1 | 0.999 | 0.116 |
mutually_exclusive (Q08117)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| TLE2 | TLE1 | 0.999 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TLE5 | TLE2 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RIPPLY2 | TLE1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TLE4 | RIPPLY3 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TLE3 | RIPPLY2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TLE2 | RIPPLY2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TLE5 | RIPPLY2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RIPPLY1 | TLE3 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TLE5 | TLE3 | 0.996 | 0.182 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| RIPPLY3 | TLE1 | 0.99 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| RIPPLY1 | TLE1 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TLE3 | RIPPLY3 | 0.982 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| TLE2 | RIPPLY3 | 0.977 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| RIPPLY1 | TLE2 | 0.974 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TLE5 | RIPPLY3 | 0.972 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| TLE4 | RIPPLY2 | 0.97 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| RIPPLY1 | TLE4 | 0.97 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TLE3 | EN1 | 0.962 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TLE1 | EN1 | 0.953 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TLE5 | EN1 | 0.919 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TLE2 | EN1 | 0.901 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TLE5 | RIPPLY1 | 0.884 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TLE4 | EN1 | 0.864 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes