hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00047.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DR1 | Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein) | 5 | UniProt NCBI |
| CXXC1 | CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) | 5 | UniProt NCBI |
| NCOA6 | Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) | 5 | UniProt NCBI |
| ATN1 | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | 5 | UniProt NCBI |
| RERE | Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) | 5 | UniProt NCBI |
| WDR5 | WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9772755 | 1.32090489297e-07 | 0.666666666667 | CXXC1 DR1 WDR5 NCOA6 | Formation of WDR5-containing histone-modifying complexes |
| REAC:R-HSA-212165 | 4.89935586914e-05 | 0.666666666667 | CXXC1 DR1 WDR5 NCOA6 | Epigenetic regulation of gene expression |
| CORUM:2730 | 0.00025612721106 | 0.333333333333 | CXXC1 WDR5 | Set1B complex |
| CORUM:2731 | 0.00025612721106 | 0.333333333333 | CXXC1 WDR5 | Set1A complex |
| CORUM:6461 | 0.000614368794823 | 0.333333333333 | NCOA6 WDR5 | MLL3 complex |
| CORUM:6467 | 0.000614368794823 | 0.333333333333 | NCOA6 WDR5 | MLL4 complex |
| CORUM:5195 | 0.000767820823501 | 0.333333333333 | NCOA6 WDR5 | PTIP-HMT complex |
| CORUM:6469 | 0.000767820823501 | 0.333333333333 | CXXC1 WDR5 | Set1A complex |
| CORUM:6657 | 0.000767820823501 | 0.333333333333 | DR1 WDR5 | ATAC complex, GCN5-linked |
| CORUM:3075 | 0.00112572613738 | 0.333333333333 | NCOA6 WDR5 | UTX-MLL2/3 complex |
| CORUM:6470 | 0.00112572613738 | 0.333333333333 | CXXC1 WDR5 | Set1B complex |
| CORUM:6665 | 0.00155157094875 | 0.333333333333 | DR1 WDR5 | ATAC complex, YEATS2-linked |
| WP:WP5351 | 0.00407076266464 | 0.333333333333 | NCOA6 WDR5 | Kleefstra syndrome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CXXC1 | WDR5 | 1.0 | 0.464 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| DR1 | WDR5 | 0.996 | 0.07 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| ATN1 | WDR5 | 0.994 | 0.142 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RERE | WDR5 | 0.986 | 0.19 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM |
| NCOA6 | WDR5 | 0.984 | 0.352 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| ATN1 | RERE | 0.929 | 0.28 | bioplex_WMM bioplex3_WMM WMM_only |
| CXXC1 | ATN1 | 0.902 | 0.316 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CXXC1 | RERE | 0.889 | 0.322 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CXXC1 | NCOA6 | 0.469 | 0.216 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NCOA6 | ATN1 | 0.417 | 0.296 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NCOA6 | RERE | 0.357 | 0.178 | bioplex_WMM bioplex3_WMM WMM_only |
| DR1 | NCOA6 | 0.247 | 0.264 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| DR1 | ATN1 | 0.214 | 0.086 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| DR1 | RERE | 0.192 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only |
| DR1 | CXXC1 | 0.161 | 0.09 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes