hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00050.1
Complex Portal: CPX-11731
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLU7 | Pre-mRNA-splicing factor SLU7 (hSlu7) | 5 | UniProt NCBI |
| C1orf52 | UPF0690 protein C1orf52 (BCL10-associated gene protein) | 3 | UniProt NCBI |
| GCFC2 | Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9) | 5 | UniProt NCBI |
| YJU2 | Splicing factor YJU2 (Coiled-coil domain-containing protein 94) | 5 | UniProt NCBI |
| ISY1 | Pre-mRNA-splicing factor ISY1 homolog | 5 | UniProt NCBI |
| PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8) (Spliceosome-associated cyclophilin) | 5 | UniProt NCBI |
| DHX35 | Probable ATP-dependent RNA helicase DHX35 (EC 3.6.4.13) (DEAH box protein 35) | 5 | UniProt NCBI |
| CCDC12 | Coiled-coil domain-containing protein 12 | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-72163 | 8.42500920507e-09 | 0.857142857143 | CCDC12 DHX35 YJU2 SLU7 ISY1 PPWD1 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 1.03682214592e-08 | 0.857142857143 | CCDC12 DHX35 YJU2 SLU7 ISY1 PPWD1 | mRNA Splicing |
| REAC:R-HSA-72203 | 5.49269500155e-08 | 0.857142857143 | CCDC12 DHX35 YJU2 SLU7 ISY1 PPWD1 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0005681 | 7.86095307377e-07 | 0.857142857143 | CCDC12 DHX35 YJU2 SLU7 ISY1 PPWD1 | spliceosomal complex |
| CORUM:1181 | 2.57078286488e-06 | 0.571428571429 | ISY1 SLU7 DHX35 PPWD1 | C complex spliceosome |
| REAC:R-HSA-8953854 | 1.34047597764e-05 | 0.857142857143 | CCDC12 DHX35 YJU2 SLU7 ISY1 PPWD1 | Metabolism of RNA |
| KEGG:03040 | 0.00108816732534 | 0.428571428571 | ISY1 SLU7 CCDC12 | Spliceosome |
| GO:1990904 | 0.00145686134313 | 0.857142857143 | CCDC12 DHX35 YJU2 SLU7 ISY1 PPWD1 | ribonucleoprotein complex |
| GO:0071013 | 0.00202210317171 | 0.571428571429 | ISY1 SLU7 DHX35 PPWD1 | catalytic step 2 spliceosome |
| CORUM:351 | 0.00286422017167 | 0.428571428571 | ISY1 SLU7 PPWD1 | Spliceosome |
| GO:0008380 | 0.00965864313965 | 0.714285714286 | YJU2 PPWD1 SLU7 DHX35 ISY1 | RNA splicing |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DHX35 | CCDC12 | 1.0 | 0.342 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 | |
| ISY1 | CCDC12 | 0.999 | 0.458 |
structurally_consistent (Q9HCS7)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| ISY1 | DHX35 | 0.999 | 0.314 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| GCFC2 | ISY1 | 0.999 | 0.372 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| PPWD1 | CCDC12 | 0.993 | 0.298 | hein_WMM bioplex3_WMM youn_WMM hein () | |
| C1orf52 | CCDC12 | 0.99 | 0.132 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| SLU7 | CCDC12 | 0.989 | 0.27 | hein_WMM bioplex3_WMM youn_WMM WMM_only | |
| GCFC2 | CCDC12 | 0.976 | 0.316 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ISY1 | PPWD1 | 0.973 | 0.282 | hein_WMM youn_WMM WMM_only | |
| C1orf52 | YJU2 | 0.969 | 0.11 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| YJU2 | CCDC12 | 0.968 | 0.358 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| SLU7 | ISY1 | 0.959 | 0.31 | hein_WMM bioplex3_WMM youn_WMM WMM_only | |
| C1orf52 | ISY1 | 0.931 | 0.058 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PPWD1 | DHX35 | 0.879 | 0.326 | hein_WMM youn_WMM WMM_only | |
| YJU2 | ISY1 | 0.879 | 0.394 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| SLU7 | C1orf52 | 0.847 | 0.044 | hein_WMM gupta_WMM WMM_only | |
| GCFC2 | DHX35 | 0.833 | 0.156 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| YJU2 | DHX35 | 0.651 | 0.362 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| GCFC2 | YJU2 | 0.196 | 0.298 |
structurally_consistent (O75934)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| YJU2 | PPWD1 | 0.191 | 0.106 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| C1orf52 | GCFC2 | 0.161 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only | |
| C1orf52 | DHX35 | 0.12 | 0.216 | bioplex_WMM bioplex3_WMM WMM_only | |
| C1orf52 | PPWD1 | 0.089 | 0.056 | bioplex3_WMM WMM_only | |
| SLU7 | PPWD1 | 0.048 | 0.466 |
mutually_exclusive (P83876)
structurally_consistent (dimer) |
youn_WMM WMM_only |
| SLU7 | GCFC2 | 0.044 | 0.15 | youn_WMM WMM_only | |
| SLU7 | DHX35 | 0.025 | 0.2 | bioplex3_WMM youn_WMM WMM_only | |
| GCFC2 | PPWD1 | 0.016 | 0.652 | youn_WMM WMM_only | |
| SLU7 | YJU2 | 0.009 | 0.2 | youn_WMM WMM_only |
Related Complexes