hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00051.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CRMP1 | Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3) | 5 | UniProt NCBI |
| DPYSL3 | Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1) | 5 | UniProt NCBI |
| DPYSL2 | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | 5 | UniProt NCBI |
| DPYS | Dihydropyrimidinase (DHP) (DHPase) (EC 3.5.2.2) (Dihydropyrimidine amidohydrolase) (Hydantoinase) | 5 | UniProt NCBI |
| DPYSL4 | Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4) | 5 | UniProt NCBI |
| DPYSL5 | Dihydropyrimidinase-related protein 5 (DRP-5) (CRMP3-associated molecule) (CRAM) (Collapsin response mediator protein 5) (CRMP-5) (UNC33-like phosphoprotein 6) (ULIP-6) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016812 | 3.41686125941e-15 | 1.0 | DPYSL3 DPYSL2 DPYSL4 DPYSL5 DPYS CRMP1 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| REAC:R-HSA-399956 | 5.96134466021e-13 | 0.833333333333 | DPYSL3 DPYSL4 CRMP1 DPYSL5 DPYSL2 | CRMPs in Sema3A signaling |
| REAC:R-HSA-373755 | 9.91336940667e-10 | 0.833333333333 | DPYSL3 DPYSL4 CRMP1 DPYSL5 DPYSL2 | Semaphorin interactions |
| GO:0016810 | 3.89247944218e-09 | 1.0 | DPYSL3 DPYSL2 DPYSL4 DPYSL5 DPYS CRMP1 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| REAC:R-HSA-422475 | 4.10272552328e-05 | 0.833333333333 | DPYSL3 DPYSL4 CRMP1 DPYSL5 DPYSL2 | Axon guidance |
| REAC:R-HSA-9675108 | 4.92668798701e-05 | 0.833333333333 | DPYSL3 DPYSL4 CRMP1 DPYSL5 DPYSL2 | Nervous system development |
| GO:0031005 | 0.000161332517231 | 0.5 | DPYSL3 CRMP1 DPYSL4 | filamin binding |
| REAC:R-HSA-1266738 | 0.000707119981671 | 0.833333333333 | DPYSL3 DPYSL4 CRMP1 DPYSL5 DPYSL2 | Developmental Biology |
| GO:0004157 | 0.00702301080125 | 0.333333333333 | DPYS DPYSL2 | dihydropyrimidinase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DPYSL4 | DPYSL5 | 1.0 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| DPYSL2 | DPYSL5 | 1.0 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| DPYSL3 | DPYSL4 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| DPYS | DPYSL5 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DPYSL3 | DPYSL2 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM | |
| CRMP1 | DPYSL3 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| DPYSL3 | DPYSL5 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| DPYSL2 | DPYSL4 | 0.999 | 0.172 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| DPYSL3 | DPYS | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DPYSL2 | DPYS | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CRMP1 | DPYSL4 | 0.967 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| CRMP1 | DPYSL5 | 0.954 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| CRMP1 | DPYSL2 | 0.93 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| DPYS | DPYSL4 | 0.71 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CRMP1 | DPYS | 0.364 | bioplex3_WMM WMM_only |
Related Complexes