hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00059.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MFSD11 | UNC93-like protein MFSD11 (Major facilitator superfamily domain-containing protein 11) (Protein ET) | 4 | UniProt NCBI |
| XPNPEP1 | Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble) | 5 | UniProt NCBI |
| RHOC | Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9) | 5 | UniProt NCBI |
| ARHGEF11 | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | 5 | UniProt NCBI |
| RHOA | Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12) | 5 | UniProt NCBI |
| RAP1GDS1 | Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-416572 | 6.83169380613e-06 | 0.5 | RHOC RHOA ARHGEF11 | Sema4D induced cell migration and growth-cone collapse |
| REAC:R-HSA-400685 | 1.24783008572e-05 | 0.5 | RHOC RHOA ARHGEF11 | Sema4D in semaphorin signaling |
| REAC:R-HSA-373755 | 0.000227786945547 | 0.5 | RHOC RHOA ARHGEF11 | Semaphorin interactions |
| REAC:R-HSA-416482 | 0.000264877822759 | 0.5 | RHOC RHOA ARHGEF11 | G alpha (12/13) signalling events |
| REAC:R-HSA-9013106 | 0.000305777502474 | 0.5 | RHOC RHOA ARHGEF11 | RHOC GTPase cycle |
| REAC:R-HSA-5666185 | 0.000928329318648 | 0.333333333333 | RHOC RHOA | RHO GTPases Activate Rhotekin and Rhophilins |
| REAC:R-HSA-5627117 | 0.00440152140132 | 0.333333333333 | RHOC RHOA | RHO GTPases Activate ROCKs |
| REAC:R-HSA-5625900 | 0.00440152140132 | 0.333333333333 | RHOC RHOA | RHO GTPases activate CIT |
| GO:1902766 | 0.00702301080125 | 0.333333333333 | RHOC RHOA | skeletal muscle satellite cell migration |
| REAC:R-HSA-9716542 | 0.00959411672385 | 0.666666666667 | RHOC RHOA RAP1GDS1 ARHGEF11 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| KEGG:04928 | 0.0243770301627 | 0.333333333333 | ARHGEF11 RHOA | Parathyroid hormone synthesis, secretion and action |
| KEGG:04270 | 0.0325874784997 | 0.333333333333 | ARHGEF11 RHOA | Vascular smooth muscle contraction |
| WP:WP2431 | 0.039710885216 | 0.333333333333 | RHOC RHOA | Spinal cord injury |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RHOA | RAP1GDS1 | 0.991 | 0.387095238095 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| RHOC | RHOA | 0.989 | 0.838 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MFSD11 | RHOA | 0.985 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| XPNPEP1 | RHOA | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RHOC | RAP1GDS1 | 0.975 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ARHGEF11 | RHOA | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RHOC | ARHGEF11 | 0.794 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| XPNPEP1 | ARHGEF11 | 0.217 | bioplex_WMM bioplex3_WMM WMM_only | |
| XPNPEP1 | RHOC | 0.169 | bioplex_WMM bioplex3_WMM WMM_only | |
| ARHGEF11 | RAP1GDS1 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes