hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00060.1
Complex Portal: CPX-17869
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATP5PD | ATP synthase subunit d, mitochondrial (ATPase subunit d) (ATP synthase peripheral stalk subunit d) | 5 | UniProt NCBI |
| ATP5F1D | ATP synthase subunit delta, mitochondrial (ATP synthase F1 subunit delta) (F-ATPase delta subunit) | 5 | UniProt NCBI |
| ZFYVE27 | Protrudin (Spastic paraplegia 33 protein) (Zinc finger FYVE domain-containing protein 27) | 5 | UniProt NCBI |
| ATP5PB | ATP synthase F(0) complex subunit B1, mitochondrial (ATP synthase peripheral stalk-membrane subunit b) (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b) | 5 | UniProt NCBI |
| MT-ATP8 | ATP synthase protein 8 (A6L) (F-ATPase subunit 8) | 5 | UniProt NCBI |
| SLC43A3 | Equilibrative nucleobase transporter 1 (Protein FOAP-13) (Solute carrier family 43 member 3) | 5 | UniProt NCBI |
| ATP5PF | ATP synthase-coupling factor 6, mitochondrial (ATPase subunit F6) (ATP synthase peripheral stalk subunit F6) | 5 | UniProt NCBI |
| MT-ATP6 | ATP synthase subunit a (F-ATPase protein 6) | 5 | UniProt NCBI |
| ATP5IF1 | ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:563 | 4.74939571654e-10 | 0.666666666667 | ATP5PD ATP5IF1 MT-ATP8 MT-ATP6 | F1F0-ATP synthase, mitochondrial |
| WP:WP111 | 2.02452206999e-06 | 0.666666666667 | ATP5PD ATP5IF1 MT-ATP8 MT-ATP6 | Electron transport chain OXPHOS system in mitochondria |
| REAC:R-HSA-163210 | 5.75389190359e-06 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | Formation of ATP by chemiosmotic coupling |
| REAC:R-HSA-8949613 | 2.85755298292e-05 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | Cristae formation |
| KEGG:00190 | 0.000576849408541 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | Oxidative phosphorylation |
| REAC:R-HSA-1592230 | 0.000714100505716 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | Mitochondrial biogenesis |
| GO:0046933 | 0.0010743908712 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | proton-transporting ATP synthase activity, rotational mechanism |
| KEGG:05415 | 0.00191301809451 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | Diabetic cardiomyopathy |
| REAC:R-HSA-163200 | 0.00199859610367 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| GO:0015252 | 0.00254971303757 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | proton channel activity |
| GO:0045259 | 0.00254971303757 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | proton-transporting ATP synthase complex |
| GO:0005753 | 0.00254971303757 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | mitochondrial proton-transporting ATP synthase complex |
| KEGG:05208 | 0.0026117112518 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | Chemical carcinogenesis - reactive oxygen species |
| KEGG:04714 | 0.00272913719926 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | Thermogenesis |
| KEGG:05012 | 0.00425749387528 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | Parkinson disease |
| KEGG:05020 | 0.00464093791542 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | Prion disease |
| HP:0001258 | 0.00500109820736 | 0.5 | ZFYVE27 MT-ATP8 MT-ATP6 | Spastic paraplegia |
| REAC:R-HSA-1428517 | 0.00544369031347 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | The citric acid (TCA) cycle and respiratory electron transport |
| KEGG:05016 | 0.00626282376918 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | Huntington disease |
| HP:0010550 | 0.00990331418434 | 0.5 | ZFYVE27 MT-ATP8 MT-ATP6 | Paraplegia |
| KEGG:05014 | 0.0106340043214 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | Amyotrophic lateral sclerosis |
| GO:0046034 | 0.0115447654956 | 0.666666666667 | ATP5PD ATP5IF1 MT-ATP8 MT-ATP6 | ATP metabolic process |
| KEGG:05010 | 0.0122631731838 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | Alzheimer disease |
| GO:0009205 | 0.0153056641383 | 0.666666666667 | ATP5PD ATP5IF1 MT-ATP8 MT-ATP6 | purine ribonucleoside triphosphate metabolic process |
| GO:0009144 | 0.0160118650244 | 0.666666666667 | ATP5PD ATP5IF1 MT-ATP8 MT-ATP6 | purine nucleoside triphosphate metabolic process |
| WP:WP623 | 0.0170615762461 | 0.333333333333 | ATP5PD MT-ATP6 | Oxidative phosphorylation |
| GO:0009199 | 0.017497036198 | 0.666666666667 | ATP5PD ATP5IF1 MT-ATP8 MT-ATP6 | ribonucleoside triphosphate metabolic process |
| GO:0009141 | 0.0203408763605 | 0.666666666667 | ATP5PD ATP5IF1 MT-ATP8 MT-ATP6 | nucleoside triphosphate metabolic process |
| KEGG:05022 | 0.0219191039446 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | Pathways of neurodegeneration - multiple diseases |
| REAC:R-HSA-1852241 | 0.0232310173112 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | Organelle biogenesis and maintenance |
| GO:0016469 | 0.0252998897888 | 0.5 | ATP5PD MT-ATP8 MT-ATP6 | proton-transporting two-sector ATPase complex |
| HP:0010551 | 0.0333560250352 | 0.5 | ZFYVE27 MT-ATP8 MT-ATP6 | Paraplegia/paraparesis |
| HP:0003535 | 0.0349615340576 | 0.333333333333 | MT-ATP8 MT-ATP6 | 3-Methylglutaconic aciduria |
| HP:0002061 | 0.0388140472191 | 0.5 | ZFYVE27 MT-ATP8 MT-ATP6 | Lower limb spasticity |
| WP:WP4932 | 0.0451642815361 | 0.333333333333 | MT-ATP8 MT-ATP6 | 7q11 23 copy number variation syndrome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ATP5F1D | ATP5PB | 1.0 | 0.934 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| ATP5PD | ATP5PB | 1.0 | 0.93 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| ATP5PD | ATP5F1D | 1.0 | 0.926 |
structurally_consistent (P25705)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt gupta_WMM fraction boldt_WMM |
| ATP5F1D | ATP5PF | 1.0 | 0.82 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction | |
| ATP5PB | ATP5PF | 1.0 | 0.908 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| ATP5PB | MT-ATP6 | 1.0 | 0.826 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| ATP5PD | ATP5PF | 1.0 | 0.914 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ATP5PF | MT-ATP6 | 0.999 | 0.938 |
structurally_consistent (P24539)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATP5F1D | MT-ATP6 | 0.999 | 0.898 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| ZFYVE27 | ATP5PB | 0.999 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MT-ATP8 | ATP5PF | 0.998 | 0.752 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| MT-ATP8 | MT-ATP6 | 0.998 | 0.408 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| ATP5PB | MT-ATP8 | 0.998 | 0.728 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| ATP5PF | ATP5IF1 | 0.997 | 0.472 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| ZFYVE27 | ATP5PF | 0.996 | 0.134 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ATP5PD | ATP5IF1 | 0.996 | 0.728 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATP5F1D | ATP5IF1 | 0.995 | 0.424 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| ATP5PD | MT-ATP6 | 0.994 | 0.84 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
| ATP5F1D | MT-ATP8 | 0.994 | 0.676 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATP5PB | ATP5IF1 | 0.993 | 0.684 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MT-ATP6 | ATP5IF1 | 0.993 | 0.248 |
structurally_consistent (O75947)
|
bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATP5PB | SLC43A3 | 0.99 | 0.126 | hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ATP5PD | ZFYVE27 | 0.989 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MT-ATP8 | ATP5IF1 | 0.984 | 0.114 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ATP5PD | SLC43A3 | 0.981 | 0.092 | hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZFYVE27 | MT-ATP8 | 0.969 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATP5PD | MT-ATP8 | 0.961 | 0.632 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| ATP5F1D | ZFYVE27 | 0.931 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SLC43A3 | ATP5PF | 0.91 | 0.082 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZFYVE27 | ATP5IF1 | 0.895 | 0.068 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ATP5F1D | SLC43A3 | 0.828 | 0.106 | hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SLC43A3 | ATP5IF1 | 0.386 | 0.058 | bioplex3_WMM WMM_only | |
| MT-ATP8 | SLC43A3 | 0.372 | 0.04 | bioplex3_WMM WMM_only | |
| SLC43A3 | MT-ATP6 | 0.357 | 0.034 | bioplex3_WMM WMM_only | |
| ZFYVE27 | MT-ATP6 | 0.076 | 0.102 | bioplex3_WMM WMM_only | |
| ZFYVE27 | SLC43A3 | 0.042 | 0.07 | bioplex3_WMM WMM_only |
Related Complexes