hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00065.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SEC23B | Protein transport protein Sec23B (hSec23B) (SEC23-related protein B) | 5 | UniProt NCBI |
| SEC23A | Protein transport protein Sec23A (hSec23A) (SEC23-related protein A) | 5 | UniProt NCBI |
| SEC24D | Protein transport protein Sec24D (SEC24-related protein D) | 5 | UniProt NCBI |
| SEC23IP | SEC23-interacting protein (p125) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP1982 | 1.74584746167e-05 | 0.75 | SEC23B SEC24D SEC23A | Sterol regulatory element binding proteins SREBP signaling |
| GO:0030134 | 2.86394569693e-05 | 1.0 | SEC23IP SEC23B SEC24D SEC23A | COPII-coated ER to Golgi transport vesicle |
| REAC:R-HSA-204005 | 5.03512663474e-05 | 0.75 | SEC23IP SEC23A SEC24D | COPII-mediated vesicle transport |
| CORUM:7141 | 5.12488211613e-05 | 0.5 | SEC23A SEC23IP | Coat protein complex II (SAR1B, PREB, SEC23A , SEC24B, SEC23IP) |
| KEGG:04141 | 0.000211376960202 | 0.75 | SEC23B SEC24D SEC23A | Protein processing in endoplasmic reticulum |
| GO:0030127 | 0.000215165225046 | 0.75 | SEC23B SEC24D SEC23A | COPII vesicle coat |
| GO:0090110 | 0.000215165225046 | 0.75 | SEC23B SEC24D SEC23A | COPII-coated vesicle cargo loading |
| REAC:R-HSA-199977 | 0.000664788606793 | 0.75 | SEC23IP SEC23A SEC24D | ER to Golgi Anterograde Transport |
| GO:0070971 | 0.000998468305694 | 0.75 | SEC23B SEC24D SEC23A | endoplasmic reticulum exit site |
| REAC:R-HSA-948021 | 0.00115920951182 | 0.75 | SEC23IP SEC23A SEC24D | Transport to the Golgi and subsequent modification |
| HP:0002868 | 0.00120317586686 | 0.5 | SEC23A SEC24D | Narrow iliac wing |
| GO:0035459 | 0.00172575455775 | 0.75 | SEC23B SEC24D SEC23A | vesicle cargo loading |
| GO:0030135 | 0.00263891757684 | 1.0 | SEC23IP SEC23B SEC24D SEC23A | coated vesicle |
| GO:0090114 | 0.00350727150095 | 0.75 | SEC23B SEC24D SEC23A | COPII-coated vesicle budding |
| REAC:R-HSA-983170 | 0.00359044851421 | 0.5 | SEC23A SEC24D | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| REAC:R-HSA-5694530 | 0.00359044851421 | 0.5 | SEC23A SEC24D | Cargo concentration in the ER |
| REAC:R-HSA-446203 | 0.00516924519396 | 0.75 | SEC23IP SEC23A SEC24D | Asparagine N-linked glycosylation |
| GO:0012507 | 0.00663460918661 | 0.75 | SEC23B SEC24D SEC23A | ER to Golgi transport vesicle membrane |
| GO:0030120 | 0.0112187083505 | 0.75 | SEC23B SEC24D SEC23A | vesicle coat |
| REAC:R-HSA-1655829 | 0.012504459305 | 0.5 | SEC23A SEC24D | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| GO:0006900 | 0.0228491864842 | 0.75 | SEC23B SEC24D SEC23A | vesicle budding from membrane |
| HP:0000256 | 0.0379108682761 | 0.75 | SEC23B SEC24D SEC23A | Macrocephaly |
| HP:0011867 | 0.0391604009626 | 0.5 | SEC23A SEC24D | Abnormal iliac wing morphology |
| GO:0048475 | 0.0405772675542 | 0.75 | SEC23B SEC24D SEC23A | coated membrane |
| GO:0030117 | 0.0405772675542 | 0.75 | SEC23B SEC24D SEC23A | membrane coat |
| HP:0040194 | 0.0407260045359 | 0.75 | SEC23B SEC24D SEC23A | Increased head circumference |
| REAC:R-HSA-199991 | 0.0424877030349 | 0.75 | SEC23IP SEC23A SEC24D | Membrane Trafficking |
| CORUM:7139 | 0.049938562206 | 0.25 | SEC23A | SEC23-SEC24 adaptor complex |
| REAC:R-HSA-5653656 | 0.0499402458571 | 0.75 | SEC23IP SEC23A SEC24D | Vesicle-mediated transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SEC23B | SEC23A | 1.0 | 0.106 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction |
| SEC23A | SEC23IP | 0.995 | 0.254 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only |
| SEC23B | SEC24D | 0.993 | 0.208 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction |
| SEC23B | SEC23IP | 0.99 | 0.092 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| SEC23A | SEC24D | 0.981 | 0.302631578947 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo fraction |
| SEC24D | SEC23IP | 0.106 | 0.146 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes