hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00082.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF4E1B | Eukaryotic translation initiation factor 4E type 1B | 2 | UniProt NCBI |
| EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | 5 | UniProt NCBI |
| EIF4E | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:01521 | 3.38635083845e-06 | 1.0 | EIF4E1B EIF4EBP1 EIF4E | EGFR tyrosine kinase inhibitor resistance |
| KEGG:04211 | 4.45704451339e-06 | 1.0 | EIF4E1B EIF4EBP1 EIF4E | Longevity regulating pathway |
| KEGG:04066 | 8.19365887109e-06 | 1.0 | EIF4E1B EIF4EBP1 EIF4E | HIF-1 signaling pathway |
| KEGG:04910 | 1.7003844223e-05 | 1.0 | EIF4E1B EIF4EBP1 EIF4E | Insulin signaling pathway |
| KEGG:04150 | 2.7655198514e-05 | 1.0 | EIF4E1B EIF4EBP1 EIF4E | mTOR signaling pathway |
| WP:WP516 | 0.000173183276299 | 0.666666666667 | EIF4EBP1 EIF4E | Hypertrophy model |
| WP:WP3932 | 0.000194681531196 | 1.0 | EIF4E1B EIF4EBP1 EIF4E | Focal adhesion PI3K Akt mTOR signaling pathway |
| KEGG:04151 | 0.000201545964825 | 1.0 | EIF4E1B EIF4EBP1 EIF4E | PI3K-Akt signaling pathway |
| WP:WP3879 | 0.000237669979309 | 0.666666666667 | EIF4EBP1 EIF4E | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| WP:WP4172 | 0.000254288281733 | 1.0 | EIF4E1B EIF4EBP1 EIF4E | PI3K Akt signaling pathway |
| WP:WP4566 | 0.000927197171072 | 0.666666666667 | EIF4EBP1 EIF4E | Translation inhibitors in chronically activated PDGFRA cells |
| WP:WP107 | 0.00132925024934 | 0.666666666667 | EIF4EBP1 EIF4E | Translation factors |
| WP:WP585 | 0.00144101964081 | 0.666666666667 | EIF4EBP1 EIF4E | Interferon type I signaling pathways |
| REAC:R-HSA-166208 | 0.00188000535098 | 0.666666666667 | EIF4EBP1 EIF4E | mTORC1-mediated signalling |
| WP:WP2034 | 0.00257262049766 | 0.666666666667 | EIF4EBP1 EIF4E | Leptin signaling pathway |
| WP:WP4674 | 0.00272708951202 | 0.666666666667 | EIF4EBP1 EIF4E | Head and neck squamous cell carcinoma |
| WP:WP4806 | 0.00347772346958 | 0.666666666667 | EIF4EBP1 EIF4E | EGFR tyrosine kinase inhibitor resistance |
| WP:WP2263 | 0.00503624172141 | 0.666666666667 | EIF4E1B EIF4EBP1 | Androgen receptor network in prostate cancer |
| REAC:R-HSA-165159 | 0.005581186855 | 0.666666666667 | EIF4EBP1 EIF4E | MTOR signalling |
| WP:WP3915 | 0.00725872233472 | 0.666666666667 | EIF4EBP1 EIF4E | Angiopoietin like protein 8 regulatory pathway |
| WP:WP2380 | 0.00845205977617 | 0.666666666667 | EIF4EBP1 EIF4E | Brain derived neurotrophic factor BDNF signaling pathway |
| WP:WP481 | 0.011426766529 | 0.666666666667 | EIF4EBP1 EIF4E | Insulin signaling |
| REAC:R-HSA-72662 | 0.0120367347963 | 0.666666666667 | EIF4EBP1 EIF4E | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| WP:WP5115 | 0.0163374881119 | 0.666666666667 | EIF4EBP1 EIF4E | Network map of SARS CoV 2 signaling pathway |
| GO:0045182 | 0.0207446272651 | 1.0 | EIF4E1B EIF4EBP1 EIF4E | translation regulator activity |
| REAC:R-HSA-72613 | 0.0468187221283 | 0.666666666667 | EIF4EBP1 EIF4E | Eukaryotic Translation Initiation |
| REAC:R-HSA-72737 | 0.0468187221283 | 0.666666666667 | EIF4EBP1 EIF4E | Cap-dependent Translation Initiation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EIF4EBP1 | EIF4E | 0.998 | 0.1384 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| EIF4E1B | EIF4E | 0.982 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF4E1B | EIF4EBP1 | 0.977 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes