hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00096.1
Complex Portal: CPX-12669
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GSTA2 | Glutathione S-transferase A2 (EC 2.5.1.18) (GST HA subunit 2) (GST class-alpha member 2) (GST-gamma) (GSTA2-2) (GTH2) | 5 | UniProt NCBI |
| GSTA1 | Glutathione S-transferase A1 (EC 2.5.1.18) (13-hydroperoxyoctadecadienoate peroxidase) (EC 1.11.1.-) (Androst-5-ene-3,17-dione isomerase) (EC 5.3.3.-) (GST HA subunit 1) (GST class-alpha member 1) (GST-epsilon) (GSTA1-1) (GTH1) [Cleaved into: Glutathione S-transferase A1, N-terminally processed] | 5 | UniProt NCBI |
| GSTA5 | Glutathione S-transferase A5 (EC 2.5.1.18) (GST class-alpha member 5) (Glutathione S-transferase A5-5) | 4 | UniProt NCBI |
| GIN1 | Gypsy retrotransposon integrase-like protein 1 (GIN-1) (Ty3/Gypsy integrase 1) (Zinc finger H2C2 domain-containing protein) | 3 | UniProt NCBI |
| GSTA3 | Glutathione S-transferase A3 (EC 2.5.1.18) (GST class-alpha member 3) (Glutathione S-transferase A3-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-156590 | 1.53368765668e-08 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | Glutathione conjugation |
| KEGG:00480 | 2.9342409742e-08 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | Glutathione metabolism |
| KEGG:05204 | 3.73025454511e-08 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | Chemical carcinogenesis - DNA adducts |
| KEGG:00982 | 4.0284537322e-08 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | Drug metabolism - cytochrome P450 |
| KEGG:00980 | 5.79587326968e-08 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | Metabolism of xenobiotics by cytochrome P450 |
| KEGG:00983 | 9.75657108053e-08 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | Drug metabolism - other enzymes |
| KEGG:01524 | 1.16692891233e-07 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | Platinum drug resistance |
| REAC:R-HSA-156580 | 6.72765558294e-07 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | Phase II - Conjugation of compounds |
| KEGG:05418 | 9.41102608963e-07 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | Fluid shear stress and atherosclerosis |
| GO:0004364 | 9.61435992643e-07 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | glutathione transferase activity |
| WP:WP2884 | 1.02045626229e-06 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | NRF2 pathway |
| WP:WP702 | 2.17143997935e-06 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | Metapathway biotransformation Phase I and II |
| KEGG:05225 | 3.24685425808e-06 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | Hepatocellular carcinoma |
| KEGG:05207 | 3.58869764368e-06 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | Chemical carcinogenesis - receptor activation |
| GO:0006749 | 6.09135077526e-06 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | glutathione metabolic process |
| KEGG:05208 | 8.50711599813e-06 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | Chemical carcinogenesis - reactive oxygen species |
| REAC:R-HSA-211859 | 1.2001164198e-05 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | Biological oxidations |
| WP:WP2882 | 2.63245664316e-05 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | Nuclear receptors meta pathway |
| GO:0016765 | 3.84216218146e-05 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| KEGG:05200 | 0.000202734552549 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | Pathways in cancer |
| GO:0006805 | 0.00029151492518 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | xenobiotic metabolic process |
| GO:0071466 | 0.000727710984203 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | cellular response to xenobiotic stimulus |
| WP:WP100 | 0.000798299856649 | 0.4 | GSTA5 GSTA1 | Glutathione metabolism |
| GO:0006575 | 0.000969335687232 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | cellular modified amino acid metabolic process |
| WP:WP5066 | 0.00100346979189 | 0.4 | GSTA2 GSTA1 | FOXA2 pathway |
| REAC:R-HSA-9818027 | 0.0018206657072 | 0.4 | GSTA1 GSTA3 | NFE2L2 regulating anti-oxidant/detoxification enzymes |
| GO:0009410 | 0.00206012733421 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | response to xenobiotic stimulus |
| REAC:R-HSA-9748787 | 0.00259338296865 | 0.4 | GSTA2 GSTA1 | Azathioprine ADME |
| HPA:0400201 | 0.00285652607666 | 0.6 | GSTA3 GSTA2 GSTA1 | rectum; endothelial cells[>=Low] |
| HPA:0151293 | 0.00465166915766 | 0.6 | GSTA3 GSTA2 GSTA1 | duodenum; endocrine cells[High] |
| HPA:0151302 | 0.0130253489728 | 0.6 | GSTA3 GSTA2 GSTA1 | duodenum; enterocytes[>=Medium] |
| KEGG:01100 | 0.0139298332568 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | Metabolic pathways |
| HPA:0151292 | 0.0149049151547 | 0.6 | GSTA3 GSTA2 GSTA1 | duodenum; endocrine cells[>=Medium] |
| GO:0006790 | 0.0180995584082 | 0.8 | GSTA5 GSTA3 GSTA2 GSTA1 | sulfur compound metabolic process |
| HPA:0151291 | 0.0187750565941 | 0.6 | GSTA3 GSTA2 GSTA1 | duodenum; endocrine cells[>=Low] |
| HPA:0151301 | 0.0240343220231 | 0.6 | GSTA3 GSTA2 GSTA1 | duodenum; enterocytes[>=Low] |
| HPA:0401331 | 0.0241927281198 | 0.6 | GSTA3 GSTA2 GSTA1 | rectum; mucosal lymphoid cells[>=Low] |
| HPA:0481301 | 0.0268210610628 | 0.6 | GSTA3 GSTA2 GSTA1 | small intestine; enterocytes[>=Low] |
| REAC:R-HSA-9759194 | 0.0451765626421 | 0.4 | GSTA1 GSTA3 | Nuclear events mediated by NFE2L2 |
| REAC:R-HSA-9748784 | 0.0487218825663 | 0.4 | GSTA2 GSTA1 | Drug ADME |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GSTA1 | GSTA3 | 0.999 |
mutually_exclusive (P09210)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GSTA2 | GSTA5 | 0.996 |
mutually_exclusive (P08263)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GSTA2 | GSTA3 | 0.994 |
mutually_exclusive (P08263)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GSTA2 | GSTA1 | 0.98 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GSTA2 | GIN1 | 0.952 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| GSTA1 | GSTA5 | 0.951 |
mutually_exclusive (P09210)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| GSTA5 | GSTA3 | 0.582 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| GSTA2 | huMAP3_00096.1 huMAP3_10880.1 huMAP3_13591.1 |
| GSTA1 | huMAP3_00096.1 huMAP3_10880.1 huMAP3_13591.1 |
| GSTA5 | huMAP3_00096.1 huMAP3_10880.1 huMAP3_11246.1 huMAP3_13591.1 |
| GIN1 | huMAP3_00096.1 huMAP3_10880.1 |
| GSTA3 | huMAP3_00096.1 huMAP3_10880.1 huMAP3_13591.1 |