List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_00102.1

Confidence: Extremely High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
P4HA2	Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2)	5	UniProt   NCBI
CPSF4	Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog)	5	UniProt   NCBI
CPSF3	Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73)	5	UniProt   NCBI
CSTF1	Cleavage stimulation factor subunit 1 (CF-1 50 kDa subunit) (Cleavage stimulation factor 50 kDa subunit) (CSTF 50 kDa subunit) (CstF-50)	4	UniProt   NCBI
CPSF2	Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit)	5	UniProt   NCBI
FIP1L1	Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia)	5	UniProt   NCBI
P4HB	Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)	5	UniProt   NCBI
P4HA1	Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)	5	UniProt   NCBI
CPSF1	Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)	5	UniProt   NCBI
WDR33	pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa)	5	UniProt   NCBI
CSTF3	Cleavage stimulation factor subunit 3 (CF-1 77 kDa subunit) (Cleavage stimulation factor 77 kDa subunit) (CSTF 77 kDa subunit) (CstF-77)	5	UniProt   NCBI
CSTF2	Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-77595	1.57199867569e-23	0.818181818182	CPSF1 CPSF2 CPSF3 CSTF1 CSTF2 CSTF3 WDR33 CPSF4 FIP1L1	Processing of Intronless Pre-mRNAs
REAC:R-HSA-75067	7.9677153369e-22	0.818181818182	CPSF1 CPSF2 CPSF3 CSTF1 CSTF2 CSTF3 WDR33 CPSF4 FIP1L1	Processing of Capped Intronless Pre-mRNA
GO:0005849	9.65112024291e-21	0.818181818182	CPSF1 CPSF2 CPSF3 CSTF1 CSTF2 CSTF3 WDR33 CPSF4 FIP1L1	mRNA cleavage factor complex
REAC:R-HSA-72187	1.07721275432e-18	0.818181818182	CPSF1 CPSF2 CPSF3 CSTF1 CSTF2 CSTF3 WDR33 CPSF4 FIP1L1	mRNA 3'-end processing
REAC:R-HSA-73856	4.00571344183e-18	0.818181818182	CPSF1 CPSF2 CPSF3 CSTF1 CSTF2 CSTF3 WDR33 CPSF4 FIP1L1	RNA Polymerase II Transcription Termination
CORUM:1147	1.58771661311e-17	0.545454545455	CPSF3 CPSF2 CPSF1 CSTF1 CSTF2 CSTF3	Polyadenylation complex (CSTF1, CSTF2, CSTF3, SYMPK CPSF1, CPSF2, CPSF3)
KEGG:03015	2.60072830919e-17	0.818181818182	CPSF1 CPSF2 CPSF3 CSTF1 CSTF2 CSTF3 WDR33 CPSF4 FIP1L1	mRNA surveillance pathway
CORUM:1144	5.52460635237e-15	0.454545454545	CPSF4 FIP1L1 CPSF2 CPSF1 CPSF3	Cleavage and polyadenylation factor (CPSF)
GO:0005847	1.1344382768e-14	0.636363636364	CPSF1 CPSF2 CPSF3 WDR33 CSTF2 CPSF4 FIP1L1	mRNA cleavage and polyadenylation specificity factor complex
REAC:R-HSA-72203	3.46299368775e-12	0.818181818182	CPSF1 CPSF2 CPSF3 CSTF1 CSTF2 CSTF3 WDR33 CPSF4 FIP1L1	Processing of Capped Intron-Containing Pre-mRNA
REAC:R-HSA-159231	2.42089135812e-11	0.545454545455	CPSF1 CPSF2 CPSF3 WDR33 CPSF4 FIP1L1	Transport of Mature mRNA Derived from an Intronless Transcript
REAC:R-HSA-159234	2.86021265449e-11	0.545454545455	CPSF1 CPSF2 CPSF3 WDR33 CPSF4 FIP1L1	Transport of Mature mRNAs Derived from Intronless Transcripts
WP:WP411	7.95377465448e-11	0.636363636364	CPSF1 CPSF2 CPSF3 CSTF1 CSTF2 CSTF3 CPSF4	mRNA processing
REAC:R-HSA-72202	2.40827758888e-09	0.545454545455	CPSF1 CPSF2 CPSF3 WDR33 CPSF4 FIP1L1	Transport of Mature Transcript to Cytoplasm
REAC:R-HSA-8953854	1.3406503364e-08	0.818181818182	CPSF1 CPSF2 CPSF3 CSTF1 CSTF2 CSTF3 WDR33 CPSF4 FIP1L1	Metabolism of RNA
CORUM:1146	2.10621603952e-08	0.272727272727	CSTF1 CSTF3 CSTF2	Cleavage stimulation factor
CORUM:2211	2.10448665621e-07	0.272727272727	CSTF1 CSTF3 CSTF2	BARD1-BRCA1-CSTF complex
REAC:R-HSA-73857	1.32080020605e-06	0.818181818182	CPSF1 CPSF2 CPSF3 CSTF1 CSTF2 CSTF3 WDR33 CPSF4 FIP1L1	RNA Polymerase II Transcription
GO:0031124	3.49422884807e-06	0.454545454545	CSTF3 CPSF3 WDR33 CPSF2 CPSF1	mRNA 3'-end processing
REAC:R-HSA-74160	4.02013372746e-06	0.818181818182	CPSF1 CPSF2 CPSF3 CSTF1 CSTF2 CSTF3 WDR33 CPSF4 FIP1L1	Gene expression (Transcription)
HPA:0301361	9.9925725501e-06	0.727272727273	P4HA2 CPSF2 WDR33 CSTF2 P4HB CSTF1 FIP1L1 CSTF3	lung; alveolar cells type I[>=Low]
GO:0003723	3.17467927449e-05	0.909090909091	CPSF3 CPSF2 CPSF1 CSTF1 CSTF2 P4HB WDR33 CPSF4 FIP1L1 CSTF3	RNA binding
GO:0006378	6.30804475724e-05	0.363636363636	CPSF3 WDR33 CPSF2 CPSF1	mRNA polyadenylation
GO:0031123	0.000124995723993	0.454545454545	CSTF3 CPSF3 WDR33 CPSF2 CPSF1	RNA 3'-end processing
GO:0140513	0.000188828148492	0.818181818182	CPSF1 CPSF2 CPSF3 CSTF1 CSTF2 CSTF3 WDR33 CPSF4 FIP1L1	nuclear protein-containing complex
GO:0180012	0.000316805542726	0.272727272727	CPSF3 CSTF3 CPSF1	co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway
HPA:0301362	0.00164380197181	0.545454545455	P4HA2 CPSF2 CSTF1 CSTF2 CSTF3 P4HB	lung; alveolar cells type I[>=Medium]
REAC:R-HSA-6784531	0.00211028007235	0.272727272727	CPSF4 CSTF2 CPSF1	tRNA processing in the nucleus
HPA:0570792	0.00480730276593	0.636363636364	P4HA2 CPSF2 WDR33 CSTF2 CSTF3 CSTF1 FIP1L1	testis; round or early spermatids[>=Medium]
HPA:0570762	0.00624914422221	0.636363636364	P4HA2 CPSF2 WDR33 CSTF2 CSTF3 CSTF1 FIP1L1	testis; pachytene spermatocytes[>=Medium]
REAC:R-HSA-72306	0.0123901602043	0.272727272727	CPSF4 CSTF2 CPSF1	tRNA processing
HPA:0570791	0.0178476756014	0.636363636364	P4HA2 CPSF2 WDR33 CSTF2 CSTF3 CSTF1 FIP1L1	testis; round or early spermatids[>=Low]
HPA:0570782	0.018212843076	0.545454545455	P4HA2 CPSF2 CSTF1 CSTF2 CSTF3 FIP1L1	testis; preleptotene spermatocytes[>=Medium]
HPA:0570813	0.0184576858089	0.545454545455	P4HA2 CPSF2 WDR33 CSTF2 CSTF1 FIP1L1	testis; spermatogonia cells[High]
WP:WP4786	0.0247024437992	0.181818181818	P4HA2 P4HB	Type I collagen synthesis in the context of osteogenesis imperfecta
HPA:0570761	0.025476572755	0.636363636364	P4HA2 CPSF2 WDR33 CSTF2 CSTF3 CSTF1 FIP1L1	testis; pachytene spermatocytes[>=Low]
GO:0005848	0.0257510396046	0.181818181818	CSTF1 CSTF3	mRNA cleavage stimulating factor complex
GO:0003676	0.0259523693915	0.909090909091	CPSF3 CPSF2 CPSF1 CSTF1 CSTF2 P4HB WDR33 CPSF4 FIP1L1 CSTF3	nucleic acid binding
HPA:0570793	0.0290598498087	0.454545454545	CSTF1 CSTF3 CSTF2 CPSF2 FIP1L1	testis; round or early spermatids[High]
HPA:0301371	0.0372251422124	0.545454545455	P4HA2 CPSF2 CSTF1 CSTF3 FIP1L1 P4HB	lung; alveolar cells type II[>=Low]
HPA:0570812	0.0447286981173	0.636363636364	P4HA2 CPSF2 WDR33 CSTF2 CSTF3 CSTF1 FIP1L1	testis; spermatogonia cells[>=Medium]
CORUM:472	0.049976851631	0.0909090909091	P4HB	Prolyl 4-hydroxylase (alpha(I)-type)



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?
CPSF1	WDR33	1.0	0.574
CPSF4	WDR33	1.0	0.428
CPSF3	CPSF2	1.0	0.814
CPSF4	CPSF1	1.0	0.568
CPSF4	FIP1L1	1.0	0.71
CPSF2	CPSF1	1.0	0.728
CPSF2	FIP1L1	1.0	0.67
CPSF4	CPSF2	1.0	0.714
CPSF3	WDR33	1.0	0.23
P4HB	P4HA1	1.0	0.246
CPSF2	WDR33	1.0	0.53
FIP1L1	CPSF1	1.0	0.606
CPSF4	CPSF3	0.999	0.736
CPSF3	CPSF1	0.999	0.644
CSTF1	CSTF3	0.999	0.828
P4HA2	P4HA1	0.999	0.134
P4HA2	WDR33	0.999	0.062
FIP1L1	WDR33	0.999	0.78
CSTF3	CSTF2	0.998	0.652
CPSF1	CSTF3	0.996	0.528
P4HA2	P4HB	0.996	0.321
CPSF4	P4HA1	0.995	0.076
P4HA2	CPSF2	0.995	0.024
FIP1L1	CSTF3	0.994	0.518
FIP1L1	P4HB	0.993	0.076
CSTF1	FIP1L1	0.992	0.682
CSTF1	CSTF2	0.992	0.546
P4HA2	FIP1L1	0.991	0.042
CPSF2	P4HB	0.991	0.112
P4HA2	CPSF4	0.991	0.03
CPSF2	CSTF3	0.991	0.544
P4HB	WDR33	0.99	0.028
CPSF3	FIP1L1	0.99	0.556
WDR33	CSTF3	0.99	0.416
P4HA2	CPSF1	0.989	0.078
CPSF3	P4HA1	0.988	0.19
CSTF1	P4HA1	0.988	0.128
FIP1L1	P4HA1	0.985	0.136
CPSF4	P4HB	0.983	0.034
CSTF1	P4HB	0.981	0.048
P4HA1	WDR33	0.98	0.086
CSTF1	CPSF2	0.98	0.548
CPSF3	CSTF1	0.98	0.502
FIP1L1	CSTF2	0.978	0.662
CPSF3	CSTF3	0.978	0.572
P4HA1	CSTF3	0.978	0.348925925926
CPSF3	P4HB	0.977	0.12
CPSF2	P4HA1	0.977	0.182235690236
P4HA1	CPSF1	0.977	0.376972222222
CPSF3	CSTF2	0.976	0.484
CPSF4	CSTF3	0.973	0.642
CPSF4	CSTF2	0.966	0.484
P4HB	CSTF3	0.962	0.112
CPSF4	CSTF1	0.961	0.738
CSTF1	WDR33	0.96	0.364
CSTF1	CPSF1	0.955	0.326
P4HA2	CSTF1	0.939	0.05
P4HA2	CSTF3	0.936	0.14
P4HA2	CPSF3	0.934	0.096
WDR33	CSTF2	0.913	0.39
CPSF2	CSTF2	0.912	0.658
P4HB	CSTF2	0.834	0.07
CPSF1	CSTF2	0.815	0.438
P4HA2	CSTF2	0.796	0.086
P4HB	CPSF1	0.795	0.124
P4HA1	CSTF2	0.73	0.28





Related Complexes

Genename	Complexes
P4HA2	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1
CPSF4	huMAP3_00102.1 huMAP3_09096.1 huMAP3_09559.1 huMAP3_10074.1 huMAP3_11757.1 huMAP3_15022.1
CPSF3	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1 huMAP3_14094.1
CSTF1	huMAP3_00102.1 huMAP3_03810.1 huMAP3_06559.1 huMAP3_07938.1 huMAP3_09096.1 huMAP3_09191.1 huMAP3_10656.1 huMAP3_11757.1 huMAP3_14584.1
CPSF2	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1 huMAP3_15022.1
FIP1L1	huMAP3_00102.1 huMAP3_08087.1 huMAP3_08486.1 huMAP3_09096.1 huMAP3_09490.1 huMAP3_09587.1 huMAP3_11073.1 huMAP3_11757.1
P4HB	huMAP3_00102.1 huMAP3_04071.1 huMAP3_09096.1 huMAP3_11757.1 huMAP3_12074.1
P4HA1	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1
CPSF1	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1
WDR33	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1 huMAP3_15022.1
CSTF3	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1
CSTF2	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1