hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00107.1
Complex Portal: CPX-19838
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SUSD4 | Sushi domain-containing protein 4 | 5 | UniProt NCBI |
| CBR4 | 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) (3-ketoacyl-[acyl-carrier-protein] reductase beta subunit) (KAR beta subunit) (Carbonyl reductase family member 4) (CBR4) (Quinone reductase CBR4) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 45C member 1) | 5 | UniProt NCBI |
| MOCOS | Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (hMCS) (EC 2.8.1.9) (Molybdenum cofactor sulfurtransferase) | 5 | UniProt NCBI |
| HSD17B8 | (3R)-3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (HSD17B8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (Estradiol 17-beta-dehydrogenase 8) (EC 1.1.1.62) (Protein Ke6) (Ke6) (Short chain dehydrogenase/reductase family 30C member 1) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239) | 5 | UniProt NCBI |
| CYP24A1 | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.15.16) (Cytochrome P450 24A1) (Cytochrome P450-CC24) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00061 | 0.000476443303259 | 0.4 | CBR4 HSD17B8 | Fatty acid biosynthesis |
| KEGG:01212 | 0.00553191318989 | 0.4 | CBR4 HSD17B8 | Fatty acid metabolism |
| REAC:R-HSA-75105 | 0.00704059925156 | 0.4 | CBR4 HSD17B8 | Fatty acyl-CoA biosynthesis |
| KEGG:01100 | 0.0139298332568 | 0.8 | CBR4 MOCOS CYP24A1 HSD17B8 | Metabolic pathways |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CBR4 | HSD17B8 | 1.0 | 0.902 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MOCOS | HSD17B8 | 0.998 | 0.03 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SUSD4 | HSD17B8 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| HSD17B8 | CYP24A1 | 0.958 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CBR4 | CYP24A1 | 0.865 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CBR4 | MOCOS | 0.611 | 0.158 | bioplex_WMM bioplex3_WMM WMM_only | |
| SUSD4 | CBR4 | 0.451 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MOCOS | CYP24A1 | 0.041 | bioplex3_WMM WMM_only |
Related Complexes