hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00115.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TLK1 | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | 5 | UniProt NCBI |
| CDIN1 | CDAN1-interacting nuclease 1 (Protein HH114) | 5 | UniProt NCBI |
| CABIN1 | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | 5 | UniProt NCBI |
| UBN2 | Ubinuclein-2 | 3 | UniProt NCBI |
| IPO4 | Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4) | 5 | UniProt NCBI |
| ASF1A | Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA) | 5 | UniProt NCBI |
| HIRA | Protein HIRA (TUP1-like enhancer of split protein 1) | 5 | UniProt NCBI |
| CDAN1 | Codanin-1 | 5 | UniProt NCBI |
| ASF1B | Histone chaperone ASF1B (Anti-silencing function protein 1 homolog B) (hAsf1) (hAsf1b) (CCG1-interacting factor A-II) (CIA-II) (hCIA-II) | 5 | UniProt NCBI |
| TONSL | Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2) | 5 | UniProt NCBI |
| UBN1 | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1150 | 4.03136208942e-10 | 0.363636363636 | ASF1A ASF1B IPO4 HIRA | Histone H3.3 complex |
| CORUM:6149 | 2.10621603952e-08 | 0.272727272727 | ASF1A IPO4 CDAN1 | Codanin-1-Asf1-histone H3.1-histone H4-importin-4 complex, cytosolic |
| REAC:R-HSA-2559584 | 6.11535741268e-08 | 0.363636363636 | ASF1A UBN1 CABIN1 HIRA | Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
| CORUM:7382 | 8.42140472852e-08 | 0.272727272727 | HIRA CABIN1 UBN1 | Prohibitin-HIRA complex |
| CORUM:7383 | 8.42140472852e-08 | 0.272727272727 | HIRA CABIN1 UBN1 | OGT-HIRA complex |
| CORUM:2235 | 2.10448665621e-07 | 0.272727272727 | ASF1A ASF1B HIRA | ASF1-interacting protein complex |
| CORUM:1149 | 1.17706123706e-06 | 0.272727272727 | ASF1A IPO4 ASF1B | Histone H3.1 complex |
| REAC:R-HSA-2559586 | 3.3660441591e-05 | 0.363636363636 | ASF1A UBN1 CABIN1 HIRA | DNA Damage/Telomere Stress Induced Senescence |
| GO:0006334 | 0.000103844617735 | 0.454545454545 | ASF1A UBN1 ASF1B CABIN1 HIRA | nucleosome assembly |
| GO:0034728 | 0.000273639968177 | 0.454545454545 | ASF1A UBN1 ASF1B CABIN1 HIRA | nucleosome organization |
| GO:0006325 | 0.000401078542902 | 0.636363636364 | CDAN1 UBN1 ASF1B TLK1 HIRA ASF1A CABIN1 | chromatin organization |
| CORUM:2236 | 0.000512126948792 | 0.181818181818 | ASF1A ASF1B | ASF1-histone containing complex |
| GO:0071824 | 0.001108873533 | 0.636363636364 | CDAN1 UBN1 ASF1B TLK1 HIRA ASF1A CABIN1 | protein-DNA complex organization |
| REAC:R-HSA-2559583 | 0.00159038796724 | 0.363636363636 | ASF1A UBN1 CABIN1 HIRA | Cellular Senescence |
| GO:0065004 | 0.00366167405381 | 0.454545454545 | ASF1A UBN1 ASF1B CABIN1 HIRA | protein-DNA complex assembly |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| ASF1A | HIRA | 1.0 | 0.086 |
| HIRA | ASF1B | 1.0 | 0.054 |
| UBN2 | ASF1A | 1.0 | 0.09 |
| CABIN1 | ASF1A | 1.0 | 0.032 |
| IPO4 | ASF1A | 0.999 | 0.05 |
| IPO4 | ASF1B | 0.999 | 0.074 |
| TLK1 | ASF1B | 0.999 | 0.044 |
| TLK1 | ASF1A | 0.999 | 0.086 |
| CABIN1 | HIRA | 0.999 | 0.252 |
| ASF1A | UBN1 | 0.999 | 0.07 |
| UBN2 | HIRA | 0.998 | 0.266 |
| CABIN1 | ASF1B | 0.997 | 0.03 |
| ASF1A | CDAN1 | 0.997 | 0.114 |
| UBN2 | ASF1B | 0.997 | 0.096 |
| CABIN1 | UBN2 | 0.997 | 0.174 |
| ASF1B | UBN1 | 0.997 | 0.036 |
| CDIN1 | ASF1A | 0.994 | 0.114 |
| ASF1A | ASF1B | 0.991 | 0.136 |
| CDAN1 | ASF1B | 0.991 | 0.088 |
| ASF1B | TONSL | 0.989 | 0.15 |
| ASF1A | TONSL | 0.984 | 0.097 |
| CDIN1 | ASF1B | 0.982 | 0.044 |
| HIRA | UBN1 | 0.975 | 0.404 |
| UBN2 | UBN1 | 0.972 | 0.094 |
| TLK1 | HIRA | 0.956 | 0.124 |
| TLK1 | UBN1 | 0.894 | 0.158 |
| CABIN1 | UBN1 | 0.884 | 0.124 |
| TLK1 | UBN2 | 0.806 | 0.154 |
| TLK1 | CABIN1 | 0.806 | 0.056 |
| CDIN1 | CDAN1 | 0.802 | 0.098 |
| IPO4 | HIRA | 0.794 | 0.144 |
| TLK1 | CDAN1 | 0.772 | 0.13 |
| TLK1 | CDIN1 | 0.72 | 0.19 |
| IPO4 | TONSL | 0.656 | 0.052 |
| TLK1 | IPO4 | 0.65 | 0.016 |
| CABIN1 | CDAN1 | 0.648 | 0.068 |
| CDAN1 | UBN1 | 0.645 | 0.04 |
| CDIN1 | UBN1 | 0.634 | 0.122 |
| UBN2 | CDAN1 | 0.634 | 0.072 |
| CDIN1 | CABIN1 | 0.563 | 0.162 |
| CDIN1 | UBN2 | 0.549 | 0.092 |
| IPO4 | UBN1 | 0.496 | 0.06 |
| HIRA | CDAN1 | 0.425 | 0.082 |
| CDIN1 | HIRA | 0.37 | 0.084 |
| TONSL | UBN1 | 0.263 | 0.062 |
| CDIN1 | TONSL | 0.234 | 0.082 |
| CDAN1 | TONSL | 0.234 | 0.134 |
| HIRA | TONSL | 0.226 | 0.074 |
| IPO4 | CDAN1 | 0.194 | 0.104 |
| CDIN1 | IPO4 | 0.181 | 0.07 |
| UBN2 | TONSL | 0.18 | 0.112 |
| CABIN1 | TONSL | 0.18 | 0.038 |
| TLK1 | TONSL | 0.165 | 0.04 |
| CABIN1 | IPO4 | 0.157 | 0.052 |
| UBN2 | IPO4 | 0.116 | 0.066 |
Related Complexes