hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00123.1
Complex Portal: CPX-13886
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PHKG1 | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26) | 5 | UniProt NCBI |
| FAM171B | Protein FAM171B | 3 | UniProt NCBI |
| PHKG2 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) | 5 | UniProt NCBI |
| PHKB | Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta) | 5 | UniProt NCBI |
| PHKA1 | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) | 5 | UniProt NCBI |
| PHKA2 | Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-70221 | 3.05263965109e-10 | 0.8 | PHKB PHKA2 PHKG1 PHKA1 | Glycogen breakdown (glycogenolysis) |
| CORUM:6640 | 2.80233355908e-09 | 0.6 | PHKB PHKG1 PHKA1 | Phosphorylase kinase complex |
| REAC:R-HSA-8982491 | 4.53395842532e-09 | 0.8 | PHKB PHKA2 PHKG1 PHKA1 | Glycogen metabolism |
| WP:WP500 | 1.08962168682e-08 | 0.8 | PHKB PHKA2 PHKG1 PHKA1 | Glycogen synthesis and degradation |
| KEGG:04922 | 3.55181171997e-07 | 0.8 | PHKB PHKA2 PHKG1 PHKA1 | Glucagon signaling pathway |
| KEGG:04910 | 1.26993763053e-06 | 0.8 | PHKB PHKA2 PHKG1 PHKA1 | Insulin signaling pathway |
| HP:0009051 | 1.5789202482e-06 | 0.6 | PHKB PHKA1 PHKA2 | Increased muscle glycogen content |
| HP:0012269 | 2.89409262838e-06 | 0.6 | PHKB PHKA1 PHKA2 | Abnormal muscle glycogen content |
| GO:0005964 | 3.84440695359e-06 | 0.6 | PHKB PHKA1 PHKA2 | phosphorylase kinase complex |
| KEGG:04020 | 4.45587121914e-06 | 0.8 | PHKB PHKA2 PHKG1 PHKA1 | Calcium signaling pathway |
| HP:0002913 | 3.84190241496e-05 | 0.6 | PHKB PHKA1 PHKA2 | Myoglobinuria |
| REAC:R-HSA-71387 | 7.36330282621e-05 | 0.8 | PHKB PHKA2 PHKG1 PHKA1 | Metabolism of carbohydrates |
| HP:0034370 | 0.000198995738245 | 0.6 | PHKB PHKA1 PHKA2 | Abnormal muscle tissue metabolite concentration |
| HP:0100607 | 0.00288300984678 | 0.4 | PHKB PHKA2 | Dysmenorrhea |
| HP:0003546 | 0.00413163038045 | 0.6 | PHKB PHKA1 PHKA2 | Exercise intolerance |
| HP:0003326 | 0.0060639757194 | 0.6 | PHKB PHKA1 PHKA2 | Myalgia |
| HP:0012028 | 0.00672241921037 | 0.4 | PHKB PHKA2 | Hepatocellular adenoma |
| HP:0003162 | 0.0121560512731 | 0.4 | PHKB PHKA2 | Fasting hypoglycemia |
| GO:0004689 | 0.0140440992017 | 0.4 | PHKA1 PHKA2 | phosphorylase kinase activity |
| HP:0002149 | 0.0176485923371 | 0.4 | PHKB PHKA2 | Hyperuricemia |
| HP:0001943 | 0.0231575360078 | 0.6 | PHKB PHKA1 PHKA2 | Hypoglycemia |
| HP:0032243 | 0.0303400604109 | 0.6 | PHKB PHKA1 PHKA2 | Abnormal tissue metabolite concentration |
| HP:0000876 | 0.0337209222644 | 0.4 | PHKB PHKA2 | Oligomenorrhea |
| HP:0003236 | 0.0367035812988 | 0.6 | PHKB PHKA1 PHKA2 | Elevated circulating creatine kinase concentration |
| HP:0011015 | 0.0424786634528 | 0.6 | PHKB PHKA1 PHKA2 | Abnormal blood glucose concentration |
| HP:0001947 | 0.0425110382594 | 0.4 | PHKB PHKA2 | Renal tubular acidosis |
| HP:0040081 | 0.0429461819912 | 0.6 | PHKB PHKA1 PHKA2 | Abnormal circulating creatine kinase concentration |
| HP:0011021 | 0.044369092363 | 0.6 | PHKB PHKA1 PHKA2 | Abnormality of circulating enzyme level |
| GO:0005975 | 0.0494529381498 | 0.8 | PHKB PHKA2 PHKG1 PHKA1 | carbohydrate metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PHKG2 | PHKA2 | 1.0 | 0.25 |
mutually_exclusive (Q16816)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| PHKG2 | PHKB | 1.0 | 0.188 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 boldt_WMM | |
| PHKB | PHKA2 | 1.0 | 0.24 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PHKG2 | PHKA1 | 1.0 | 0.084 |
mutually_exclusive (Q16816)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 boldt_WMM |
| PHKG1 | PHKG2 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | |
| PHKA1 | PHKA2 | 0.997 | 0.054 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PHKG1 | PHKA2 | 0.997 |
mutually_exclusive (P15735)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PHKB | PHKA1 | 0.981 | 0.146 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM | |
| FAM171B | PHKG2 | 0.963 | bioplex3_HEK293 bioplex () bioplex3_WMM | ||
| PHKG1 | PHKB | 0.799 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PHKG1 | PHKA1 | 0.799 |
mutually_exclusive (P15735)
structurally_consistent (dimer) |
bioplex_WMM bioplex3_WMM WMM_only | |
| PHKG1 | FAM171B | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FAM171B | PHKA2 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FAM171B | PHKA1 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FAM171B | PHKB | 0.164 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes