hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00133.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TSSK6 | Testis-specific serine/threonine-protein kinase 6 (TSK-6) (TSSK-6) (Testis-specific kinase 6) (EC 2.7.11.1) (Cancer/testis antigen 72) (CT72) (Serine/threonine-protein kinase SSTK) (Small serine/threonine kinase) | 5 | UniProt NCBI |
| CDK11A | Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) | 5 | UniProt NCBI |
| FKBP5 | Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) | 5 | UniProt NCBI |
| CDC37 | Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] | 5 | UniProt NCBI |
| CDK15 | Cyclin-dependent kinase 15 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) (Cell division protein kinase 15) (Serine/threonine-protein kinase ALS2CR7) (Serine/threonine-protein kinase PFTAIRE-2) | 5 | UniProt NCBI |
| STK11 | Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19) | 5 | UniProt NCBI |
| CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | 5 | UniProt NCBI |
| A6NIL8 | None | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5285 | 7.02050133195e-08 | 0.428571428571 | FKBP5 CHUK CDC37 | TNF-alpha/NF-kappa B signaling complex 9 |
| CORUM:5269 | 0.000307617328197 | 0.285714285714 | FKBP5 CDC37 | TNF-alpha/NF-kappa B signaling complex 8 |
| CORUM:5268 | 0.000573957048441 | 0.285714285714 | FKBP5 CDC37 | TNF-alpha/NF-kappa B signaling complex 7 |
| CORUM:5286 | 0.000922010129722 | 0.285714285714 | CDC37 CHUK | TNF-alpha/NF-kappa B signaling complex 10 |
| CORUM:5266 | 0.00159705726664 | 0.285714285714 | CDC37 CHUK | TNF-alpha/NF-kappa B signaling complex 6 |
| GO:0004674 | 0.0058499573846 | 0.714285714286 | CDK15 STK11 TSSK6 CHUK CDK11A | protein serine/threonine kinase activity |
| KEGG:04151 | 0.0127794263112 | 0.428571428571 | CDC37 CHUK STK11 | PI3K-Akt signaling pathway |
| GO:1902911 | 0.0150328542879 | 0.571428571429 | STK11 TSSK6 CHUK CDK11A | protein kinase complex |
| WP:WP4172 | 0.0189167579285 | 0.428571428571 | CDC37 CHUK STK11 | PI3K Akt signaling pathway |
| KEGG:04920 | 0.0197669780141 | 0.285714285714 | STK11 CHUK | Adipocytokine signaling pathway |
| GO:0004672 | 0.0241566055694 | 0.714285714286 | CDK15 STK11 TSSK6 CHUK CDK11A | protein kinase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CDC37 | CHUK | 0.998 | 0.25 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| CDK11A | FKBP5 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 | |
| CDK11A | CDC37 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| FKBP5 | CDK15 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CDC37 | STK11 | 0.991 | 0.139 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TSSK6 | CDC37 | 0.986 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TSSK6 | FKBP5 | 0.983 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FKBP5 | CDC37 | 0.975 | 0.16 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 fraction boldt_WMM |
| FKBP5 | STK11 | 0.974 | 0.236 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| FKBP5 | CHUK | 0.958 | 0.126 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| CDC37 | CDK15 | 0.957 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| A6NIL8 | CDC37 | 0.952 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| A6NIL8 | CDK15 | 0.871 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| A6NIL8 | CHUK | 0.843 | bioplex3_WMM WMM_only | |
| A6NIL8 | STK11 | 0.703 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FKBP5 | A6NIL8 | 0.664 | bioplex_WMM bioplex3_WMM WMM_only | |
| CDK11A | CHUK | 0.512 | bioplex3_WMM WMM_only | |
| CDK11A | STK11 | 0.22 | bioplex3_WMM WMM_only | |
| STK11 | CHUK | 0.147 | 0.18 | bioplex3_WMM WMM_only |
| CDK11A | A6NIL8 | 0.13 | bioplex3_WMM WMM_only |
Related Complexes