hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_00133.1

Confidence: Extremely High

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Genename	Protein Name	Uniprot Annotation Score	Links
A6NIL8		None	UniProt NCBI
CDC37	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]	5	UniProt NCBI
CDK11A	Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2)	5	UniProt NCBI
CDK15	Cyclin-dependent kinase 15 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) (Cell division protein kinase 15) (Serine/threonine-protein kinase ALS2CR7) (Serine/threonine-protein kinase PFTAIRE-2)	5	UniProt NCBI
CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)	5	UniProt NCBI
FKBP5	Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)	5	UniProt NCBI
STK11	Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19)	5	UniProt NCBI
TSSK6	Testis-specific serine/threonine-protein kinase 6 (TSK-6) (TSSK-6) (Testis-specific kinase 6) (EC 2.7.11.1) (Cancer/testis antigen 72) (CT72) (Serine/threonine-protein kinase SSTK) (Small serine/threonine kinase)	5	UniProt NCBI

Showing 1 to 8 of 8 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:5285	7.02050133195e-08	0.428571428571	FKBP5 CHUK CDC37	TNF-alpha/NF-kappa B signaling complex 9
CORUM:5269	0.000307617328197	0.285714285714	FKBP5 CDC37	TNF-alpha/NF-kappa B signaling complex 8
CORUM:5268	0.000573957048441	0.285714285714	FKBP5 CDC37	TNF-alpha/NF-kappa B signaling complex 7
CORUM:5286	0.000922010129722	0.285714285714	CDC37 CHUK	TNF-alpha/NF-kappa B signaling complex 10
CORUM:5266	0.00159705726664	0.285714285714	CDC37 CHUK	TNF-alpha/NF-kappa B signaling complex 6
GO:0004674	0.0058499573846	0.714285714286	TSSK6 CDK15 STK11 CHUK CDK11A	protein serine/threonine kinase activity
KEGG:04151	0.0127794263112	0.428571428571	CDC37 STK11 CHUK	PI3K-Akt signaling pathway
GO:1902911	0.0150328542879	0.571428571429	TSSK6 CHUK STK11 CDK11A	protein kinase complex
WP:WP4172	0.0189167579285	0.428571428571	CDC37 STK11 CHUK	PI3K Akt signaling pathway
KEGG:04920	0.0197669780141	0.285714285714	CHUK STK11	Adipocytokine signaling pathway

Showing 1 to 10 of 11 entries

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Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
CDC37	CHUK	0.998	0.25		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
CDK11A	FKBP5	0.996			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116
CDK11A	CDC37	0.994			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM
FKBP5	CDK15	0.993			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CDC37	STK11	0.991	0.139	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSSK6	CDC37	0.986			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
TSSK6	FKBP5	0.983			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
FKBP5	CDC37	0.975	0.16		bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 fraction boldt_WMM
FKBP5	STK11	0.974	0.236		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
FKBP5	CHUK	0.958	0.126		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only

Showing 1 to 10 of 20 entries

Related Complexes

Genename	Complexes
TSSK6	huMAP3_00133.1 huMAP3_01040.1 huMAP3_07570.1 huMAP3_09784.1 huMAP3_10304.1 huMAP3_10591.1 huMAP3_13837.1 huMAP3_14256.1 huMAP3_14477.1
CDK11A	huMAP3_00133.1 huMAP3_02101.1 huMAP3_09784.1 huMAP3_10591.1 huMAP3_13837.1 huMAP3_14373.1 huMAP3_14389.1 huMAP3_14477.1
FKBP5	huMAP3_00133.1 huMAP3_09784.1 huMAP3_10591.1 huMAP3_11794.1 huMAP3_13837.1 huMAP3_14477.1
CDC37	huMAP3_00133.1 huMAP3_05923.1 huMAP3_09784.1 huMAP3_10591.1 huMAP3_13837.1 huMAP3_14477.1
CDK15	huMAP3_00133.1 huMAP3_04202.1 huMAP3_08037.1 huMAP3_09784.1 huMAP3_10591.1 huMAP3_11443.1
STK11	huMAP3_00133.1 huMAP3_01132.1 huMAP3_01890.1 huMAP3_09784.1 huMAP3_10591.1 huMAP3_13837.1 huMAP3_14477.1
CHUK	huMAP3_00133.1 huMAP3_00283.1 huMAP3_01074.1 huMAP3_09784.1 huMAP3_10591.1 huMAP3_12825.1 huMAP3_13837.1 huMAP3_14477.1
A6NIL8	huMAP3_00133.1 huMAP3_05923.1 huMAP3_09784.1 huMAP3_10591.1 huMAP3_11443.1 huMAP3_12825.1 huMAP3_13837.1 huMAP3_14477.1 huMAP3_15024.1