hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00159.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CDK12 | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | 5 | UniProt NCBI |
| CDK13 | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | 5 | UniProt NCBI |
| CCNK | Cyclin-K | 5 | UniProt NCBI |
| GTF2F2 | General transcription factor IIF subunit 2 (General transcription factor IIF 30 kDa subunit) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0008024 | 5.38272230028e-06 | 1.0 | CCNK CDK12 CDK13 | cyclin/CDK positive transcription elongation factor complex |
| GO:0008353 | 8.07408345042e-06 | 1.0 | CCNK CDK12 CDK13 | RNA polymerase II CTD heptapeptide repeat kinase activity |
| REAC:R-HSA-6796648 | 1.67930110599e-05 | 1.0 | CCNK CDK12 CDK13 | TP53 Regulates Transcription of DNA Repair Genes |
| GO:0140994 | 5.38272230028e-05 | 1.0 | CCNK CDK12 CDK13 | RNA polymerase II CTD heptapeptide repeat modifying activity |
| GO:0019908 | 6.5361627932e-05 | 1.0 | CCNK CDK12 CDK13 | nuclear cyclin-dependent protein kinase holoenzyme complex |
| GO:0032806 | 0.000109576846827 | 1.0 | CCNK CDK12 CDK13 | carboxy-terminal domain protein kinase complex |
| GO:0002945 | 0.00140460216025 | 0.666666666667 | CCNK CDK13 | cyclin K-CDK13 complex |
| GO:0002944 | 0.00140460216025 | 0.666666666667 | CCNK CDK12 | cyclin K-CDK12 complex |
| GO:0032968 | 0.00155858646605 | 1.0 | CCNK CDK12 CDK13 | positive regulation of transcription elongation by RNA polymerase II |
| GO:0008023 | 0.00155858646605 | 1.0 | CCNK CDK12 CDK13 | transcription elongation factor complex |
| GO:0000307 | 0.00252170927764 | 1.0 | CCNK CDK12 CDK13 | cyclin-dependent protein kinase holoenzyme complex |
| GO:0032786 | 0.00296587998745 | 1.0 | CCNK CDK12 CDK13 | positive regulation of DNA-templated transcription, elongation |
| REAC:R-HSA-3700989 | 0.00297633187542 | 1.0 | CCNK CDK12 CDK13 | Transcriptional Regulation by TP53 |
| GO:0034243 | 0.00731242824493 | 1.0 | CCNK CDK12 CDK13 | regulation of transcription elongation by RNA polymerase II |
| GO:0032784 | 0.0133044554856 | 1.0 | CCNK CDK12 CDK13 | regulation of DNA-templated transcription elongation |
| GO:0006368 | 0.0150763323228 | 1.0 | CCNK CDK12 CDK13 | transcription elongation by RNA polymerase II |
| GO:0006354 | 0.0243625856112 | 1.0 | CCNK CDK12 CDK13 | DNA-templated transcription elongation |
| GO:1902554 | 0.0312870733704 | 1.0 | CCNK CDK12 CDK13 | serine/threonine protein kinase complex |
| GO:1902911 | 0.0458676185213 | 1.0 | CCNK CDK12 CDK13 | protein kinase complex |
| CORUM:1083 | 0.0499402709677 | 0.333333333333 | CCNK | P-TEFb.4 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CDK12 | CCNK | 0.996 | 0.59 | hein_WMM bioplex_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction |
| CDK12 | CDK13 | 0.99 | 0.392 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| CDK13 | CCNK | 0.983 | 0.38 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| CDK12 | GTF2F2 | 0.961 | 0.102 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| CCNK | GTF2F2 | 0.067 | 0.45 | bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| CDK13 | GTF2F2 | 0.008 | 0.154 | youn_WMM WMM_only |
Related Complexes