hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00178.1
Complex Portal: CPX-10741
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| APOC3 | Apolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3) | 5 | UniProt NCBI |
| C5 | Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain] | 5 | UniProt NCBI |
| UBE2U | Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U) | 5 | UniProt NCBI |
| SAA2 | Serum amyloid A-2 protein (SAA2) [Cleaved into: Amyloid A2 protein (AA2)] | 5 | UniProt NCBI |
| RBP4 | Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP) [Cleaved into: Plasma retinol-binding protein(1-182); Plasma retinol-binding protein(1-181); Plasma retinol-binding protein(1-179); Plasma retinol-binding protein(1-176)] | 5 | UniProt NCBI |
| SERPINF2 | Alpha-2-antiplasmin (Alpha-2-AP) (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Serpin F2) | 5 | UniProt NCBI |
| SERPINA6 | Corticosteroid-binding globulin (CBG) (Serpin A6) (Transcortin) | 5 | UniProt NCBI |
| SAA4 | Serum amyloid A-4 protein (Constitutively expressed serum amyloid A protein) (C-SAA) | 4 | UniProt NCBI |
| ITIH1 | Inter-alpha-trypsin inhibitor heavy chain H1 (ITI heavy chain H1) (ITI-HC1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP1533 | 0.0203730153813 | 0.25 | SAA2 SAA4 | Vitamin B12 metabolism |
| KEGG:04610 | 0.0316509404433 | 0.25 | C5 SERPINF2 | Complement and coagulation cascades |
| WP:WP176 | 0.0350131971748 | 0.25 | SAA2 SAA4 | Folate metabolism |
| REAC:R-HSA-975634 | 0.04306231829 | 0.25 | RBP4 APOC3 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 0.0498119601581 | 0.25 | RBP4 APOC3 | Metabolism of fat-soluble vitamins |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| UBE2U | SAA4 | 0.999 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UBE2U | SERPINF2 | 0.999 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UBE2U | RBP4 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| C5 | UBE2U | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UBE2U | SERPINA6 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UBE2U | SAA2 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UBE2U | ITIH1 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| APOC3 | UBE2U | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SAA2 | SAA4 | 0.902 | bioplex3_WMM WMM_only | ||
| RBP4 | SAA4 | 0.768 | bioplex3_WMM WMM_only | ||
| SAA2 | RBP4 | 0.73 | bioplex3_WMM WMM_only | ||
| SAA2 | SERPINA6 | 0.703 | bioplex3_WMM WMM_only | ||
| APOC3 | SAA4 | 0.656 | bioplex3_WMM WMM_only | ||
| APOC3 | ITIH1 | 0.649 | 0.338 | bioplex3_WMM WMM_only | |
| SERPINF2 | SAA4 | 0.647 | bioplex3_WMM WMM_only | ||
| SERPINA6 | ITIH1 | 0.634 | 0.406 | bioplex3_WMM WMM_only | |
| C5 | SERPINA6 | 0.633 | 0.424 | bioplex3_WMM WMM_only | |
| SAA4 | ITIH1 | 0.633 | bioplex3_WMM WMM_only | ||
| SERPINA6 | SAA4 | 0.616 | bioplex3_WMM WMM_only | ||
| C5 | SAA4 | 0.616 | bioplex3_WMM WMM_only | ||
| C5 | ITIH1 | 0.534 | 0.468 | bioplex3_WMM WMM_only | |
| APOC3 | SAA2 | 0.474 | bioplex3_WMM WMM_only | ||
| C5 | SAA2 | 0.468 | bioplex3_WMM WMM_only | ||
| SAA2 | SERPINF2 | 0.427 | bioplex3_WMM WMM_only | ||
| C5 | SERPINF2 | 0.418 | 0.38 | bioplex3_WMM WMM_only | |
| SAA2 | ITIH1 | 0.418 | bioplex3_WMM WMM_only | ||
| SERPINF2 | SERPINA6 | 0.401 | 0.402 | bioplex3_WMM WMM_only | |
| RBP4 | SERPINA6 | 0.388 | 0.324 | bioplex3_WMM WMM_only | |
| SERPINF2 | ITIH1 | 0.384 | 0.384 | bioplex3_WMM WMM_only | |
| APOC3 | SERPINA6 | 0.37 | bioplex3_WMM WMM_only | ||
| RBP4 | SERPINF2 | 0.364 | 0.472 | bioplex3_WMM WMM_only | |
| C5 | RBP4 | 0.356 | 0.382 | bioplex3_WMM WMM_only | |
| RBP4 | ITIH1 | 0.356 | 0.574 | bioplex3_WMM WMM_only | |
| APOC3 | RBP4 | 0.343 | 0.22 | bioplex3_WMM WMM_only | |
| APOC3 | C5 | 0.335 | 0.404 | bioplex3_WMM WMM_only | |
| APOC3 | SERPINF2 | 0.323 | 0.37 | bioplex3_WMM WMM_only |
Related Complexes