hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00184.1
Complex Portal: CPX-22183
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RNF34 | E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34) | 5 | UniProt NCBI |
| PDE9A | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35) | 5 | UniProt NCBI |
| PALD1 | Paladin | 4 | UniProt NCBI |
| UNC119 | Protein unc-119 homolog A (Retinal protein 4) (hRG4) | 5 | UniProt NCBI |
| AVPI1 | Arginine vasopressin-induced protein 1 (AVP-induced protein 1) | 5 | UniProt NCBI |
| SPDEF | SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor) | 5 | UniProt NCBI |
| PRKG2 | cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) | 5 | UniProt NCBI |
| RSPRY1 | RING finger and SPRY domain-containing protein 1 | 4 | UniProt NCBI |
| CYS1 | Cystin-1 (Cilia-associated protein) | 4 | UniProt NCBI |
| PSKH2 | Serine/threonine-protein kinase H2 (EC 2.7.11.1) (Protein serine kinase H2) (PSK-H2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0004592 | 0.0061877325188 | 0.2 | PRKG2 RSPRY1 | Thoracic platyspondyly |
| REAC:R-HSA-418457 | 0.00669318453569 | 0.2 | PDE9A PRKG2 | cGMP effects |
| REAC:R-HSA-392154 | 0.0137668647983 | 0.2 | PDE9A PRKG2 | Nitric oxide stimulates guanylate cyclase |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PALD1 | UNC119 | 0.999 | 0.066 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| UNC119 | AVPI1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PDE9A | UNC119 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| UNC119 | PSKH2 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| UNC119 | SPDEF | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RNF34 | UNC119 | 0.996 | 0.072 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| UNC119 | CYS1 | 0.985 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UNC119 | RSPRY1 | 0.977 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| UNC119 | PRKG2 | 0.966 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | ||
| PDE9A | PALD1 | 0.918 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| PDE9A | RSPRY1 | 0.693 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| PDE9A | PRKG2 | 0.65 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| PDE9A | AVPI1 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | ||
| AVPI1 | PRKG2 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PALD1 | PRKG2 | 0.495 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| PALD1 | RSPRY1 | 0.468 | 0.036 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| RNF34 | PDE9A | 0.46 |
structurally_consistent (Q13432)
|
bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| RNF34 | PRKG2 | 0.45 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| PALD1 | AVPI1 | 0.336 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RNF34 | AVPI1 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | ||
| AVPI1 | RSPRY1 | 0.218 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RNF34 | PALD1 | 0.216 | 0.042 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| PRKG2 | RSPRY1 | 0.201 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | ||
| RNF34 | RSPRY1 | 0.051 | 0.128 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
Related Complexes