hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00185.1
Complex Portal: CPX-14351
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PEMT | Phosphatidylethanolamine N-methyltransferase (PEAMT) (PEMT) (EC 2.1.1.17) (EC 2.1.1.71) (PEMT2) (Phospholipid methyltransferase) (PLMT) | 5 | UniProt NCBI |
| SLC40A1 | Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5655799 | 0.0249718442457 | 0.5 | SLC40A1 | Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) |
| WP:WP528 | 0.0310970405539 | 0.5 | PEMT | Acetylcholine synthesis |
| REAC:R-HSA-5619060 | 0.0499419797295 | 0.5 | SLC40A1 | Defective CP causes aceruloplasminemia (ACERULOP) |
| REAC:R-HSA-5619049 | 0.0499419797295 | 0.5 | SLC40A1 | Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PEMT | SLC40A1 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes