hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00210.1
Complex Portal: CPX-18929
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PDE4DIP | Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein) | 5 | UniProt NCBI |
| PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | 5 | UniProt NCBI |
| AKAP9 | A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) | 5 | UniProt NCBI |
| PALM2AKAP2 | PALM2-AKAP2 fusion protein (A-kinase anchor protein 2) (AKAP-2) (AKAP-KL) (Paralemmin A kinase anchor protein) (Paralemmin-2) (Protein kinase A-anchoring protein 2) (PRKA2) | 5 | UniProt NCBI |
| SPA17 | Sperm surface protein Sp17 (Cancer/testis antigen 22) (CT22) (Sp17-1) (Sperm autoantigenic protein 17) (Sperm protein 17) | 5 | UniProt NCBI |
| AKAP5 | A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 79 kDa) (AKAP 79) (H21) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein) | 5 | UniProt NCBI |
| MAP2 | Microtubule-associated protein 2 (MAP-2) | 5 | UniProt NCBI |
| AKAP14 | A-kinase anchor protein 14 (AKAP-14) (A-kinase anchor protein 28 kDa) (AKAP 28) (Protein kinase A-anchoring protein 14) (PRKA14) | 5 | UniProt NCBI |
| PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0051018 | 0.0219369042126 | 0.5 | AKAP9 AKAP14 PRKAR2B | protein kinase A binding |
| WP:WP35 | 0.0298411603065 | 0.333333333333 | AKAP9 PRKAR2B | G protein signaling pathways |
| CORUM:878 | 0.0499436884912 | 0.166666666667 | PRKAR2B | PKA (RII-alpha and RII-beta)-AKAP5-ADRB1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PRKAR2A | PRKAR2B | 1.0 | 0.074 |
mutually_exclusive (P22694)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| SPA17 | AKAP14 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| AKAP14 | PRKAR2B | 0.999 |
mutually_exclusive (P22612)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PRKAR2A | AKAP14 | 0.999 |
mutually_exclusive (P22612)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PRKAR2A | AKAP9 | 0.998 | 0.16 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| PALM2AKAP2 | PRKAR2B | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| AKAP9 | PRKAR2B | 0.997 | 0.138 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| MAP2 | PRKAR2B | 0.996 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| PRKAR2A | MAP2 | 0.996 | 0.09 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PRKAR2A | AKAP5 | 0.99 | 0.078 |
mutually_exclusive (P22694)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM |
| SPA17 | PRKAR2B | 0.983 | 0.19 |
mutually_exclusive (Q9HAT0)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| AKAP5 | PRKAR2B | 0.976 | 0.134 |
mutually_exclusive (P22694)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM |
| PRKAR2A | SPA17 | 0.975 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PDE4DIP | AKAP9 | 0.974 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PDE4DIP | PRKAR2A | 0.969 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PDE4DIP | PRKAR2B | 0.968 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| AKAP9 | PALM2AKAP2 | 0.908 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PRKAR2A | PALM2AKAP2 | 0.805 | bioplex_WMM bioplex3_WMM WMM_only | ||
| AKAP9 | AKAP5 | 0.681 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only | |
| PALM2AKAP2 | AKAP5 | 0.378 | bioplex_WMM bioplex3_WMM WMM_only | ||
| AKAP5 | MAP2 | 0.197 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only | |
| PALM2AKAP2 | MAP2 | 0.195 | bioplex_WMM bioplex3_WMM WMM_only | ||
| AKAP9 | MAP2 | 0.088 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only | |
| PDE4DIP | AKAP5 | 0.042 | bioplex3_WMM WMM_only | ||
| AKAP9 | SPA17 | 0.011 | 0.106 | WMM_only bioplex_WMM |
Related Complexes