hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00222.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LMAN1 | Protein ERGIC-53 (ER-Golgi intermediate compartment 53 kDa protein) (Gp58) (Intracellular mannose-specific lectin MR60) (Lectin mannose-binding 1) | 5 | UniProt NCBI |
| MCFD2 | Multiple coagulation factor deficiency protein 2 (Neural stem cell-derived neuronal survival protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0030976 | 1.02525705128e-05 | 1.0 | MCFD2 LMAN1 | Abnormal factor VIII activity |
| HP:0003125 | 1.02525705128e-05 | 1.0 | MCFD2 LMAN1 | Reduced factor VIII activity |
| HP:0011889 | 2.05051410255e-05 | 1.0 | MCFD2 LMAN1 | Bleeding with minor or no trauma |
| HP:0003225 | 2.05051410255e-05 | 1.0 | MCFD2 LMAN1 | Reduced coagulation factor V activity |
| HP:0031899 | 3.41752350426e-05 | 1.0 | MCFD2 LMAN1 | Abnormal coagulation factor V activity |
| HP:0030137 | 0.000123030846153 | 1.0 | MCFD2 LMAN1 | Prolonged bleeding following circumcision |
| HP:0004846 | 0.000123030846153 | 1.0 | MCFD2 LMAN1 | Prolonged bleeding after surgery |
| HP:0005261 | 0.000225556551281 | 1.0 | MCFD2 LMAN1 | Joint hemorrhage |
| HP:0006298 | 0.000358839967947 | 1.0 | MCFD2 LMAN1 | Prolonged bleeding after dental extraction |
| REAC:R-HSA-5694530 | 0.000599775374997 | 1.0 | MCFD2 LMAN1 | Cargo concentration in the ER |
| HP:0000132 | 0.000717679935894 | 1.0 | MCFD2 LMAN1 | Menorrhagia |
| HP:0011890 | 0.000864633446577 | 1.0 | MCFD2 LMAN1 | Prolonged bleeding following procedure |
| HP:0002149 | 0.000943236487175 | 1.0 | MCFD2 LMAN1 | Hyperuricemia |
| HP:0003645 | 0.00148662272435 | 1.0 | MCFD2 LMAN1 | Prolonged partial thromboplastin time |
| HP:0010989 | 0.00158914842948 | 1.0 | MCFD2 LMAN1 | Abnormality of the intrinsic pathway |
| HP:0010932 | 0.00294248773717 | 1.0 | MCFD2 LMAN1 | Abnormal circulating nucleobase concentration |
| HP:0008151 | 0.00294248773717 | 1.0 | MCFD2 LMAN1 | Prolonged prothrombin time |
| REAC:R-HSA-204005 | 0.0031270340064 | 1.0 | MCFD2 LMAN1 | COPII-mediated vesicle transport |
| HP:0032199 | 0.00323297723503 | 1.0 | MCFD2 LMAN1 | Abnormal prothrombin time |
| HP:0000225 | 0.00353713682691 | 1.0 | MCFD2 LMAN1 | Gingival bleeding |
| HP:0012200 | 0.00353713682691 | 1.0 | MCFD2 LMAN1 | Abnormality of prothrombin |
| HP:0010990 | 0.00526298619656 | 1.0 | MCFD2 LMAN1 | Abnormality of the common coagulation pathway |
| HP:0000421 | 0.0102628230833 | 1.0 | MCFD2 LMAN1 | Epistaxis |
| REAC:R-HSA-199977 | 0.0173490580694 | 1.0 | MCFD2 LMAN1 | ER to Golgi Anterograde Transport |
| REAC:R-HSA-948021 | 0.0251290503268 | 1.0 | MCFD2 LMAN1 | Transport to the Golgi and subsequent modification |
| HP:0003256 | 0.0252247409849 | 1.0 | MCFD2 LMAN1 | Abnormality of the coagulation cascade |
| HP:0003077 | 0.0277776310426 | 1.0 | MCFD2 LMAN1 | Hyperlipidemia |
| HP:0002170 | 0.0291002126388 | 1.0 | MCFD2 LMAN1 | Intracranial hemorrhage |
| HP:0002239 | 0.0318376489657 | 1.0 | MCFD2 LMAN1 | Gastrointestinal hemorrhage |
| HP:0000978 | 0.0371758206793 | 1.0 | MCFD2 LMAN1 | Bruising susceptibility |
| HP:0002157 | 0.0376816141579 | 1.0 | MCFD2 LMAN1 | Azotemia |
| HP:0000790 | 0.0423875440233 | 1.0 | MCFD2 LMAN1 | Hematuria |
| HP:0012614 | 0.0423875440233 | 1.0 | MCFD2 LMAN1 | Abnormal urine cytology |
| HP:0004364 | 0.042927512737 | 1.0 | MCFD2 LMAN1 | Abnormal circulating nitrogen compound concentration |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LMAN1 | MCFD2 | 0.991 | 0.254 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
Related Complexes