hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00245.1
Complex Portal: CPX-14665
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAT2A | S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) | 5 | UniProt NCBI |
| MAT1A | S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP704 | 4.25637018258e-06 | 1.0 | MAT2A MAT1A | Methylation pathways |
| REAC:R-HSA-156581 | 6.15154230766e-05 | 1.0 | MAT2A MAT1A | Methylation |
| WP:WP3580 | 8.08710334689e-05 | 1.0 | MAT2A MAT1A | Methionine de novo and salvage pathway |
| KEGG:00270 | 0.00016825963378 | 1.0 | MAT2A MAT1A | Cysteine and methionine metabolism |
| KEGG:01230 | 0.000359441594481 | 1.0 | MAT2A MAT1A | Biosynthesis of amino acids |
| WP:WP3940 | 0.000384350227487 | 1.0 | MAT2A MAT1A | One carbon metabolism and related pathways |
| GO:0004478 | 0.000468200720083 | 1.0 | MAT2A MAT1A | methionine adenosyltransferase activity |
| WP:WP2525 | 0.000632070972113 | 1.0 | MAT2A MAT1A | Trans sulfuration one carbon metabolism and related pathways |
| GO:0048269 | 0.00140460216025 | 1.0 | MAT2A MAT1A | methionine adenosyltransferase complex |
| KEGG:01240 | 0.00144865854745 | 1.0 | MAT2A MAT1A | Biosynthesis of cofactors |
| GO:0006556 | 0.0028092043205 | 1.0 | MAT2A MAT1A | S-adenosylmethionine biosynthetic process |
| REAC:R-HSA-156580 | 0.00539968713673 | 1.0 | MAT2A MAT1A | Phase II - Conjugation of compounds |
| GO:0046500 | 0.016855225923 | 1.0 | MAT2A MAT1A | S-adenosylmethionine metabolic process |
| REAC:R-HSA-211859 | 0.0225607814134 | 1.0 | MAT2A MAT1A | Biological oxidations |
| CORUM:7197 | 0.0249718442457 | 0.5 | MAT1A | Methionine adenosyltransferase alpha1 beta-v1 |
| REAC:R-HSA-5579024 | 0.0249718442457 | 0.5 | MAT1A | Defective MAT1A causes MATD |
| CORUM:7191 | 0.0499419797295 | 0.5 | MAT2A | Methionine adenosyltransferase alpha2 beta-v1 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAT2A | MAT1A | 0.996 | 0.734 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
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