hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_00257.1

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
PLOD1	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1)	5	UniProt NCBI
COL4A6	Collagen alpha-6(IV) chain	5	UniProt NCBI
COL4A4	Collagen alpha-4(IV) chain	5	UniProt NCBI
COL14A1	Collagen alpha-1(XIV) chain (Undulin)	5	UniProt NCBI
COL4A2	Collagen alpha-2(IV) chain [Cleaved into: Canstatin]	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-1650814	7.59806873486e-11	1.0	COL4A2 COL4A4 PLOD1 COL14A1 COL4A6	Collagen biosynthesis and modifying enzymes
REAC:R-HSA-1474290	4.0904328277e-10	1.0	COL4A2 COL4A4 PLOD1 COL14A1 COL4A6	Collagen formation
REAC:R-HSA-8948216	1.16894660556e-08	0.8	COL4A2 COL4A4 COL4A6 COL14A1	Collagen chain trimerization
REAC:R-HSA-2022090	7.60097837806e-08	0.8	COL4A2 COL4A4 COL4A6 COL14A1	Assembly of collagen fibrils and other multimeric structures
REAC:R-HSA-1442490	9.02804991004e-08	0.8	COL4A2 COL4A4 COL4A6 COL14A1	Collagen degradation
KEGG:04974	1.10030772082e-07	0.8	COL4A2 COL4A4 COL4A6 COL14A1	Protein digestion and absorption
REAC:R-HSA-1474244	1.43622359195e-07	1.0	COL4A2 COL4A4 PLOD1 COL14A1 COL4A6	Extracellular matrix organization
REAC:R-HSA-2214320	8.91627220919e-07	0.6	COL4A4 COL4A6 COL4A2	Anchoring fibril formation
GO:0005581	1.16377978294e-06	0.8	COL4A2 COL4A4 COL4A6 COL14A1	collagen trimer
REAC:R-HSA-2243919	1.74530562074e-06	0.6	COL4A4 COL4A6 COL4A2	Crosslinking of collagen fibrils
REAC:R-HSA-1474228	2.03059825145e-06	0.8	COL4A2 COL4A4 COL4A6 COL14A1	Degradation of the extracellular matrix
GO:0030020	3.12047922974e-06	0.8	COL4A2 COL4A4 COL4A6 COL14A1	extracellular matrix structural constituent conferring tensile strength
REAC:R-HSA-3000157	9.10580767182e-06	0.6	COL4A4 COL4A6 COL4A2	Laminin interactions
GO:0005587	9.61003071434e-06	0.6	COL4A4 COL4A6 COL4A2	collagen type IV trimer
GO:0098651	1.92180881975e-05	0.6	COL4A4 COL4A6 COL4A2	basement membrane collagen trimer
GO:0098645	3.362820138e-05	0.6	COL4A4 COL4A6 COL4A2	collagen network
GO:0098642	3.362820138e-05	0.6	COL4A4 COL4A6 COL4A2	network-forming collagen trimer
KEGG:04512	4.44119474406e-05	0.6	COL4A4 COL4A6 COL4A2	ECM-receptor interaction
REAC:R-HSA-3000171	5.3727974474e-05	0.6	COL4A4 COL4A6 COL4A2	Non-integrin membrane-ECM interactions
KEGG:05146	9.46922201828e-05	0.6	COL4A4 COL4A6 COL4A2	Amoebiasis
KEGG:05222	9.46922201828e-05	0.6	COL4A4 COL4A6 COL4A2	Small cell lung cancer
REAC:R-HSA-3000178	9.57519237992e-05	0.6	COL4A4 COL4A6 COL4A2	ECM proteoglycans
KEGG:04933	9.80639771822e-05	0.6	COL4A4 COL4A6 COL4A2	AGE-RAGE signaling pathway in diabetic complications
REAC:R-HSA-216083	0.000123167229073	0.6	COL4A4 COL4A6 COL4A2	Integrin cell surface interactions
WP:WP4658	0.000135925027505	0.6	COL4A4 COL4A6 COL4A2	Small cell lung cancer
KEGG:04926	0.000188471529119	0.6	COL4A4 COL4A6 COL4A2	Relaxin signaling pathway
HP:0011501	0.000192384920571	0.4	COL4A4 COL4A6	Anterior lenticonus
GO:0098644	0.000349481973524	0.6	COL4A4 COL4A6 COL4A2	complex of collagen trimers
WP:WP4239	0.00044644611726	0.6	COL4A4 COL4A6 COL4A2	Epithelial to mesenchymal transition in colorectal cancer
KEGG:04510	0.0007776530092	0.6	COL4A4 COL4A6 COL4A2	Focal adhesion
GO:0005201	0.000872617123619	0.8	COL4A2 COL4A4 COL4A6 COL14A1	extracellular matrix structural constituent
WP:WP306	0.00100625954708	0.6	COL4A4 COL4A6 COL4A2	Focal adhesion
HP:0001142	0.001345957274	0.4	COL4A4 COL4A6	Lenticonus
WP:WP3932	0.00295696208302	0.6	COL4A4 COL4A6 COL4A2	Focal adhesion PI3K Akt mTOR signaling pathway
KEGG:04151	0.00349664244214	0.6	COL4A4 COL4A6 COL4A2	PI3K-Akt signaling pathway
KEGG:05165	0.00379627929445	0.6	COL4A4 COL4A6 COL4A2	Human papillomavirus infection
WP:WP4172	0.00385309020299	0.6	COL4A4 COL4A6 COL4A2	PI3K Akt signaling pathway
GO:0030198	0.00458954735571	0.8	COL4A2 COL4A4 COL4A6 COL14A1	extracellular matrix organization
GO:0043062	0.00458954735571	0.8	COL4A2 COL4A4 COL4A6 COL14A1	extracellular structure organization
GO:0045229	0.00480818953079	0.8	COL4A2 COL4A4 COL4A6 COL14A1	external encapsulating structure organization
HP:0011526	0.00499516489297	0.4	COL4A4 COL4A6	Abnormality of lens shape
REAC:R-HSA-419037	0.00531742996423	0.4	COL4A4 COL4A2	NCAM1 interactions
GO:0005604	0.0094606249379	0.6	COL4A4 COL4A6 COL4A2	basement membrane
WP:WP5087	0.0098916730515	0.6	COL4A4 COL4A6 COL4A2	Pleural mesothelioma
REAC:R-HSA-375165	0.0130168285242	0.4	COL4A4 COL4A2	NCAM signaling for neurite out-growth
KEGG:05200	0.0130900202546	0.6	COL4A4 COL4A6 COL4A2	Pathways in cancer
REAC:R-HSA-186797	0.0170393864121	0.4	COL4A4 COL4A2	Signaling by PDGF
GO:0005788	0.0196468946878	0.8	COL4A2 COL4A4 COL4A6 COL14A1	endoplasmic reticulum lumen
HP:0100751	0.0207761643339	0.4	COL14A1 COL4A6	Esophageal neoplasm
HP:0012288	0.0337209222644	0.4	COL14A1 COL4A6	Neoplasm of head and neck
GO:0062023	0.043388817269	0.8	COL4A2 COL4A4 COL4A6 COL14A1	collagen-containing extracellular matrix
GO:0038063	0.0468008499735	0.4	COL4A6 COL4A2	collagen-activated tyrosine kinase receptor signaling pathway

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
COL4A4	PLOD1	0.994		bioplex3_WMM bioplex3_HCT116 WMM_only
PLOD1	COL4A6	0.988		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PLOD1	COL4A2	0.983	0.108	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM
PLOD1	COL14A1	0.951	0.14	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM
COL14A1	COL4A2	0.888	0.378	bioplex_WMM bioplex3_WMM WMM_only boldt_WMM
COL4A6	COL4A2	0.686		bioplex_WMM bioplex3_WMM WMM_only
COL4A6	COL14A1	0.36		bioplex_WMM bioplex3_WMM WMM_only
COL4A4	COL4A2	0.107		bioplex3_WMM WMM_only
COL4A4	COL14A1	0.107		bioplex3_WMM WMM_only
COL4A4	COL4A6	0.106		bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
PLOD1	huMAP3_00257.1 huMAP3_04937.1 huMAP3_06617.1 huMAP3_06876.1 huMAP3_07573.1 huMAP3_08975.1 huMAP3_09570.1 huMAP3_10144.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1
COL4A6	huMAP3_00257.1 huMAP3_01891.1 huMAP3_07373.1 huMAP3_07573.1 huMAP3_08496.1 huMAP3_09570.1 huMAP3_10144.1 huMAP3_10679.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_13457.1 huMAP3_14730.1
COL4A4	huMAP3_00037.1 huMAP3_00257.1 huMAP3_02779.1 huMAP3_06014.1 huMAP3_06973.1 huMAP3_07573.1 huMAP3_08354.1 huMAP3_10095.1 huMAP3_10144.1 huMAP3_10555.1 huMAP3_10699.1 huMAP3_13038.1 huMAP3_14646.1 huMAP3_15166.1
COL14A1	huMAP3_00257.1 huMAP3_06218.1 huMAP3_07573.1 huMAP3_09608.1 huMAP3_10144.1 huMAP3_10984.1 huMAP3_11663.1 huMAP3_13038.1
COL4A2	huMAP3_00257.1 huMAP3_00858.1 huMAP3_02991.1 huMAP3_04937.1 huMAP3_05924.1 huMAP3_06555.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10144.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_12884.1 huMAP3_13038.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_00257.1