hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00297.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DYNC2I2 | Cytoplasmic dynein 2 intermediate chain 2 (Dynein 2 intermediate chain 2) (WD repeat-containing protein 34) | 5 | UniProt NCBI |
| DYNC2I1 | Cytoplasmic dynein 2 intermediate chain 1 (Dynein 2 intermediate chain 1) (WD repeat-containing protein 60) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0006644 | 5.12628525639e-05 | 1.0 | DYNC2I2 DYNC2I1 | Thoracic dysplasia |
| HP:0008716 | 5.12628525639e-05 | 1.0 | DYNC2I2 DYNC2I1 | Urethrovaginal fistula |
| HP:0010564 | 7.17679935894e-05 | 1.0 | DYNC2I2 DYNC2I1 | Bifid epiglottis |
| HP:0010480 | 7.17679935894e-05 | 1.0 | DYNC2I2 DYNC2I1 | Urethral fistula |
| CORUM:6236 | 0.000112778275641 | 1.0 | DYNC2I2 DYNC2I1 | Dynein-2 complex, cytoplasmic |
| WP:WP4532 | 0.000149398593408 | 1.0 | DYNC2I2 DYNC2I1 | Intraflagellar transport proteins binding to dynein |
| HP:0005716 | 0.000153788557692 | 1.0 | DYNC2I2 DYNC2I1 | Lethal skeletal dysplasia |
| HP:0003762 | 0.000153788557692 | 1.0 | DYNC2I2 DYNC2I1 | Uterus didelphys |
| HP:0002006 | 0.000266566833332 | 1.0 | DYNC2I2 DYNC2I1 | Tessier cleft |
| HP:0004599 | 0.000266566833332 | 1.0 | DYNC2I2 DYNC2I1 | Absent or minimally ossified vertebral bodies |
| HP:0000895 | 0.000310994638887 | 1.0 | DYNC2I2 DYNC2I1 | Lateral clavicle hook |
| HP:0009106 | 0.000410102820511 | 1.0 | DYNC2I2 DYNC2I1 | Abnormal pelvis bone ossification |
| HP:0100569 | 0.000584396519228 | 1.0 | DYNC2I2 DYNC2I1 | Abnormally ossified vertebrae |
| WP:WP4906 | 0.000679316681139 | 1.0 | DYNC2I2 DYNC2I1 | 3q29 copy number variation syndrome |
| HP:0005483 | 0.000789447929484 | 1.0 | DYNC2I2 DYNC2I1 | Abnormal epiglottis morphology |
| HP:0010297 | 0.000943236487175 | 1.0 | DYNC2I2 DYNC2I1 | Bifid tongue |
| HP:0002032 | 0.00119955074999 | 1.0 | DYNC2I2 DYNC2I1 | Esophageal atresia |
| HP:0004320 | 0.00119955074999 | 1.0 | DYNC2I2 DYNC2I1 | Vaginal fistula |
| WP:WP5234 | 0.00121306550203 | 1.0 | DYNC2I2 DYNC2I1 | Bardet Biedl syndrome |
| HP:0000090 | 0.00191723068589 | 1.0 | DYNC2I2 DYNC2I1 | Nephronophthisis |
| WP:WP4536 | 0.00202305274778 | 1.0 | DYNC2I2 DYNC2I1 | Genes related to primary cilium development based on CRISPR |
| REAC:R-HSA-5620924 | 0.00217867123396 | 1.0 | DYNC2I2 DYNC2I1 | Intraflagellar transport |
| HP:0002612 | 0.00253238491666 | 1.0 | DYNC2I2 DYNC2I1 | Congenital hepatic fibrosis |
| HP:0010306 | 0.00266566833332 | 1.0 | DYNC2I2 DYNC2I1 | Short thorax |
| HP:0100589 | 0.00338334826922 | 1.0 | DYNC2I2 DYNC2I1 | Urogenital fistula |
| HP:0001177 | 0.00470934738887 | 1.0 | DYNC2I2 DYNC2I1 | Preaxial hand polydactyly |
| HP:0100957 | 0.00489047613459 | 1.0 | DYNC2I2 DYNC2I1 | Abnormal renal medulla morphology |
| WP:WP4803 | 0.00514595155073 | 1.0 | DYNC2I2 DYNC2I1 | Ciliopathies |
| HP:0000773 | 0.00526298619656 | 1.0 | DYNC2I2 DYNC2I1 | Short ribs |
| HP:0001830 | 0.00667442340382 | 1.0 | DYNC2I2 DYNC2I1 | Postaxial foot polydactyly |
| HP:0001539 | 0.00733058791663 | 1.0 | DYNC2I2 DYNC2I1 | Omphalocele |
| HP:0010579 | 0.00825331926278 | 1.0 | DYNC2I2 DYNC2I1 | Cone-shaped epiphysis |
| HP:0100258 | 0.009230730985 | 1.0 | DYNC2I2 DYNC2I1 | Preaxial polydactyly |
| WP:WP4352 | 0.00925164622885 | 1.0 | DYNC2I2 DYNC2I1 | Ciliary landscape |
| HP:0004397 | 0.0102628230833 | 1.0 | DYNC2I2 DYNC2I1 | Ectopic anus |
| HP:0002589 | 0.0105293899166 | 1.0 | DYNC2I2 DYNC2I1 | Gastrointestinal atresia |
| HP:0002983 | 0.0107993742735 | 1.0 | DYNC2I2 DYNC2I1 | Micromelia |
| HP:0001162 | 0.0110727761538 | 1.0 | DYNC2I2 DYNC2I1 | Postaxial hand polydactyly |
| HP:0010322 | 0.0110727761538 | 1.0 | DYNC2I2 DYNC2I1 | Abnormal fifth toe morphology |
| HP:0000112 | 0.0113495955576 | 1.0 | DYNC2I2 DYNC2I1 | Nephropathy |
| GO:0045503 | 0.0131096201623 | 1.0 | DYNC2I2 DYNC2I1 | dynein light chain binding |
| HP:0004279 | 0.0146201655512 | 1.0 | DYNC2I2 DYNC2I1 | Short palm |
| HP:0000889 | 0.0146201655512 | 1.0 | DYNC2I2 DYNC2I1 | Abnormal clavicle morphology |
| HP:0008873 | 0.0146201655512 | 1.0 | DYNC2I2 DYNC2I1 | Disproportionate short-limb short stature |
| HP:0000062 | 0.0176036635704 | 1.0 | DYNC2I2 DYNC2I1 | Ambiguous genitalia |
| HP:0000142 | 0.0186596783332 | 1.0 | DYNC2I2 DYNC2I1 | Abnormal vagina morphology |
| HP:0006712 | 0.0197464508076 | 1.0 | DYNC2I2 DYNC2I1 | Aplasia/Hypoplasia of the ribs |
| HP:0000445 | 0.0201155433461 | 1.0 | DYNC2I2 DYNC2I1 | Wide nose |
| HP:0000774 | 0.0201155433461 | 1.0 | DYNC2I2 DYNC2I1 | Narrow chest |
| HP:0001789 | 0.0201155433461 | 1.0 | DYNC2I2 DYNC2I1 | Hydrops fetalis |
| HP:0003498 | 0.0220122688909 | 1.0 | DYNC2I2 DYNC2I1 | Disproportionate short stature |
| HP:0003336 | 0.0224018665704 | 1.0 | DYNC2I2 DYNC2I1 | Abnormal enchondral ossification |
| HP:0002089 | 0.0224018665704 | 1.0 | DYNC2I2 DYNC2I1 | Pulmonary hypoplasia |
| HP:0003270 | 0.0227948817734 | 1.0 | DYNC2I2 DYNC2I1 | Abdominal distention |
| HP:0001829 | 0.0231913144999 | 1.0 | DYNC2I2 DYNC2I1 | Foot polydactyly |
| HPA:0320853 | 0.02350632407 | 1.0 | DYNC2I2 DYNC2I1 | nasopharynx; ciliated cells (cell body)[High] |
| HP:0009136 | 0.0248112206409 | 1.0 | DYNC2I2 DYNC2I1 | Duplication involving bones of the feet |
| HP:0001773 | 0.0252247409849 | 1.0 | DYNC2I2 DYNC2I1 | Short foot |
| HP:0001305 | 0.026485807158 | 1.0 | DYNC2I2 DYNC2I1 | Dandy-Walker malformation |
| HP:0001395 | 0.026912997596 | 1.0 | DYNC2I2 DYNC2I1 | Hepatic fibrosis |
| HP:0002023 | 0.026912997596 | 1.0 | DYNC2I2 DYNC2I1 | Anal atresia |
| HP:0100259 | 0.026912997596 | 1.0 | DYNC2I2 DYNC2I1 | Postaxial polydactyly |
| HP:0005257 | 0.0282150740512 | 1.0 | DYNC2I2 DYNC2I1 | Thoracic hypoplasia |
| HP:0000089 | 0.0291002126388 | 1.0 | DYNC2I2 DYNC2I1 | Renal hypoplasia |
| HP:0031105 | 0.0299990213204 | 1.0 | DYNC2I2 DYNC2I1 | Abnormal uterus morphology |
| REAC:R-HSA-5617833 | 0.0303578612883 | 1.0 | DYNC2I2 DYNC2I1 | Cilium Assembly |
| HP:0006703 | 0.0304535519464 | 1.0 | DYNC2I2 DYNC2I1 | Aplasia/Hypoplasia of the lungs |
| HP:0025423 | 0.0304535519464 | 1.0 | DYNC2I2 DYNC2I1 | Abnormal larynx morphology |
| HP:0000204 | 0.033730956987 | 1.0 | DYNC2I2 DYNC2I1 | Cleft upper lip |
| HP:0010950 | 0.0351868219998 | 1.0 | DYNC2I2 DYNC2I1 | Abnormal fourth ventricle morphology |
| HP:0002198 | 0.0351868219998 | 1.0 | DYNC2I2 DYNC2I1 | Dilated fourth ventricle |
| GO:0035721 | 0.0365196561665 | 1.0 | DYNC2I2 DYNC2I1 | intraciliary retrograde transport |
| HP:0002350 | 0.0376816141579 | 1.0 | DYNC2I2 DYNC2I1 | Cerebellar cyst |
| HP:0001161 | 0.0418509928331 | 1.0 | DYNC2I2 DYNC2I1 | Hand polydactyly |
| HP:0002652 | 0.0423875440233 | 1.0 | DYNC2I2 DYNC2I1 | Skeletal dysplasia |
| HP:0006711 | 0.042927512737 | 1.0 | DYNC2I2 DYNC2I1 | Aplasia/Hypoplasia involving bones of the thorax |
| HP:0005445 | 0.0490927251387 | 1.0 | DYNC2I2 DYNC2I1 | Enlarged posterior fossa |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DYNC2I2 | DYNC2I1 | 1.0 | 0.23 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only |
Related Complexes