hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_00300.1

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
ATG14	Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L)	5	UniProt NCBI
BECN1	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]	5	UniProt NCBI
UVRAG	UV radiation resistance-associated gene protein (p63)	5	UniProt NCBI
NRBF2	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR)	5	UniProt NCBI
RUBCN	Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron)	5	UniProt NCBI
PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34)	5	UniProt NCBI
PIK3R4	Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)	5	UniProt NCBI
RUBCNL	Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0035032	7.24703702028e-16	0.75	PIK3C3 UVRAG NRBF2 BECN1 PIK3R4 ATG14	phosphatidylinositol 3-kinase complex, class III
GO:0097352	1.21457706821e-12	0.875	PIK3C3 UVRAG RUBCNL ATG14 BECN1 PIK3R4 RUBCN	autophagosome maturation
CORUM:6472	3.36110250117e-12	0.5	PIK3R4 BECN1 UVRAG PIK3C3	Bcl-2-Beclin1-UVRAG-PI(3)KC3 complex
KEGG:04140	5.41324653843e-12	0.875	PIK3C3 UVRAG NRBF2 ATG14 BECN1 PIK3R4 RUBCN	Autophagy - animal
GO:0005942	1.8296293945e-11	0.75	PIK3C3 UVRAG NRBF2 BECN1 PIK3R4 ATG14	phosphatidylinositol 3-kinase complex
WP:WP4923	9.0077549193e-11	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	Autophagy
GO:0036092	1.26961271201e-10	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	phosphatidylinositol-3-phosphate biosynthetic process
REAC:R-HSA-9679504	2.58251237522e-09	0.5	PIK3R4 BECN1 UVRAG PIK3C3	Translation of Replicase and Assembly of the Replication Transcription Complex
REAC:R-HSA-9694676	3.87291987229e-09	0.5	PIK3R4 BECN1 UVRAG PIK3C3	Translation of Replicase and Assembly of the Replication Transcription Complex
GO:0032984	2.77259010149e-08	0.875	PIK3C3 UVRAG RUBCNL ATG14 BECN1 PIK3R4 RUBCN	protein-containing complex disassembly
GO:0061919	3.60175570138e-08	1.0	PIK3C3 UVRAG RUBCNL NRBF2 ATG14 BECN1 PIK3R4 RUBCN	process utilizing autophagic mechanism
GO:0006914	3.60175570138e-08	1.0	PIK3C3 UVRAG RUBCNL NRBF2 ATG14 BECN1 PIK3R4 RUBCN	autophagy
KEGG:05017	1.14702950486e-07	0.625	PIK3C3 BECN1 PIK3R4 ATG14 NRBF2	Spinocerebellar ataxia
REAC:R-HSA-983170	1.36861882354e-07	0.5	PIK3R4 BECN1 ATG14 PIK3C3	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
GO:0016236	2.8945427131e-07	0.875	PIK3C3 UVRAG RUBCNL ATG14 BECN1 PIK3R4 RUBCN	macroautophagy
WP:WP4577	3.04756518364e-07	0.5	PIK3R4 BECN1 ATG14 PIK3C3	Neurodegeneration with brain iron accumulation NBIA subtypes pathway
REAC:R-HSA-9772572	3.18690821415e-07	0.5	PIK3R4 BECN1 UVRAG PIK3C3	Early SARS-CoV-2 Infection Events
REAC:R-HSA-1632852	5.13261243917e-07	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	Macroautophagy
GO:0016241	7.32096273696e-07	0.75	PIK3C3 UVRAG ATG14 BECN1 PIK3R4 RUBCN	regulation of macroautophagy
GO:0046854	7.6793688751e-07	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	phosphatidylinositol phosphate biosynthetic process
REAC:R-HSA-9612973	9.06171399401e-07	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	Autophagy
GO:0019898	9.98560810415e-07	0.75	PIK3C3 UVRAG NRBF2 BECN1 PIK3R4 ATG14	extrinsic component of membrane
REAC:R-HSA-9705683	3.85680343092e-06	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	SARS-CoV-2-host interactions
WP:WP5124	4.64427187123e-06	0.625	PIK3C3 BECN1 PIK3R4 ATG14 NRBF2	Alzheimer 39 s disease
WP:WP2059	4.64427187123e-06	0.625	PIK3C3 BECN1 PIK3R4 ATG14 NRBF2	Alzheimer 39 s disease and miRNA effects
GO:0022411	4.73897875463e-06	0.875	PIK3C3 UVRAG RUBCNL ATG14 BECN1 PIK3R4 RUBCN	cellular component disassembly
GO:0034272	5.38272230028e-06	0.375	BECN1 PIK3R4 PIK3C3	phosphatidylinositol 3-kinase complex, class III, type II
GO:0034271	5.38272230028e-06	0.375	BECN1 PIK3R4 PIK3C3	phosphatidylinositol 3-kinase complex, class III, type I
KEGG:05016	5.59705573391e-06	0.625	PIK3C3 BECN1 PIK3R4 ATG14 NRBF2	Huntington disease
WP:WP4863	7.98434088212e-06	0.375	BECN1 PIK3R4 PIK3C3	Host pathogen interaction of human coronaviruses autophagy
GO:0005776	9.20314592393e-06	0.625	PIK3C3 BECN1 RUBCNL ATG14 UVRAG	autophagosome
KEGG:05014	1.36296552901e-05	0.625	PIK3C3 BECN1 PIK3R4 ATG14 NRBF2	Amyotrophic lateral sclerosis
WP:WP2509	1.50530142152e-05	0.375	BECN1 ATG14 UVRAG	Nanoparticle triggered autophagic cell death
KEGG:05010	1.73213042512e-05	0.625	PIK3C3 BECN1 PIK3R4 ATG14 NRBF2	Alzheimer disease
GO:0006622	1.94862705925e-05	0.5	PIK3R4 BECN1 ATG14 PIK3C3	protein targeting to lysosome
KEGG:04136	2.14879728377e-05	0.375	BECN1 PIK3R4 PIK3C3	Autophagy - other
CORUM:429	2.39226645298e-05	0.25	PIK3C3 PIK3R4	Phosphatidylinositol 3-kinase complex (PIK3C3, PIK3R4)
REAC:R-HSA-9694516	2.4954440538e-05	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	SARS-CoV-2 Infection
KEGG:05022	4.60126953817e-05	0.625	PIK3C3 BECN1 PIK3R4 ATG14 NRBF2	Pathways of neurodegeneration - multiple diseases
REAC:R-HSA-9705671	4.75382642053e-05	0.5	PIK3R4 BECN1 ATG14 PIK3C3	SARS-CoV-2 activates/modulates innate and adaptive immune responses
GO:0006661	5.26755683344e-05	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	phosphatidylinositol biosynthetic process
GO:0061695	5.82916173511e-05	0.75	PIK3C3 UVRAG NRBF2 BECN1 PIK3R4 ATG14	transferase complex, transferring phosphorus-containing groups
GO:0010506	8.35341870249e-05	0.75	PIK3C3 UVRAG ATG14 BECN1 PIK3R4 RUBCN	regulation of autophagy
GO:0044248	8.95450856189e-05	1.0	PIK3C3 UVRAG RUBCNL NRBF2 ATG14 BECN1 PIK3R4 RUBCN	cellular catabolic process
REAC:R-HSA-9678108	9.20763585551e-05	0.5	PIK3R4 BECN1 UVRAG PIK3C3	SARS-CoV-1 Infection
GO:0046488	0.000115849979991	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	phosphatidylinositol metabolic process
GO:0006623	0.000120770447162	0.5	PIK3R4 BECN1 ATG14 PIK3C3	protein targeting to vacuole
REAC:R-HSA-9679506	0.000122711400125	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	SARS-CoV Infections
GO:0045022	0.000134949126163	0.5	PIK3R4 BECN1 ATG14 PIK3C3	early endosome to late endosome transport
CORUM:6816	0.000143457417375	0.25	PIK3C3 ATG14	ULK1-ATG13-ATG14-PIK3C3 complex
GO:0042149	0.000167006572063	0.5	PIK3R4 BECN1 ATG14 PIK3C3	cellular response to glucose starvation
KEGG:05131	0.000187054370925	0.5	PIK3R4 BECN1 ATG14 PIK3C3	Shigellosis
GO:0098927	0.000204451735761	0.5	PIK3R4 BECN1 ATG14 PIK3C3	vesicle-mediated transport between endosomal compartments
GO:0061462	0.000419928845551	0.5	PIK3R4 BECN1 ATG14 PIK3C3	protein localization to lysosome
GO:0046474	0.00049969922276	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	glycerophospholipid biosynthetic process
GO:0072666	0.000533585351606	0.5	PIK3R4 BECN1 ATG14 PIK3C3	establishment of protein localization to vacuole
WP:WP5420	0.000600074839289	0.5	PIK3R4 BECN1 ATG14 PIK3C3	ADHD and autism ASD linked metabolic pathways and SNP
GO:0008654	0.000955808962282	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	phospholipid biosynthetic process
GO:0045017	0.00114612948323	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	glycerolipid biosynthetic process
KEGG:04371	0.00114976317669	0.375	BECN1 PIK3R4 PIK3C3	Apelin signaling pathway
GO:0032465	0.00197464201845	0.5	PIK3R4 BECN1 UVRAG PIK3C3	regulation of cytokinesis
GO:0072665	0.00220411413747	0.5	PIK3R4 BECN1 ATG14 PIK3C3	protein localization to vacuole
REAC:R-HSA-9824446	0.00267983185965	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	Viral Infection Pathways
GO:0006650	0.00277332542848	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	glycerophospholipid metabolic process
REAC:R-HSA-1660517	0.0030606580132	0.25	PIK3C3 PIK3R4	Synthesis of PIPs at the late endosome membrane
GO:0031329	0.00321808926669	0.75	PIK3C3 UVRAG ATG14 BECN1 PIK3R4 RUBCN	regulation of cellular catabolic process
GO:0009056	0.00359097824678	1.0	PIK3C3 UVRAG RUBCNL NRBF2 ATG14 BECN1 PIK3R4 RUBCN	catabolic process
KEGG:05167	0.00396473051169	0.375	BECN1 ATG14 PIK3C3	Kaposi sarcoma-associated herpesvirus infection
REAC:R-HSA-983169	0.00426510415934	0.5	PIK3R4 BECN1 ATG14 PIK3C3	Class I MHC mediated antigen processing & presentation
GO:0016192	0.00496175592273	0.875	PIK3C3 UVRAG RUBCNL ATG14 BECN1 PIK3R4 RUBCN	vesicle-mediated transport
REAC:R-HSA-1660516	0.00583667819665	0.25	PIK3C3 PIK3R4	Synthesis of PIPs at the early endosome membrane
REAC:R-HSA-1660514	0.00666866305696	0.25	PIK3C3 PIK3R4	Synthesis of PIPs at the Golgi membrane
REAC:R-HSA-5663205	0.00732097255999	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	Infectious disease
GO:0006644	0.00752558581491	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	phospholipid metabolic process
GO:0046486	0.00806313775791	0.625	PIK3C3 BECN1 PIK3R4 ATG14 UVRAG	glycerolipid metabolic process
GO:0032801	0.00824905178996	0.375	BECN1 UVRAG PIK3R4	receptor catabolic process
GO:0007041	0.00894726611169	0.5	PIK3R4 BECN1 ATG14 PIK3C3	lysosomal transport
GO:0051302	0.0100133115528	0.5	PIK3R4 BECN1 UVRAG PIK3C3	regulation of cell division
REAC:R-HSA-5668599	0.0116541924374	0.25	PIK3C3 PIK3R4	RHO GTPases Activate NADPH Oxidases
GO:0009267	0.0142611443327	0.5	PIK3R4 BECN1 ATG14 PIK3C3	cellular response to starvation
REAC:R-HSA-109704	0.0194471683576	0.25	PIK3C3 PIK3R4	PI3K Cascade
WP:WP4971	0.0203730153813	0.25	PIK3C3 PIK3R4	Phosphoinositides metabolism
GO:0007034	0.0216379442604	0.5	PIK3R4 BECN1 ATG14 PIK3C3	vacuolar transport
REAC:R-HSA-112399	0.0240813966337	0.25	PIK3C3 PIK3R4	IRS-mediated signalling
GO:0042594	0.0243940520291	0.5	PIK3R4 BECN1 ATG14 PIK3C3	response to starvation
GO:0000407	0.0265002084656	0.375	BECN1 ATG14 PIK3C3	phagophore assembly site
GO:1990234	0.0282952795416	0.75	PIK3C3 UVRAG NRBF2 BECN1 PIK3R4 ATG14	transferase complex
REAC:R-HSA-2404192	0.02920582473	0.25	PIK3C3 PIK3R4	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REAC:R-HSA-2428928	0.02920582473	0.25	PIK3C3 PIK3R4	IRS-related events triggered by IGF1R
REAC:R-HSA-2428924	0.02920582473	0.25	PIK3C3 PIK3R4	IGF1R signaling cascade
GO:0009894	0.0298391277208	0.75	PIK3C3 UVRAG ATG14 BECN1 PIK3R4 RUBCN	regulation of catabolic process
REAC:R-HSA-74751	0.0348192347107	0.25	PIK3C3 PIK3R4	Insulin receptor signalling cascade
GO:0000910	0.0445000722229	0.5	PIK3R4 BECN1 UVRAG PIK3C3	cytokinesis
GO:0031669	0.0479799994356	0.5	PIK3R4 BECN1 ATG14 PIK3C3	cellular response to nutrient levels
WP:WP5156	0.0499436884912	0.125	PIK3R4	SARS CoV 2 replication organelle formation

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
PIK3C3	PIK3R4	0.999	0.316	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM Malo fraction
BECN1	PIK3C3	0.999	0.138	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein ()
ATG14	BECN1	0.997	0.174	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
BECN1	UVRAG	0.997	0.246	hein_WMM bioplex_WMM bioplex3_WMM hein ()
PIK3C3	RUBCNL	0.997		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
BECN1	PIK3R4	0.997	0.274	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein ()
UVRAG	RUBCNL	0.997		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
RUBCN	PIK3R4	0.996	0.182	hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only
ATG14	PIK3C3	0.996	0.156	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
UVRAG	RUBCN	0.995	0.176	hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only
NRBF2	PIK3C3	0.995	0.152	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
NRBF2	PIK3R4	0.995	0.134	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
BECN1	RUBCN	0.994	0.154	hein_WMM bioplex3_HEK293 bioplex3_WMM hein ()
BECN1	RUBCNL	0.993		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
ATG14	NRBF2	0.993	0.124	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ATG14	PIK3R4	0.992	0.24	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
RUBCN	PIK3C3	0.992	0.076	hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only
BECN1	NRBF2	0.992	0.24225	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116
PIK3R4	RUBCNL	0.983		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
UVRAG	PIK3C3	0.979	0.152	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
UVRAG	PIK3R4	0.871	0.184	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
UVRAG	NRBF2	0.423	0.218	hein_WMM WMM_only
ATG14	UVRAG	0.423	0.096	hein_WMM WMM_only
ATG14	RUBCN	0.315	0.134	hein_WMM WMM_only
NRBF2	RUBCN	0.315	0.122	hein_WMM WMM_only

Related Complexes

Genename	Complexes
ATG14	huMAP3_00300.1 huMAP3_01249.1 huMAP3_10358.1 huMAP3_12120.1 huMAP3_14783.1
BECN1	huMAP3_00300.1 huMAP3_01249.1 huMAP3_11445.1 huMAP3_14783.1
UVRAG	huMAP3_00300.1 huMAP3_11445.1 huMAP3_14783.1
NRBF2	huMAP3_00300.1 huMAP3_01249.1 huMAP3_13627.1 huMAP3_14783.1
RUBCN	huMAP3_00300.1 huMAP3_01249.1 huMAP3_11445.1 huMAP3_14783.1
PIK3C3	huMAP3_00300.1 huMAP3_01249.1 huMAP3_11445.1 huMAP3_14783.1
PIK3R4	huMAP3_00300.1 huMAP3_01249.1 huMAP3_08728.1 huMAP3_14783.1
RUBCNL	huMAP3_00300.1 huMAP3_01249.1 huMAP3_11237.1 huMAP3_11445.1 huMAP3_13535.1 huMAP3_14783.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_00300.1