hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00302.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EXT1 | Exostosin-1 (EC 2.4.1.225) (Exostosin glycosyltransferase 1) (Heparan sulfate co-polymerase subunit EXT1) (Multiple exostoses protein 1) (N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase) | 5 | UniProt NCBI |
| EXTL3 | Exostosin-like 3 (EC 2.4.1.223) (EXT-related protein 1) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Hereditary multiple exostoses gene isolog) (Multiple exostosis-like protein 3) (Putative tumor suppressor protein EXTL3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00534 | 3.41396358394e-05 | 1.0 | EXT1 EXTL3 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
| WP:WP4784 | 6.51224637934e-05 | 1.0 | EXT1 EXTL3 | Proteoglycan biosynthesis |
| WP:WP5395 | 0.000299222823835 | 1.0 | EXT1 EXTL3 | Glycosaminoglycan synthesis in fibroblasts |
| HP:0002176 | 0.00169509165811 | 1.0 | EXT1 EXTL3 | Spinal cord compression |
| HP:0010574 | 0.0077851185427 | 1.0 | EXT1 EXTL3 | Abnormality of the epiphysis of the femoral head |
| HP:0006499 | 0.00825331926278 | 1.0 | EXT1 EXTL3 | Abnormal femoral epiphysis morphology |
| HP:0001191 | 0.009230730985 | 1.0 | EXT1 EXTL3 | Abnormal carpal morphology |
| HP:0006500 | 0.00948362772432 | 1.0 | EXT1 EXTL3 | Abnormal lower limb epiphysis morphology |
| HP:0003368 | 0.00999967377346 | 1.0 | EXT1 EXTL3 | Abnormal femoral head morphology |
| HP:0002673 | 0.0119134869358 | 1.0 | EXT1 EXTL3 | Coxa valga |
| HP:0010049 | 0.0162434892157 | 1.0 | EXT1 EXTL3 | Short metacarpal |
| HP:0006505 | 0.0197464508076 | 1.0 | EXT1 EXTL3 | Abnormal limb epiphysis morphology |
| HP:0005914 | 0.020488053408 | 1.0 | EXT1 EXTL3 | Aplasia/Hypoplasia involving the metacarpal bones |
| HP:0003019 | 0.0295479082178 | 1.0 | EXT1 EXTL3 | Abnormality of the wrist |
| HP:0003367 | 0.0313728657691 | 1.0 | EXT1 EXTL3 | Abnormal femoral neck morphology |
| HP:0003366 | 0.0490927251387 | 1.0 | EXT1 EXTL3 | Abnormal femoral neck/head morphology |
| CORUM:6881 | 0.0499419797295 | 0.5 | EXT1 | EXT1-EXT2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EXT1 | EXTL3 | 0.957 | 0.138 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| EXT1 | huMAP3_00302.1 huMAP3_01808.1 huMAP3_02214.1 huMAP3_02346.1 huMAP3_02724.1 huMAP3_07980.1 huMAP3_09366.1 huMAP3_11087.1 huMAP3_11156.1 |
| EXTL3 | huMAP3_00302.1 huMAP3_10314.1 |