hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00309.1
Complex Portal: CPX-20388
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZNF830 | Zinc finger protein 830 (Coiled-coil domain-containing protein 16) | 5 | UniProt NCBI |
| PPIE | Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E) | 5 | UniProt NCBI |
| AQR | RNA helicase aquarius (EC 3.6.4.13) (Intron-binding protein of 160 kDa) (IBP160) | 5 | UniProt NCBI |
| PPIL1 | Peptidyl-prolyl cis-trans isomerase-like 1 (PPIase) (EC 5.2.1.8) (Rotamase PPIL1) | 5 | UniProt NCBI |
| CWF19L1 | CWF19-like protein 1 (C19L1) | 4 | UniProt NCBI |
| KIAA1143 | Uncharacterized protein KIAA1143 | 2 | UniProt NCBI |
| SNW1 | SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) | 5 | UniProt NCBI |
| USB1 | U6 snRNA phosphodiesterase 1 (hUsb1) (3'-5' RNA exonuclease USB1) (EC 4.6.1.-) (Mutated in poikiloderma with neutropenia protein 1) (Mutated in PN protein 1) (hMpn1) | 5 | UniProt NCBI |
| BUD31 | Protein BUD31 homolog (Protein EDG-2) (Protein G10 homolog) | 5 | UniProt NCBI |
| CDC40 | Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17) | 5 | UniProt NCBI |
| ESS2 | Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:351 | 1.15754403071e-10 | 0.636363636364 | PPIE CDC40 BUD31 SNW1 AQR PPIL1 ESS2 | Spliceosome |
| CORUM:1181 | 5.26815289345e-10 | 0.545454545455 | PPIE CDC40 SNW1 AQR PPIL1 ESS2 | C complex spliceosome |
| GO:0071007 | 1.00730083005e-09 | 0.545454545455 | PPIE CDC40 BUD31 SNW1 AQR PPIL1 | U2-type catalytic step 2 spliceosome |
| GO:0005681 | 2.27495768772e-09 | 0.727272727273 | PPIE CWF19L1 BUD31 SNW1 AQR PPIL1 ESS2 CDC40 | spliceosomal complex |
| GO:0071013 | 3.35169908732e-09 | 0.636363636364 | PPIE CDC40 BUD31 SNW1 AQR PPIL1 ESS2 | catalytic step 2 spliceosome |
| REAC:R-HSA-72163 | 6.84162555235e-09 | 0.636363636364 | PPIE CDC40 PPIL1 BUD31 SNW1 AQR ZNF830 | mRNA Splicing - Major Pathway |
| KEGG:03040 | 7.88764515918e-09 | 0.545454545455 | PPIE CDC40 BUD31 SNW1 AQR PPIL1 | Spliceosome |
| REAC:R-HSA-72172 | 8.7107121983e-09 | 0.636363636364 | PPIE CDC40 PPIL1 BUD31 SNW1 AQR ZNF830 | mRNA Splicing |
| GO:0008380 | 9.25065028919e-09 | 0.818181818182 | PPIE CWF19L1 USB1 BUD31 SNW1 AQR PPIL1 ESS2 CDC40 | RNA splicing |
| REAC:R-HSA-72203 | 6.04870606313e-08 | 0.636363636364 | PPIE CDC40 PPIL1 BUD31 SNW1 AQR ZNF830 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0006396 | 7.85449100503e-08 | 0.909090909091 | PPIE CWF19L1 PPIL1 USB1 BUD31 SNW1 AQR ZNF830 ESS2 CDC40 | RNA processing |
| GO:0000377 | 8.53459038959e-08 | 0.727272727273 | PPIE CWF19L1 BUD31 SNW1 AQR PPIL1 ESS2 CDC40 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 8.53459038959e-08 | 0.727272727273 | PPIE CWF19L1 BUD31 SNW1 AQR PPIL1 ESS2 CDC40 | mRNA splicing, via spliceosome |
| GO:0000375 | 9.6251552605e-08 | 0.727272727273 | PPIE CWF19L1 BUD31 SNW1 AQR PPIL1 ESS2 CDC40 | RNA splicing, via transesterification reactions |
| GO:0006397 | 5.45127700563e-07 | 0.727272727273 | PPIE CWF19L1 BUD31 SNW1 AQR PPIL1 ESS2 CDC40 | mRNA processing |
| GO:0005684 | 9.68844065862e-07 | 0.545454545455 | PPIE CDC40 BUD31 SNW1 AQR PPIL1 | U2-type spliceosomal complex |
| GO:0016071 | 3.02632363506e-05 | 0.727272727273 | PPIE CWF19L1 BUD31 SNW1 AQR PPIL1 ESS2 CDC40 | mRNA metabolic process |
| REAC:R-HSA-8953854 | 3.46043041626e-05 | 0.636363636364 | PPIE CDC40 PPIL1 BUD31 SNW1 AQR ZNF830 | Metabolism of RNA |
| GO:1990904 | 5.1252476381e-05 | 0.727272727273 | PPIE CWF19L1 BUD31 SNW1 AQR PPIL1 ESS2 CDC40 | ribonucleoprotein complex |
| REAC:R-HSA-6781823 | 0.0017798652926 | 0.272727272727 | ZNF830 AQR PPIE | Formation of TC-NER Pre-Incision Complex |
| REAC:R-HSA-6782210 | 0.00318376318131 | 0.272727272727 | ZNF830 AQR PPIE | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 0.00333896784021 | 0.272727272727 | ZNF830 AQR PPIE | Dual incision in TC-NER |
| REAC:R-HSA-6781827 | 0.00583099404767 | 0.272727272727 | ZNF830 AQR PPIE | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| GO:0140513 | 0.00704522774331 | 0.727272727273 | PPIE CWF19L1 BUD31 SNW1 AQR PPIL1 ESS2 CDC40 | nuclear protein-containing complex |
| REAC:R-HSA-5696398 | 0.0160674755621 | 0.272727272727 | ZNF830 AQR PPIE | Nucleotide Excision Repair |
| HP:0410252 | 0.0171180788587 | 0.181818181818 | PPIL1 CDC40 | Chronic neutropenia |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| PPIE | AQR | 1.0 | 0.414 | |
| PPIL1 | SNW1 | 1.0 | 0.356 | |
| SNW1 | CDC40 | 1.0 | 0.714 | |
| AQR | CDC40 | 1.0 | 0.608 | |
| ZNF830 | PPIE | 0.999 | 0.372 | |
| ESS2 | PPIE | 0.999 | 0.1 | |
| BUD31 | CDC40 | 0.999 | 0.446 |
structurally_consistent (dimer)
|
| AQR | SNW1 | 0.999 | 0.718 |
structurally_consistent (dimer)
|
| PPIE | CDC40 | 0.999 | 0.238 | |
| ESS2 | AQR | 0.999 | 0.162 | |
| SNW1 | BUD31 | 0.999 | 0.5 | |
| AQR | BUD31 | 0.999 | 0.342 |
structurally_consistent (Q96DI7)
|
| PPIL1 | CDC40 | 0.999 | 0.44 | |
| PPIE | PPIL1 | 0.998 | 0.376 | |
| ESS2 | SNW1 | 0.998 | 0.186 | |
| ESS2 | CDC40 | 0.998 | 0.092 | |
| PPIE | BUD31 | 0.997 | 0.194 | |
| PPIE | SNW1 | 0.996 | 0.416 | |
| CWF19L1 | SNW1 | 0.995 | 0.234 | |
| ZNF830 | AQR | 0.994 | 0.666 |
structurally_consistent (dimer)
|
| USB1 | CDC40 | 0.992 | ||
| ESS2 | BUD31 | 0.991 | 0.15 | |
| AQR | KIAA1143 | 0.991 | 0.068 | |
| PPIE | CWF19L1 | 0.99 | 0.199333333333 | |
| AQR | PPIL1 | 0.99 | 0.398 |
structurally_consistent (dimer)
|
| ESS2 | PPIL1 | 0.989 | 0.068 | |
| AQR | USB1 | 0.988 |
structurally_consistent (Q9HCS7)
structurally_consistent (dimer) |
|
| CWF19L1 | USB1 | 0.987 | ||
| ESS2 | CWF19L1 | 0.986 | 0.072 | |
| AQR | CWF19L1 | 0.985 | 0.142 | |
| CWF19L1 | CDC40 | 0.983 | 0.082 | |
| PPIE | USB1 | 0.982 |
structurally_consistent (dimer)
|
|
| PPIL1 | CWF19L1 | 0.981 | 0.102 |
structurally_consistent (dimer)
|
| ZNF830 | CDC40 | 0.977 | 0.354 | |
| PPIL1 | BUD31 | 0.966 | 0.688 |
structurally_consistent (dimer)
|
| SNW1 | USB1 | 0.966 | ||
| KIAA1143 | BUD31 | 0.963 | 0.086 | |
| ZNF830 | BUD31 | 0.961 | 0.46 | |
| KIAA1143 | CDC40 | 0.957 | 0.09 | |
| CWF19L1 | BUD31 | 0.955 | 0.218 | |
| PPIE | KIAA1143 | 0.949 | 0.182 | |
| ZNF830 | SNW1 | 0.949 | 0.868 |
mutually_exclusive (O60306)
|
| ESS2 | ZNF830 | 0.788 | 0.248 | |
| ZNF830 | CWF19L1 | 0.771 | 0.652 | |
| ZNF830 | PPIL1 | 0.713 | 0.564 |
structurally_consistent (O60306)
|
| ZNF830 | KIAA1143 | 0.459 | 0.188 | |
| USB1 | BUD31 | 0.456 | ||
| KIAA1143 | SNW1 | 0.327 | 0.224 | |
| ESS2 | USB1 | 0.294 | ||
| PPIL1 | USB1 | 0.044 | ||
| ESS2 | KIAA1143 | 0.015 | 0.156 | |
| PPIL1 | KIAA1143 | 0.008 | 0.126 | |
| CWF19L1 | KIAA1143 | 0.006 | 0.142 |
Related Complexes