hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00355.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CACNB4 | Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4) | 5 | UniProt NCBI |
| CBARP | Voltage-dependent calcium channel beta subunit-associated regulatory protein | 5 | UniProt NCBI |
| CACNB3 | Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) | 5 | UniProt NCBI |
| CACNB2 | Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-112308 | 4.91023464396e-08 | 0.75 | CACNB2 CACNB4 CACNB3 | Presynaptic depolarization and calcium channel opening |
| GO:1901385 | 1.01987757791e-07 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | regulation of voltage-gated calcium channel activity |
| REAC:R-HSA-419037 | 4.0993398561e-06 | 0.75 | CACNB2 CACNB4 CACNB3 | NCAM1 interactions |
| GO:1901019 | 8.32139586928e-06 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | regulation of calcium ion transmembrane transporter activity |
| WP:WP2118 | 1.13301263399e-05 | 0.75 | CACNB2 CACNB4 CACNB3 | Arrhythmogenic right ventricular cardiomyopathy |
| REAC:R-HSA-375165 | 1.60766305396e-05 | 0.75 | CACNB2 CACNB4 CACNB3 | NCAM signaling for neurite out-growth |
| KEGG:05412 | 1.71467161414e-05 | 0.75 | CACNB2 CACNB4 CACNB3 | Arrhythmogenic right ventricular cardiomyopathy |
| KEGG:04260 | 2.04010593609e-05 | 0.75 | CACNB2 CACNB4 CACNB3 | Cardiac muscle contraction |
| KEGG:05414 | 2.40425716137e-05 | 0.75 | CACNB2 CACNB4 CACNB3 | Dilated cardiomyopathy |
| KEGG:05410 | 2.40425716137e-05 | 0.75 | CACNB2 CACNB4 CACNB3 | Hypertrophic cardiomyopathy |
| GO:2001257 | 3.3758447769e-05 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | regulation of cation channel activity |
| GO:1903169 | 8.74095077072e-05 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | regulation of calcium ion transmembrane transport |
| KEGG:04921 | 9.10876349728e-05 | 0.75 | CACNB2 CACNB4 CACNB3 | Oxytocin signaling pathway |
| KEGG:04261 | 9.34385249616e-05 | 0.75 | CACNB2 CACNB4 CACNB3 | Adrenergic signaling in cardiomyocytes |
| GO:0008331 | 0.000139871762976 | 0.75 | CACNB2 CACNB4 CACNB3 | high voltage-gated calcium channel activity |
| GO:0051924 | 0.000380561950422 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | regulation of calcium ion transport |
| WP:WP382 | 0.000461288756706 | 0.75 | CACNB2 CACNB4 CACNB3 | MAPK signaling pathway |
| GO:0032412 | 0.000464844728187 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | regulation of monoatomic ion transmembrane transporter activity |
| GO:0022898 | 0.000562407490821 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | regulation of transmembrane transporter activity |
| GO:0007528 | 0.000591522022343 | 0.75 | CACNB2 CACNB4 CACNB3 | neuromuscular junction development |
| GO:0032409 | 0.000745764165619 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | regulation of transporter activity |
| KEGG:04010 | 0.000800866642312 | 0.75 | CACNB2 CACNB4 CACNB3 | MAPK signaling pathway |
| GO:0070588 | 0.00113809141431 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | calcium ion transmembrane transport |
| GO:1904062 | 0.00113809141431 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | regulation of monoatomic cation transmembrane transport |
| GO:0034765 | 0.00166799059677 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | regulation of monoatomic ion transmembrane transport |
| GO:0005245 | 0.00172575455775 | 0.75 | CACNB2 CACNB4 CACNB3 | voltage-gated calcium channel activity |
| REAC:R-HSA-112315 | 0.00190780632503 | 0.75 | CACNB2 CACNB4 CACNB3 | Transmission across Chemical Synapses |
| GO:0005891 | 0.00209449363787 | 0.75 | CACNB2 CACNB4 CACNB3 | voltage-gated calcium channel complex |
| REAC:R-HSA-400042 | 0.00236402400204 | 0.5 | CACNB3 CACNB2 | Adrenaline,noradrenaline inhibits insulin secretion |
| GO:0010959 | 0.00263891757684 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | regulation of metal ion transport |
| GO:0006816 | 0.00354721473264 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | calcium ion transport |
| GO:0043269 | 0.0047455440478 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | regulation of monoatomic ion transport |
| REAC:R-HSA-112316 | 0.00603406960129 | 0.75 | CACNB2 CACNB4 CACNB3 | Neuronal System |
| GO:0034762 | 0.00613433997379 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | regulation of transmembrane transport |
| GO:0034704 | 0.0079870728422 | 0.75 | CACNB2 CACNB4 CACNB3 | calcium channel complex |
| GO:1901843 | 0.0168521501606 | 0.5 | CACNB3 CACNB2 | positive regulation of high voltage-gated calcium channel activity |
| REAC:R-HSA-422356 | 0.0212029570934 | 0.5 | CACNB3 CACNB2 | Regulation of insulin secretion |
| GO:0005262 | 0.0248327141789 | 0.75 | CACNB2 CACNB4 CACNB3 | calcium channel activity |
| REAC:R-HSA-422475 | 0.0253860120448 | 0.75 | CACNB2 CACNB4 CACNB3 | Axon guidance |
| REAC:R-HSA-9675108 | 0.0283171453534 | 0.75 | CACNB2 CACNB4 CACNB3 | Nervous system development |
| GO:0098662 | 0.0299356479586 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | inorganic cation transmembrane transport |
| GO:0098655 | 0.0311314419202 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | monoatomic cation transmembrane transport |
| GO:0022843 | 0.0339114962397 | 0.75 | CACNB2 CACNB4 CACNB3 | voltage-gated monoatomic cation channel activity |
| REAC:R-HSA-163685 | 0.041644107744 | 0.5 | CACNB3 CACNB2 | Integration of energy metabolism |
| GO:0098660 | 0.0416553027564 | 1.0 | CBARP CACNB2 CACNB4 CACNB3 | inorganic ion transmembrane transport |
| GO:0015085 | 0.0449670283878 | 0.75 | CACNB2 CACNB4 CACNB3 | calcium ion transmembrane transporter activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CACNB3 | CACNB2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CBARP | CACNB3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CACNB4 | CACNB3 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CACNB4 | CACNB2 | 0.902 | bioplex3_WMM WMM_only | |
| CACNB4 | CBARP | 0.768 | bioplex3_WMM WMM_only | |
| CBARP | CACNB2 | 0.754 | 0.09 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes