hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00372.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MBIP | MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein) | 5 | UniProt NCBI |
| KAT2B | Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57) | 5 | UniProt NCBI |
| KAT14 | Cysteine-rich protein 2-binding protein (CSRP2-binding protein) (ADA2A-containing complex subunit 2) (ATAC2) (CRP2-binding partner) (CRP2BP) (Lysine acetyltransferase 14) | 5 | UniProt NCBI |
| TADA3 | Transcriptional adapter 3 (ADA3 homolog) (hADA3) (STAF54) (Transcriptional adapter 3-like) (ADA3-like protein) | 5 | UniProt NCBI |
| YEATS2 | YEATS domain-containing protein 2 | 5 | UniProt NCBI |
| KAT2A | Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97) | 5 | UniProt NCBI |
| ZZZ3 | ZZ-type zinc finger-containing protein 3 | 5 | UniProt NCBI |
| TADA2A | Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) (ADA2-like protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6657 | 3.10345570391e-21 | 0.875 | KAT2A ZZZ3 TADA2A YEATS2 KAT14 TADA3 MBIP | ATAC complex, GCN5-linked |
| CORUM:6665 | 8.87375631601e-20 | 0.875 | KAT2A ZZZ3 TADA2A YEATS2 KAT14 TADA3 MBIP | ATAC complex, YEATS2-linked |
| GO:0140672 | 2.43155492989e-17 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | ATAC complex |
| GO:0090043 | 2.75510175035e-16 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | regulation of tubulin deacetylation |
| GO:0090042 | 1.09798995276e-15 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | tubulin deacetylation |
| REAC:R-HSA-9772755 | 1.12234039272e-15 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | Formation of WDR5-containing histone-modifying complexes |
| GO:0090311 | 2.41528829067e-15 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | regulation of protein deacetylation |
| GO:0006476 | 9.51601694825e-14 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | protein deacetylation |
| GO:0070461 | 1.18122777854e-13 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | SAGA-type complex |
| GO:0098732 | 3.81615940916e-13 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | macromolecule deacylation |
| GO:0035601 | 3.81615940916e-13 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | protein deacylation |
| GO:0045995 | 4.24903380349e-12 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | regulation of embryonic development |
| REAC:R-HSA-3214847 | 5.98480422042e-12 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | HATs acetylate histones |
| REAC:R-HSA-212165 | 4.47390440199e-11 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | Epigenetic regulation of gene expression |
| GO:0000123 | 8.95510478987e-11 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | histone acetyltransferase complex |
| GO:0031248 | 1.95033822998e-10 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | protein acetyltransferase complex |
| GO:1902493 | 1.95033822998e-10 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | acetyltransferase complex |
| GO:0051302 | 4.19788562258e-10 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | regulation of cell division |
| REAC:R-HSA-4839726 | 6.61356677712e-10 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | Chromatin organization |
| REAC:R-HSA-3247509 | 6.61356677712e-10 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | Chromatin modifying enzymes |
| GO:0072686 | 6.26242444318e-09 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | mitotic spindle |
| GO:0051301 | 1.03388790683e-07 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | cell division |
| GO:0005819 | 5.90173953873e-07 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | spindle |
| CORUM:471 | 1.17658221023e-06 | 0.375 | TADA2A KAT2B TADA3 | PCAF complex |
| CORUM:477 | 1.17658221023e-06 | 0.375 | TADA2A KAT2B TADA3 | PCAF complex |
| GO:0009790 | 4.82161498488e-06 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | embryo development |
| REAC:R-HSA-74160 | 6.70866002994e-05 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | Gene expression (Transcription) |
| GO:1990234 | 0.000446438652387 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | transferase complex |
| GO:2000026 | 0.000547212731684 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | regulation of multicellular organismal development |
| GO:0051726 | 0.000639086653122 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | regulation of cell cycle |
| GO:0140535 | 0.000666832615666 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | intracellular protein-containing complex |
| CORUM:6641 | 0.000668735194034 | 0.25 | KAT2A TADA3 | USP22-SAGA complex |
| GO:0031399 | 0.000928355783724 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | regulation of protein modification process |
| CORUM:438 | 0.00107416462378 | 0.25 | KAT2A TADA3 | GCN5-TRRAP histone acetyltransferase complex |
| CORUM:475 | 0.00157457895347 | 0.25 | KAT2A TADA3 | STAGA complex |
| CORUM:476 | 0.00186035657619 | 0.25 | KAT2A TADA3 | STAGA complex |
| GO:0000785 | 0.00212566298582 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | chromatin |
| GO:0015630 | 0.00285315545087 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | microtubule cytoskeleton |
| CORUM:445 | 0.00285973689486 | 0.25 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| CORUM:455 | 0.00285973689486 | 0.25 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| CORUM:456 | 0.00285973689486 | 0.25 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| CORUM:462 | 0.00285973689486 | 0.25 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| REAC:R-HSA-210744 | 0.0030606580132 | 0.25 | KAT2A KAT2B | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| REAC:R-HSA-8941856 | 0.0030606580132 | 0.25 | KAT2A KAT2B | RUNX3 regulates NOTCH signaling |
| GO:0032993 | 0.00320293753229 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | protein-DNA complex |
| CORUM:470 | 0.00324014777067 | 0.25 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| CORUM:513 | 0.00324014777067 | 0.25 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| CORUM:6643 | 0.00407177869695 | 0.25 | KAT2A TADA3 | SAGA complex, GCN5-linked |
| CORUM:6664 | 0.00407177869695 | 0.25 | KAT2A TADA3 | STAGA complex, SPT3-linked |
| REAC:R-HSA-9013695 | 0.00583667819665 | 0.25 | KAT2A KAT2B | NOTCH4 Intracellular Domain Regulates Transcription |
| GO:0000124 | 0.00712601113833 | 0.375 | KAT2A KAT2B TADA3 | SAGA complex |
| GO:0000122 | 0.00712874236673 | 0.75 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 | negative regulation of transcription by RNA polymerase II |
| REAC:R-HSA-9793380 | 0.00849789009901 | 0.25 | KAT2A KAT2B | Formation of paraxial mesoderm |
| REAC:R-HSA-9013508 | 0.0105471572959 | 0.25 | KAT2A KAT2B | NOTCH3 Intracellular Domain Regulates Transcription |
| GO:0007049 | 0.0126175578883 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | cell cycle |
| REAC:R-HSA-350054 | 0.0128161014463 | 0.25 | KAT2A KAT2B | Notch-HLH transcription pathway |
| KEGG:04330 | 0.0144579447004 | 0.25 | KAT2A KAT2B | Notch signaling pathway |
| WP:WP268 | 0.0149316061259 | 0.25 | KAT2A KAT2B | Notch signaling |
| REAC:R-HSA-186712 | 0.0166306183768 | 0.25 | KAT2A KAT2B | Regulation of beta-cell development |
| KEGG:03250 | 0.0204060704272 | 0.25 | KAT2A KAT2B | Viral life cycle - HIV-1 |
| GO:0005694 | 0.0263739534621 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | chromosome |
| GO:0004402 | 0.0291427400779 | 0.375 | KAT14 KAT2B KAT2A | histone acetyltransferase activity |
| GO:0050793 | 0.0316054677949 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | regulation of developmental process |
| GO:0061733 | 0.0349415747767 | 0.375 | KAT14 KAT2B KAT2A | peptide-lysine-N-acetyltransferase activity |
| REAC:R-HSA-9758941 | 0.0367988237757 | 0.25 | KAT2A KAT2B | Gastrulation |
| REAC:R-HSA-9012852 | 0.0409204105231 | 0.25 | KAT2A KAT2B | Signaling by NOTCH3 |
| REAC:R-HSA-2122947 | 0.04306231829 | 0.25 | KAT2A KAT2B | NOTCH1 Intracellular Domain Regulates Transcription |
| GO:0051246 | 0.0475013249603 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | regulation of protein metabolic process |
| GO:0005856 | 0.0483717117681 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | cytoskeleton |
| GO:1902494 | 0.049033393423 | 0.875 | KAT2A MBIP YEATS2 KAT2B KAT14 TADA3 ZZZ3 | catalytic complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TADA3 | ZZZ3 | 1.0 | 0.186 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| MBIP | ZZZ3 | 1.0 | 0.288 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| MBIP | TADA3 | 1.0 | 0.204 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| TADA3 | YEATS2 | 1.0 | 0.402 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| TADA3 | KAT2A | 1.0 | 0.286 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM |
| MBIP | YEATS2 | 1.0 | 0.186 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| MBIP | KAT14 | 0.999 | 0.282 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MBIP | KAT2A | 0.999 | 0.254 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KAT14 | TADA3 | 0.999 | 0.26 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| KAT2A | TADA2A | 0.999 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TADA3 | TADA2A | 0.999 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| YEATS2 | ZZZ3 | 0.999 | 0.318 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| YEATS2 | KAT2A | 0.999 | 0.248 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| MBIP | KAT2B | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KAT2A | ZZZ3 | 0.998 | 0.276 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| MBIP | TADA2A | 0.998 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ZZZ3 | TADA2A | 0.998 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| YEATS2 | TADA2A | 0.998 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| KAT2B | TADA3 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KAT14 | YEATS2 | 0.996 | 0.224 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| KAT14 | KAT2A | 0.996 | 0.268 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| KAT2B | KAT14 | 0.995 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| KAT14 | ZZZ3 | 0.991 | 0.304 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| KAT14 | TADA2A | 0.989 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| KAT2B | TADA2A | 0.986 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| KAT2B | YEATS2 | 0.985 | bioplex_WMM bioplex3_WMM WMM_only | |
| KAT2B | ZZZ3 | 0.98 | bioplex_WMM bioplex3_WMM WMM_only | |
| KAT2B | KAT2A | 0.944 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes