hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00381.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HECTD4 | HECT domain E3 ubiquitin protein ligase 4 | 1 | UniProt NCBI |
| GRIA4 | Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4) | 5 | UniProt NCBI |
| GRIA3 | Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (GluA3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-399710 | 4.09070097144e-05 | 0.666666666667 | GRIA4 GRIA3 | Activation of AMPA receptors |
| WP:WP5398 | 0.000103023242897 | 0.666666666667 | GRIA4 GRIA3 | NRXN1 deletion syndrome |
| WP:WP4760 | 0.000173183276299 | 0.666666666667 | GRIA4 GRIA3 | PKC gamma calcium signaling pathway in ataxia |
| KEGG:05033 | 0.000210478859947 | 0.666666666667 | GRIA4 GRIA3 | Nicotine addiction |
| REAC:R-HSA-416993 | 0.000449812862905 | 0.666666666667 | GRIA4 GRIA3 | Trafficking of GluR2-containing AMPA receptors |
| WP:WP2636 | 0.000561071903771 | 0.666666666667 | GRIA4 GRIA3 | Common pathways underlying drug addiction |
| REAC:R-HSA-438066 | 0.000926675585137 | 0.666666666667 | GRIA4 GRIA3 | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-8849932 | 0.00104246243986 | 0.666666666667 | GRIA4 GRIA3 | Synaptic adhesion-like molecules |
| KEGG:05031 | 0.00121528266465 | 0.666666666667 | GRIA4 GRIA3 | Amphetamine addiction |
| HP:0000322 | 0.00168814156034 | 1.0 | GRIA4 HECTD4 GRIA3 | Short philtrum |
| KEGG:04713 | 0.0019996401701 | 0.666666666667 | GRIA4 GRIA3 | Circadian entrainment |
| WP:WP3584 | 0.00199965110325 | 0.666666666667 | GRIA4 GRIA3 | MECP2 and associated Rett syndrome |
| REAC:R-HSA-399719 | 0.00204339075673 | 0.666666666667 | GRIA4 GRIA3 | Trafficking of AMPA receptors |
| REAC:R-HSA-399721 | 0.00204339075673 | 0.666666666667 | GRIA4 GRIA3 | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| HP:0000400 | 0.0020454007022 | 1.0 | GRIA4 HECTD4 GRIA3 | Macrotia |
| KEGG:04724 | 0.0024644071062 | 0.666666666667 | GRIA4 GRIA3 | Glutamatergic synapse |
| KEGG:04728 | 0.00447126662273 | 0.666666666667 | GRIA4 GRIA3 | Dopaminergic synapse |
| KEGG:04723 | 0.00533101781525 | 0.666666666667 | GRIA4 GRIA3 | Retrograde endocannabinoid signaling |
| WP:WP5083 | 0.00688101165686 | 0.666666666667 | GRIA4 GRIA3 | Neuroinflammation and glutamatergic signaling |
| GO:0004971 | 0.00842684400117 | 0.666666666667 | GRIA4 GRIA3 | AMPA glutamate receptor activity |
| KEGG:04024 | 0.00940070336911 | 0.666666666667 | GRIA4 GRIA3 | cAMP signaling pathway |
| KEGG:04080 | 0.0131637332902 | 0.666666666667 | GRIA4 GRIA3 | Neuroactive ligand-receptor interaction |
| REAC:R-HSA-6794362 | 0.0164154902665 | 0.666666666667 | GRIA4 GRIA3 | Protein-protein interactions at synapses |
| REAC:R-HSA-442755 | 0.0214696523361 | 0.666666666667 | GRIA4 GRIA3 | Activation of NMDA receptors and postsynaptic events |
| KEGG:05016 | 0.0275851821163 | 0.666666666667 | GRIA4 GRIA3 | Huntington disease |
| GO:0099507 | 0.0294899169624 | 0.666666666667 | GRIA4 GRIA3 | ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential |
| HP:0000288 | 0.0364325748731 | 1.0 | GRIA4 HECTD4 GRIA3 | Abnormality of the philtrum |
| WP:WP5420 | 0.0379798583444 | 0.666666666667 | GRIA4 GRIA3 | ADHD and autism ASD linked metabolic pathways and SNP |
| HP:0007370 | 0.0449808704429 | 1.0 | GRIA4 HECTD4 GRIA3 | Aplasia/Hypoplasia of the corpus callosum |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GRIA4 | GRIA3 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| HECTD4 | huMAP3_00381.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_11206.1 huMAP3_11737.1 huMAP3_12440.1 |
| GRIA4 | huMAP3_00381.1 huMAP3_12440.1 huMAP3_13308.1 |
| GRIA3 | huMAP3_00381.1 huMAP3_12440.1 huMAP3_13308.1 |