hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00385.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CFH | Complement factor H (H factor 1) | 5 | UniProt NCBI |
| CFHR3 | Complement factor H-related protein 3 (FHR-3) (DOWN16) (H factor-like protein 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0005369 | 2.05051410255e-05 | 1.0 | CFH CFHR3 | Decreased circulating complement factor H concentration |
| HP:0005416 | 3.41752350426e-05 | 1.0 | CFH CFHR3 | Decreased circulating complement factor B concentration |
| HP:0005356 | 3.41752350426e-05 | 1.0 | CFH CFHR3 | Decreased circulating complement factor I concentration |
| HP:0025574 | 7.17679935894e-05 | 1.0 | CFH CFHR3 | Macular hemorrhage |
| HP:0030499 | 9.56906581192e-05 | 1.0 | CFH CFHR3 | Macular drusen |
| HP:0001937 | 0.000153788557692 | 1.0 | CFH CFHR3 | Microangiopathic hemolytic anemia |
| HP:0001981 | 0.000187963792734 | 1.0 | CFH CFHR3 | Schistocytosis |
| HP:0100519 | 0.000225556551281 | 1.0 | CFH CFHR3 | Anuria |
| HP:0005575 | 0.000310994638887 | 1.0 | CFH CFHR3 | Hemolytic-uremic syndrome |
| KEGG:04610 | 0.000403985690766 | 1.0 | CFH CFHR3 | Complement and coagulation cascades |
| HP:0030500 | 0.000464783196579 | 1.0 | CFH CFHR3 | Yellow/white lesions of the macula |
| HP:0011506 | 0.000522881096151 | 1.0 | CFH CFHR3 | Choroidal neovascularization |
| HP:0031970 | 0.000584396519228 | 1.0 | CFH CFHR3 | Abnormal blood urea nitrogen concentration |
| HP:0003138 | 0.000584396519228 | 1.0 | CFH CFHR3 | Increased blood urea nitrogen |
| HP:0025568 | 0.000864633446577 | 1.0 | CFH CFHR3 | Abnormal morphology of the choroidal vasculature |
| HP:0011510 | 0.000943236487175 | 1.0 | CFH CFHR3 | Drusen |
| HP:0031803 | 0.00119955074999 | 1.0 | CFH CFHR3 | Fundus hemorrhage |
| HP:0000573 | 0.00119955074999 | 1.0 | CFH CFHR3 | Retinal hemorrhage |
| HP:0011037 | 0.00129182388461 | 1.0 | CFH CFHR3 | Decreased urine output |
| REAC:R-HSA-977606 | 0.00140118463675 | 1.0 | CFH CFHR3 | Regulation of Complement cascade |
| HP:0001919 | 0.00148662272435 | 1.0 | CFH CFHR3 | Acute kidney injury |
| HP:0005421 | 0.00158914842948 | 1.0 | CFH CFHR3 | Decreased circulating complement C3 concentration |
| REAC:R-HSA-166658 | 0.0019274832564 | 1.0 | CFH CFHR3 | Complement cascade |
| HP:0001923 | 0.00240251902349 | 1.0 | CFH CFHR3 | Reticulocytosis |
| HP:0008002 | 0.00240251902349 | 1.0 | CFH CFHR3 | Abnormality of macular pigmentation |
| HP:0003259 | 0.00308602372434 | 1.0 | CFH CFHR3 | Elevated circulating creatinine concentration |
| HP:0004431 | 0.00308602372434 | 1.0 | CFH CFHR3 | Complement deficiency |
| HP:0011885 | 0.00338334826922 | 1.0 | CFH CFHR3 | Hemorrhage of the eye |
| HP:0005339 | 0.00353713682691 | 1.0 | CFH CFHR3 | Abnormality of complement system |
| HP:0004447 | 0.0036943429081 | 1.0 | CFH CFHR3 | Poikilocytosis |
| HP:0012100 | 0.0036943429081 | 1.0 | CFH CFHR3 | Abnormal circulating creatinine concentration |
| HP:0030506 | 0.0038549665128 | 1.0 | CFH CFHR3 | Yellow/white lesions of the retina |
| HP:0012590 | 0.00401900764101 | 1.0 | CFH CFHR3 | Abnormal urine output |
| HP:0011036 | 0.00453163616665 | 1.0 | CFH CFHR3 | Abnormality of renal excretion |
| HP:0004312 | 0.009230730985 | 1.0 | CFH CFHR3 | Abnormal reticulocyte morphology |
| HP:0000608 | 0.0102628230833 | 1.0 | CFH CFHR3 | Macular degeneration |
| HP:0002381 | 0.0119134869358 | 1.0 | CFH CFHR3 | Aphasia |
| HP:0001269 | 0.0119134869358 | 1.0 | CFH CFHR3 | Hemiparesis |
| HP:0001105 | 0.0122005589102 | 1.0 | CFH CFHR3 | Retinal atrophy |
| HP:0001259 | 0.0139947587499 | 1.0 | CFH CFHR3 | Coma |
| HP:0000529 | 0.0165784065192 | 1.0 | CFH CFHR3 | Progressive visual loss |
| HP:0000979 | 0.0190185183012 | 1.0 | CFH CFHR3 | Purpura |
| HP:0003584 | 0.0193807757926 | 1.0 | CFH CFHR3 | Late onset |
| GO:0001851 | 0.0210690324038 | 1.0 | CFH CFHR3 | complement component C3b binding |
| HP:0001878 | 0.0248112206409 | 1.0 | CFH CFHR3 | Hemolytic anemia |
| HP:0011895 | 0.0260620342435 | 1.0 | CFH CFHR3 | Anemia due to reduced life span of red cells |
| HP:0003077 | 0.0277776310426 | 1.0 | CFH CFHR3 | Hyperlipidemia |
| HP:0002157 | 0.0376816141579 | 1.0 | CFH CFHR3 | Azotemia |
| HP:0004364 | 0.042927512737 | 1.0 | CFH CFHR3 | Abnormal circulating nitrogen compound concentration |
| HP:0000610 | 0.0473702932925 | 1.0 | CFH CFHR3 | Abnormal choroid morphology |
| HP:0001103 | 0.0490927251387 | 1.0 | CFH CFHR3 | Abnormal macular morphology |
| HP:0005389 | 0.0499436884913 | 0.5 | CFH | Depletion of components of the alternative complement pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CFH | CFHR3 | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| CFH | huMAP3_00385.1 huMAP3_10678.1 huMAP3_15040.1 huMAP3_15228.1 |
| CFHR3 | huMAP3_00385.1 huMAP3_15228.1 |