hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00399.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RPS4Y2 | Small ribosomal subunit protein eS4, Y isoform 2 (40S ribosomal protein S4, Y isoform 2) | 2 | UniProt NCBI |
| RPS4Y1 | Small ribosomal subunit protein eS4, Y isoform 1 (40S ribosomal protein S4) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9735869 | 0.00113803532692 | 1.0 | RPS4Y2 RPS4Y1 | SARS-CoV-1 modulates host translation machinery |
| KEGG:03010 | 0.00136314688816 | 1.0 | RPS4Y2 RPS4Y1 | Ribosome |
| REAC:R-HSA-9754678 | 0.00217867123396 | 1.0 | RPS4Y2 RPS4Y1 | SARS-CoV-2 modulates host translation machinery |
| REAC:R-HSA-72695 | 0.00226581808332 | 1.0 | RPS4Y2 RPS4Y1 | Formation of the ternary complex, and subsequently, the 43S complex |
| REAC:R-HSA-72649 | 0.00292369135789 | 1.0 | RPS4Y2 RPS4Y1 | Translation initiation complex formation |
| REAC:R-HSA-72702 | 0.00292369135789 | 1.0 | RPS4Y2 RPS4Y1 | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72662 | 0.00302450830127 | 1.0 | RPS4Y2 RPS4Y1 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| KEGG:05171 | 0.0033003273675 | 1.0 | RPS4Y2 RPS4Y1 | Coronavirus disease - COVID-19 |
| REAC:R-HSA-192823 | 0.00654113998715 | 1.0 | RPS4Y2 RPS4Y1 | Viral mRNA Translation |
| REAC:R-HSA-156902 | 0.00654113998715 | 1.0 | RPS4Y2 RPS4Y1 | Peptide chain elongation |
| REAC:R-HSA-2408557 | 0.00699737937497 | 1.0 | RPS4Y2 RPS4Y1 | Selenocysteine synthesis |
| REAC:R-HSA-72764 | 0.00699737937497 | 1.0 | RPS4Y2 RPS4Y1 | Eukaryotic Translation Termination |
| REAC:R-HSA-156842 | 0.00715287669441 | 1.0 | RPS4Y2 RPS4Y1 | Eukaryotic Translation Elongation |
| REAC:R-HSA-9692914 | 0.00731008277561 | 1.0 | RPS4Y2 RPS4Y1 | SARS-CoV-1-host interactions |
| REAC:R-HSA-975956 | 0.00746899761856 | 1.0 | RPS4Y2 RPS4Y1 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| REAC:R-HSA-9633012 | 0.00845837067304 | 1.0 | RPS4Y2 RPS4Y1 | Response of EIF2AK4 (GCN2) to amino acid deficiency |
| REAC:R-HSA-72689 | 0.00845837067304 | 1.0 | RPS4Y2 RPS4Y1 | Formation of a pool of free 40S subunits |
| REAC:R-HSA-1799339 | 0.010244026704 | 1.0 | RPS4Y2 RPS4Y1 | SRP-dependent cotranslational protein targeting to membrane |
| REAC:R-HSA-156827 | 0.010244026704 | 1.0 | RPS4Y2 RPS4Y1 | L13a-mediated translational silencing of Ceruloplasmin expression |
| REAC:R-HSA-2408522 | 0.0104319904967 | 1.0 | RPS4Y2 RPS4Y1 | Selenoamino acid metabolism |
| REAC:R-HSA-72706 | 0.0104319904967 | 1.0 | RPS4Y2 RPS4Y1 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| REAC:R-HSA-927802 | 0.0110061344455 | 1.0 | RPS4Y2 RPS4Y1 | Nonsense-Mediated Decay (NMD) |
| REAC:R-HSA-975957 | 0.0110061344455 | 1.0 | RPS4Y2 RPS4Y1 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-72613 | 0.0117955823749 | 1.0 | RPS4Y2 RPS4Y1 | Eukaryotic Translation Initiation |
| REAC:R-HSA-72737 | 0.0117955823749 | 1.0 | RPS4Y2 RPS4Y1 | Cap-dependent Translation Initiation |
| REAC:R-HSA-168273 | 0.0145501063194 | 1.0 | RPS4Y2 RPS4Y1 | Influenza Viral RNA Transcription and Replication |
| REAC:R-HSA-9678108 | 0.0147739541089 | 1.0 | RPS4Y2 RPS4Y1 | SARS-CoV-1 Infection |
| REAC:R-HSA-168255 | 0.0185879103397 | 1.0 | RPS4Y2 RPS4Y1 | Influenza Infection |
| REAC:R-HSA-9711097 | 0.0198694816538 | 1.0 | RPS4Y2 RPS4Y1 | Cellular response to starvation |
| REAC:R-HSA-9010553 | 0.0234014921954 | 1.0 | RPS4Y2 RPS4Y1 | Regulation of expression of SLITs and ROBOs |
| REAC:R-HSA-6791226 | 0.0275281518268 | 1.0 | RPS4Y2 RPS4Y1 | Major pathway of rRNA processing in the nucleolus and cytosol |
| REAC:R-HSA-9705683 | 0.0300366140789 | 1.0 | RPS4Y2 RPS4Y1 | SARS-CoV-2-host interactions |
| REAC:R-HSA-8868773 | 0.0306808172595 | 1.0 | RPS4Y2 RPS4Y1 | rRNA processing in the nucleus and cytosol |
| REAC:R-HSA-72312 | 0.0340043588674 | 1.0 | RPS4Y2 RPS4Y1 | rRNA processing |
| REAC:R-HSA-376176 | 0.0374987766505 | 1.0 | RPS4Y2 RPS4Y1 | Signaling by ROBO receptors |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RPS4Y2 | RPS4Y1 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| RPS4Y2 | huMAP3_00399.1 huMAP3_01196.1 huMAP3_05607.1 huMAP3_11090.1 |
| RPS4Y1 | huMAP3_00399.1 huMAP3_01923.1 huMAP3_11090.1 huMAP3_13090.1 |