hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00410.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLCO1B3 | Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (OATP1B3) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8) | 5 | UniProt NCBI |
| SLCO1B1 | Solute carrier organic anion transporter family member 1B1 (SLCO1B1) (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Organic anion transporter SLC21A6) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0031811 | 3.41752350426e-06 | 1.0 | SLCO1B3 SLCO1B1 | Bilirubinuria |
| WP:WP5396 | 1.91536658216e-05 | 1.0 | SLCO1B3 SLCO1B1 | Enterohepatic circulation of bile acids |
| WP:WP5368 | 1.91536658216e-05 | 1.0 | SLCO1B3 SLCO1B1 | Sulfatase and aromatase pathway |
| REAC:R-HSA-879518 | 2.56314262819e-05 | 1.0 | SLCO1B3 SLCO1B1 | Transport of organic anions |
| HP:0001046 | 3.41752350426e-05 | 1.0 | SLCO1B3 SLCO1B1 | Intermittent jaundice |
| REAC:R-HSA-9754706 | 4.78453290596e-05 | 1.0 | SLCO1B3 SLCO1B1 | Atorvastatin ADME |
| HP:0032106 | 5.12628525639e-05 | 1.0 | SLCO1B3 SLCO1B1 | Conjunctival icterus |
| WP:WP5176 | 5.7886634483e-05 | 1.0 | SLCO1B3 SLCO1B1 | Disorders of bile acid synthesis and biliary transport |
| HP:0010473 | 9.56906581192e-05 | 1.0 | SLCO1B3 SLCO1B1 | Porphyrinuria |
| REAC:R-HSA-189483 | 0.000112778275641 | 1.0 | SLCO1B3 SLCO1B1 | Heme degradation |
| REAC:R-HSA-159418 | 0.000112778275641 | 1.0 | SLCO1B3 SLCO1B1 | Recycling of bile acids and salts |
| HP:0010984 | 0.000266566833332 | 1.0 | SLCO1B3 SLCO1B1 | Digenic inheritance |
| KEGG:04976 | 0.000268727704965 | 1.0 | SLCO1B3 SLCO1B1 | Bile secretion |
| REAC:R-HSA-189445 | 0.000394723964742 | 1.0 | SLCO1B3 SLCO1B1 | Metabolism of porphyrins |
| REAC:R-HSA-194068 | 0.000693757271364 | 1.0 | SLCO1B3 SLCO1B1 | Bile acid and bile salt metabolism |
| REAC:R-HSA-425397 | 0.000847545829056 | 1.0 | SLCO1B3 SLCO1B1 | Transport of vitamins, nucleosides, and related molecules |
| HP:0002908 | 0.00102525705128 | 1.0 | SLCO1B3 SLCO1B1 | Conjugated hyperbilirubinemia |
| REAC:R-HSA-5619102 | 0.00412665963139 | 1.0 | SLCO1B3 SLCO1B1 | SLC transporter disorders |
| REAC:R-HSA-9748784 | 0.0055363880769 | 1.0 | SLCO1B3 SLCO1B1 | Drug ADME |
| HP:0001426 | 0.00849254590808 | 1.0 | SLCO1B3 SLCO1B1 | Non-Mendelian inheritance |
| GO:0015347 | 0.00983221512175 | 1.0 | SLCO1B3 SLCO1B1 | sodium-independent organic anion transmembrane transporter activity |
| REAC:R-HSA-8957322 | 0.0126123704925 | 1.0 | SLCO1B3 SLCO1B1 | Metabolism of steroids |
| GO:0043252 | 0.0131096201623 | 1.0 | SLCO1B3 SLCO1B1 | sodium-independent organic anion transport |
| HP:0002904 | 0.0159119894358 | 1.0 | SLCO1B3 SLCO1B1 | Hyperbilirubinemia |
| HP:0033479 | 0.0162434892157 | 1.0 | SLCO1B3 SLCO1B1 | Abnormal circulating bilirubin concentration |
| GO:0046149 | 0.016855225923 | 1.0 | SLCO1B3 SLCO1B1 | pigment catabolic process |
| GO:0042167 | 0.016855225923 | 1.0 | SLCO1B3 SLCO1B1 | heme catabolic process |
| GO:0015125 | 0.016855225923 | 1.0 | SLCO1B3 SLCO1B1 | bile acid transmembrane transporter activity |
| REAC:R-HSA-5619115 | 0.0168654784935 | 1.0 | SLCO1B3 SLCO1B1 | Disorders of transmembrane transporters |
| HP:0000989 | 0.020488053408 | 1.0 | SLCO1B3 SLCO1B1 | Pruritus |
| GO:0006787 | 0.0210690324038 | 1.0 | SLCO1B3 SLCO1B1 | porphyrin-containing compound catabolic process |
| GO:0033015 | 0.0210690324038 | 1.0 | SLCO1B3 SLCO1B1 | tetrapyrrole catabolic process |
| REAC:R-HSA-425407 | 0.0217354494871 | 1.0 | SLCO1B3 SLCO1B1 | SLC-mediated transmembrane transport |
| REAC:R-HSA-5619058 | 0.0249718442457 | 0.5 | SLCO1B3 | Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) |
| REAC:R-HSA-5619110 | 0.0249718442457 | 0.5 | SLCO1B1 | Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) |
| HP:0010995 | 0.0252247409849 | 1.0 | SLCO1B3 SLCO1B1 | Abnormal circulating dicarboxylic acid concentration |
| GO:0015721 | 0.0309012475255 | 1.0 | SLCO1B3 SLCO1B1 | bile acid and bile salt transport |
| HP:0000502 | 0.033730956987 | 1.0 | SLCO1B3 SLCO1B1 | Abnormal conjunctiva morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SLCO1B3 | SLCO1B1 | 0.992 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| SLCO1B3 | huMAP3_00410.1 huMAP3_12903.1 huMAP3_14030.1 huMAP3_15199.1 |
| SLCO1B1 | huMAP3_00410.1 huMAP3_12903.1 huMAP3_14030.1 huMAP3_15199.1 |