hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00413.1
Complex Portal: CPX-12246
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MLF2 | Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2) | 4 | UniProt NCBI |
| HSPA1B | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) | 5 | UniProt NCBI |
| HERC4 | Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4) | 5 | UniProt NCBI |
| DNAJC7 | DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3371453 | 0.0212029570934 | 0.5 | DNAJC7 HSPA1B | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-3371556 | 0.0363250695065 | 0.5 | DNAJC7 HSPA1B | Cellular response to heat stress |
| CORUM:6399 | 0.049938562206 | 0.25 | DNAJC7 | DNAJC7-HSPA8-HSP90AA1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| HSPA1B | DNAJC7 | 0.994 | 0.362 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM | |
| MLF2 | HSPA1B | 0.988 | 0.106 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| HERC4 | HSPA1B | 0.976 | 0.106 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| MLF2 | DNAJC7 | 0.962 | 0.02 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | |
| HERC4 | DNAJC7 | 0.941 | 0.054 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| HERC4 | MLF2 | 0.729 | 0.022 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes