hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00424.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NCDN | Neurochondrin | 5 | UniProt NCBI |
| ECD | Protein ecdysoneless homolog (Human suppressor of GCR two) (hSGT1) | 5 | UniProt NCBI |
| EFTUD2 | 116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa) | 5 | UniProt NCBI |
| SNRNP40 | U5 small nuclear ribonucleoprotein 40 kDa protein (U5 snRNP 40 kDa protein) (U5-40K) (38 kDa-splicing factor) (Prp8-binding protein) (hPRP8BP) (U5 snRNP-specific 40 kDa protein) (WD repeat-containing protein 57) | 5 | UniProt NCBI |
| WDR83 | WD repeat domain-containing protein 83 (Mitogen-activated protein kinase organizer 1) (MAPK organizer 1) | 5 | UniProt NCBI |
| RSRC1 | Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1) | 5 | UniProt NCBI |
| EAPP | E2F-associated phosphoprotein (EAPP) | 5 | UniProt NCBI |
| AAR2 | Protein AAR2 homolog (AAR2 splicing factor homolog) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1181 | 0.000704977993915 | 0.375 | SNRNP40 EFTUD2 WDR83 | C complex spliceosome |
| GO:0000377 | 0.00515127841025 | 0.625 | SNRNP40 RSRC1 AAR2 EFTUD2 WDR83 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.00515127841025 | 0.625 | SNRNP40 RSRC1 AAR2 EFTUD2 WDR83 | mRNA splicing, via spliceosome |
| GO:0000375 | 0.00554969026619 | 0.625 | SNRNP40 RSRC1 AAR2 EFTUD2 WDR83 | RNA splicing, via transesterification reactions |
| GO:0006397 | 0.0162523964013 | 0.625 | SNRNP40 RSRC1 AAR2 EFTUD2 WDR83 | mRNA processing |
| GO:0008380 | 0.0252266107187 | 0.625 | SNRNP40 RSRC1 AAR2 EFTUD2 WDR83 | RNA splicing |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EFTUD2 | AAR2 | 1.0 | 0.679 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| EAPP | AAR2 | 1.0 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM |
| ECD | EAPP | 1.0 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| EFTUD2 | EAPP | 0.999 | 0.212 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 boldt_WMM |
| EFTUD2 | SNRNP40 | 0.999 | 0.788 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| ECD | AAR2 | 0.999 | 0.048 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| ECD | EFTUD2 | 0.999 | 0.273674178404 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NCDN | ECD | 0.999 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NCDN | AAR2 | 0.999 | 0.07 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| WDR83 | EAPP | 0.998 | 0.188 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| NCDN | SNRNP40 | 0.998 | 0.028 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| NCDN | EAPP | 0.996 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| SNRNP40 | AAR2 | 0.994 | 0.354 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 boldt_WMM |
| WDR83 | SNRNP40 | 0.994 | 0.338 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| SNRNP40 | RSRC1 | 0.993 | 0.39 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| WDR83 | EFTUD2 | 0.99 | 0.228 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| SNRNP40 | EAPP | 0.987 | 0.148 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 boldt_WMM |
| ECD | SNRNP40 | 0.985 | 0.012 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NCDN | EFTUD2 | 0.976 | 0.202 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| WDR83 | ECD | 0.97 | 0.042 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| WDR83 | AAR2 | 0.937 | 0.134 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| EFTUD2 | RSRC1 | 0.818 | 0.558666666667 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| WDR83 | NCDN | 0.609 | 0.07 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| ECD | RSRC1 | 0.59 | 0.074 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| RSRC1 | EAPP | 0.488 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only |
| NCDN | RSRC1 | 0.466 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only |
| WDR83 | RSRC1 | 0.448 | 0.134 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| RSRC1 | AAR2 | 0.443 | 0.232 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes