hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00432.1
Complex Portal: CPX-19491
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AP2A2 | AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) | 5 | UniProt NCBI |
| ITSN2 | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) | 5 | UniProt NCBI |
| AP2B1 | AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) | 5 | UniProt NCBI |
| CCDC32 | Coiled-coil domain-containing protein 32 | 5 | UniProt NCBI |
| AAGAB | Alpha- and gamma-adaptin-binding protein p34 | 5 | UniProt NCBI |
| NECAP2 | Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2) | 4 | UniProt NCBI |
| EPS15L1 | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | 5 | UniProt NCBI |
| ITSN1 | Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) | 5 | UniProt NCBI |
| AP2S1 | AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005905 | 1.18452885206e-12 | 0.777777777778 | EPS15L1 NECAP2 AP2S1 CCDC32 AP2A2 ITSN1 AP2B1 | clathrin-coated pit |
| REAC:R-HSA-8856825 | 3.06224180449e-12 | 0.777777777778 | EPS15L1 NECAP2 AP2S1 AP2A2 AP2B1 ITSN1 ITSN2 | Cargo recognition for clathrin-mediated endocytosis |
| REAC:R-HSA-8856828 | 3.90782046255e-11 | 0.777777777778 | EPS15L1 NECAP2 AP2S1 AP2A2 AP2B1 ITSN1 ITSN2 | Clathrin-mediated endocytosis |
| GO:0072583 | 1.38809802007e-09 | 0.666666666667 | AP2S1 CCDC32 AP2A2 ITSN1 AP2B1 ITSN2 | clathrin-dependent endocytosis |
| GO:0006897 | 3.7030020776e-07 | 0.888888888889 | EPS15L1 NECAP2 AP2S1 CCDC32 AP2A2 ITSN1 AP2B1 ITSN2 | endocytosis |
| GO:0030118 | 6.48174432462e-07 | 0.555555555556 | EPS15L1 NECAP2 AP2S1 AP2A2 AP2B1 | clathrin coat |
| REAC:R-HSA-199991 | 1.09440243787e-06 | 0.777777777778 | EPS15L1 NECAP2 AP2S1 AP2A2 AP2B1 ITSN1 ITSN2 | Membrane Trafficking |
| REAC:R-HSA-182218 | 1.33765378004e-06 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | Nef Mediated CD8 Down-regulation |
| REAC:R-HSA-5653656 | 1.59774106483e-06 | 0.777777777778 | EPS15L1 NECAP2 AP2S1 AP2A2 AP2B1 ITSN1 ITSN2 | Vesicle-mediated transport |
| GO:0030132 | 1.6375274005e-06 | 0.444444444444 | EPS15L1 AP2S1 AP2A2 AP2B1 | clathrin coat of coated pit |
| REAC:R-HSA-167590 | 3.20839170288e-06 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | Nef Mediated CD4 Down-regulation |
| GO:0098657 | 3.21471063629e-06 | 0.888888888889 | EPS15L1 NECAP2 AP2S1 CCDC32 AP2A2 ITSN1 AP2B1 ITSN2 | import into cell |
| REAC:R-HSA-177504 | 8.39516773096e-06 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | Retrograde neurotrophin signalling |
| REAC:R-HSA-5140745 | 1.09103559608e-05 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
| REAC:R-HSA-5099900 | 1.73466913202e-05 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | WNT5A-dependent internalization of FZD4 |
| GO:0006898 | 1.81410356673e-05 | 0.666666666667 | AP2S1 CCDC32 AP2A2 ITSN1 AP2B1 ITSN2 | receptor-mediated endocytosis |
| REAC:R-HSA-8866427 | 2.1343196228e-05 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | VLDLR internalisation and degradation |
| REAC:R-HSA-2682334 | 2.69008286706e-05 | 0.444444444444 | ITSN1 AP2S1 AP2A2 AP2B1 | EPH-Ephrin signaling |
| WP:WP4159 | 2.96287331638e-05 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | GABA receptor signaling |
| REAC:R-HSA-8964038 | 3.10809244976e-05 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | LDL clearance |
| GO:0048475 | 4.11428574507e-05 | 0.555555555556 | EPS15L1 NECAP2 AP2S1 AP2A2 AP2B1 | coated membrane |
| GO:0030117 | 4.11428574507e-05 | 0.555555555556 | EPS15L1 NECAP2 AP2S1 AP2A2 AP2B1 | membrane coat |
| REAC:R-HSA-164938 | 5.0612044968e-05 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| GO:0030125 | 7.82064017367e-05 | 0.444444444444 | NECAP2 AP2S1 AP2A2 AP2B1 | clathrin vesicle coat |
| REAC:R-HSA-164952 | 0.000111102783725 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | The role of Nef in HIV-1 replication and disease pathogenesis |
| GO:0099003 | 0.000123522310574 | 0.555555555556 | ITSN1 ITSN2 AP2S1 AP2A2 AP2B1 | vesicle-mediated transport in synapse |
| KEGG:04961 | 0.00013059415819 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | Endocrine and other factor-regulated calcium reabsorption |
| WP:WP2267 | 0.000179600985894 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | Synaptic vesicle pathway |
| REAC:R-HSA-8964043 | 0.000188109751173 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | Plasma lipoprotein clearance |
| KEGG:04721 | 0.000274501573283 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | Synaptic vesicle cycle |
| GO:0140239 | 0.000282244947588 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | postsynaptic endocytosis |
| GO:0098884 | 0.000282244947588 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | postsynaptic neurotransmitter receptor internalization |
| KEGG:04144 | 0.000364002806131 | 0.444444444444 | EPS15L1 AP2S1 AP2A2 AP2B1 | Endocytosis |
| GO:0016192 | 0.000416452857451 | 0.888888888889 | EPS15L1 NECAP2 AP2S1 CCDC32 AP2A2 ITSN1 AP2B1 ITSN2 | vesicle-mediated transport |
| GO:0030128 | 0.00045145282213 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | clathrin coat of endocytic vesicle |
| GO:0030122 | 0.00045145282213 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | AP-2 adaptor complex |
| GO:0048488 | 0.000488457397695 | 0.444444444444 | ITSN2 AP2S1 AP2B1 ITSN1 | synaptic vesicle endocytosis |
| GO:0140238 | 0.000488457397695 | 0.444444444444 | ITSN2 AP2S1 AP2B1 ITSN1 | presynaptic endocytosis |
| REAC:R-HSA-3928665 | 0.000500428099492 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | EPH-ephrin mediated repulsion of cells |
| REAC:R-HSA-437239 | 0.000573226646465 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | Recycling pathway of L1 |
| GO:0036465 | 0.00103422373522 | 0.444444444444 | ITSN2 AP2S1 AP2B1 ITSN1 | synaptic vesicle recycling |
| REAC:R-HSA-174824 | 0.00128664481505 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | Plasma lipoprotein assembly, remodeling, and clearance |
| GO:0030120 | 0.0012907232035 | 0.444444444444 | NECAP2 AP2S1 AP2A2 AP2B1 | vesicle coat |
| GO:0099590 | 0.00177138039123 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | neurotransmitter receptor internalization |
| GO:0035615 | 0.00292902387419 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | clathrin adaptor activity |
| GO:0140312 | 0.00366015186856 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | cargo adaptor activity |
| REAC:R-HSA-9679191 | 0.00368511987685 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | Potential therapeutics for SARS |
| REAC:R-HSA-4086400 | 0.00452422603622 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | PCP/CE pathway |
| REAC:R-HSA-187037 | 0.00548064743149 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-373760 | 0.00637258740182 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | L1CAM interactions |
| GO:0036020 | 0.00655807506899 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | endolysosome membrane |
| GO:0030131 | 0.00655807506899 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | clathrin adaptor complex |
| WP:WP437 | 0.00687451094998 | 0.333333333333 | EPS15L1 AP2B1 AP2S1 | EGF EGFR signaling pathway |
| REAC:R-HSA-166520 | 0.00889169623462 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | Signaling by NTRKs |
| GO:0030665 | 0.0090427452869 | 0.444444444444 | NECAP2 AP2S1 AP2A2 AP2B1 | clathrin-coated vesicle membrane |
| REAC:R-HSA-2132295 | 0.00960997261146 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | MHC class II antigen presentation |
| REAC:R-HSA-162909 | 0.0117096205899 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | Host Interactions of HIV factors |
| WP:WP4829 | 0.012380386891 | 0.222222222222 | AP2A2 AP2B1 | mBDNF and proBDNF regulation of GABA neurotransmission |
| REAC:R-HSA-3858494 | 0.0150593300182 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | Beta-catenin independent WNT signaling |
| GO:0099504 | 0.0154150912184 | 0.444444444444 | ITSN2 AP2S1 AP2B1 ITSN1 | synaptic vesicle cycle |
| GO:0150007 | 0.016855225923 | 0.222222222222 | ITSN2 ITSN1 | clathrin-dependent synaptic vesicle endocytosis |
| REAC:R-HSA-9006934 | 0.0199771648526 | 0.444444444444 | EPS15L1 AP2S1 AP2A2 AP2B1 | Signaling by Receptor Tyrosine Kinases |
| GO:0036019 | 0.0234426873659 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | endolysosome |
| KEGG:05016 | 0.0246500420483 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | Huntington disease |
| REAC:R-HSA-422475 | 0.0305735596836 | 0.444444444444 | ITSN1 AP2S1 AP2A2 AP2B1 | Axon guidance |
| REAC:R-HSA-9675108 | 0.0352407247709 | 0.444444444444 | ITSN1 AP2S1 AP2A2 AP2B1 | Nervous system development |
| GO:0099072 | 0.0359812030822 | 0.333333333333 | AP2S1 AP2A2 AP2B1 | regulation of postsynaptic membrane neurotransmitter receptor levels |
| HPA:0010012 | 0.049400955991 | 0.666666666667 | EPS15L1 NECAP2 AP2A2 AP2B1 ITSN1 AAGAB | adipose tissue; adipocytes[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| AP2A2 | AP2B1 | 1.0 | 0.336153846154 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| AP2B1 | AP2S1 | 1.0 | 0.7 |
structurally_consistent (O95782)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| AP2A2 | AP2S1 | 1.0 | 0.282 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| CCDC32 | AP2S1 | 1.0 | 0.13 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AP2B1 | NECAP2 | 1.0 | 0.09 |
mutually_exclusive (Q96CW1)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| EPS15L1 | AP2S1 | 0.999 | 0.222 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| AP2A2 | NECAP2 | 0.999 | 0.138416666667 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| ITSN1 | AP2S1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | ||
| CCDC32 | AAGAB | 0.999 | 0.11 |
mutually_exclusive (P53680)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AP2B1 | ITSN1 | 0.999 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | ||
| NECAP2 | AP2S1 | 0.999 | 0.076 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| AP2A2 | AAGAB | 0.999 | 0.1305 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| AP2A2 | EPS15L1 | 0.999 | 0.313555555556 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| AP2B1 | EPS15L1 | 0.999 | 0.446 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| AAGAB | AP2S1 | 0.998 | 0.058 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| EPS15L1 | ITSN1 | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | ||
| AP2A2 | CCDC32 | 0.998 | 0.13 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ITSN2 | EPS15L1 | 0.997 | 0.118 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| ITSN2 | ITSN1 | 0.985 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| ITSN2 | AP2S1 | 0.982 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | |
| AP2B1 | AAGAB | 0.981 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| AP2A2 | ITSN1 | 0.976 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| AP2B1 | CCDC32 | 0.974 | 0.06 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| AP2A2 | ITSN2 | 0.963 | 0.36 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| ITSN2 | AP2B1 | 0.957 | 0.082 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| NECAP2 | EPS15L1 | 0.927 | 0.096 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | |
| NECAP2 | ITSN1 | 0.913 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | ||
| AAGAB | ITSN1 | 0.656 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CCDC32 | ITSN1 | 0.617 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CCDC32 | EPS15L1 | 0.475 | 0.202 | bioplex_WMM bioplex3_WMM fraction | |
| AAGAB | EPS15L1 | 0.415 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only | |
| AAGAB | NECAP2 | 0.18 | 0.03 |
mutually_exclusive (P53680)
|
bioplex_WMM bioplex3_WMM WMM_only |
| CCDC32 | NECAP2 | 0.172 | 0.086 |
mutually_exclusive (P53680)
|
bioplex_WMM bioplex3_WMM WMM_only |
| ITSN2 | NECAP2 | 0.029 | 0.07 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| ITSN2 | CCDC32 | 0.024 | 0.05 | bioplex_WMM WMM_only | |
| ITSN2 | AAGAB | 0.02 | 0.042 | bioplex_WMM WMM_only |
Related Complexes