hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00441.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RPP40 | Ribonuclease P protein subunit p40 (RNaseP protein p40) (RNase P subunit 1) | 5 | UniProt NCBI |
| IBTK | Inhibitor of Bruton tyrosine kinase (IBtk) | 5 | UniProt NCBI |
| RPP14 | Ribonuclease P protein subunit p14 | 5 | UniProt NCBI |
| POP7 | Ribonuclease P protein subunit p20 (RNaseP protein p20) (Ribonucleases P/MRP protein subunit POP7 homolog) (hPOP7) | 5 | UniProt NCBI |
| RPP21 | Ribonuclease P protein subunit p21 (RNaseP protein p21) (Ribonuclease P/MRP 21 kDa subunit) (Ribonucleoprotein V) | 5 | UniProt NCBI |
| RPP38 | Ribonuclease P protein subunit p38 (RNaseP protein p38) | 5 | UniProt NCBI |
| C18orf21 | UPF0711 protein C18orf21 (HBV X-transactivated gene 13 protein) (HBV XAg-transactivated protein 13) | 2 | UniProt NCBI |
| POP4 | Ribonuclease P protein subunit p29 (hPOP4) | 5 | UniProt NCBI |
| RPP25L | Ribonuclease P protein subunit p25-like protein (RNase P protein subunit-like p25) (Rpp25-like protein) | 4 | UniProt NCBI |
| RPP25 | Ribonuclease P protein subunit p25 (RNase P protein subunit p25) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:123 | 3.72280841952e-20 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | Rnase/Mrp complex |
| GO:0001682 | 5.61641098591e-20 | 0.8 | RPP21 RPP25L RPP38 POP7 RPP14 RPP25 POP4 RPP40 | tRNA 5'-leader removal |
| GO:0099116 | 2.80752175065e-19 | 0.8 | RPP21 RPP25L RPP38 POP7 RPP14 RPP25 POP4 RPP40 | tRNA 5'-end processing |
| GO:0034471 | 5.49259104648e-18 | 0.8 | RPP21 RPP25L RPP38 POP7 RPP14 RPP25 POP4 RPP40 | ncRNA 5'-end processing |
| GO:0000966 | 8.87156643036e-18 | 0.8 | RPP21 RPP25L RPP38 POP7 RPP14 RPP25 POP4 RPP40 | RNA 5'-end processing |
| GO:0033204 | 2.55012376737e-17 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | ribonuclease P RNA binding |
| GO:0030681 | 2.55012376737e-17 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | multimeric ribonuclease P complex |
| GO:0004526 | 7.01157996122e-17 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | ribonuclease P activity |
| GO:1902555 | 3.43506450984e-16 | 0.8 | RPP21 RPP25L RPP38 POP7 RPP14 RPP25 POP4 RPP40 | endoribonuclease complex |
| GO:0030677 | 3.64471100416e-16 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | ribonuclease P complex |
| GO:0004549 | 7.28811167197e-16 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | tRNA-specific ribonuclease activity |
| GO:1905348 | 1.02434361033e-15 | 0.8 | RPP21 RPP25L RPP38 POP7 RPP14 RPP25 POP4 RPP40 | endonuclease complex |
| GO:0016891 | 1.39387668136e-13 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | RNA endonuclease activity, producing 5'-phosphomonoesters |
| REAC:R-HSA-6784531 | 2.06649229999e-13 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | tRNA processing in the nucleus |
| GO:0016893 | 9.04106461563e-13 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters |
| REAC:R-HSA-72306 | 1.5040161569e-11 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | tRNA processing |
| GO:0008033 | 2.20601494886e-11 | 0.8 | RPP21 RPP25L RPP38 POP7 RPP14 RPP25 POP4 RPP40 | tRNA processing |
| GO:0004521 | 4.27763906098e-11 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | RNA endonuclease activity |
| GO:0000172 | 1.26961271201e-10 | 0.5 | POP4 RPP25L RPP25 RPP40 POP7 | ribonuclease MRP complex |
| KEGG:03008 | 1.31045021989e-10 | 0.6 | RPP25L RPP25 RPP38 POP7 POP4 RPP40 | Ribosome biogenesis in eukaryotes |
| GO:0006399 | 9.11288508459e-10 | 0.8 | RPP21 RPP25L RPP38 POP7 RPP14 RPP25 POP4 RPP40 | tRNA metabolic process |
| GO:0004519 | 1.33026316603e-09 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | endonuclease activity |
| GO:0004540 | 3.85988683045e-09 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | RNA nuclease activity |
| GO:0140101 | 6.2201246689e-09 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | catalytic activity, acting on a tRNA |
| GO:0005732 | 5.94654868871e-08 | 0.5 | POP4 RPP25L RPP25 RPP40 POP7 | sno(s)RNA-containing ribonucleoprotein complex |
| GO:0004518 | 9.64362272977e-08 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | nuclease activity |
| GO:0034470 | 2.20732976441e-07 | 0.8 | RPP21 RPP25L RPP38 POP7 RPP14 RPP25 POP4 RPP40 | ncRNA processing |
| GO:0034660 | 4.69238663536e-06 | 0.8 | RPP21 RPP25L RPP38 POP7 RPP14 RPP25 POP4 RPP40 | ncRNA metabolic process |
| GO:0140098 | 1.17380829979e-05 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | catalytic activity, acting on RNA |
| REAC:R-HSA-8953854 | 1.22272500074e-05 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | Metabolism of RNA |
| GO:1990904 | 1.4492580164e-05 | 0.8 | RPP21 RPP25L RPP38 POP7 RPP14 RPP25 POP4 RPP40 | ribonucleoprotein complex |
| REAC:R-HSA-6791226 | 1.55224706415e-05 | 0.5 | RPP14 RPP25 RPP40 RPP38 RPP21 | Major pathway of rRNA processing in the nucleolus and cytosol |
| REAC:R-HSA-8868773 | 2.03426305201e-05 | 0.5 | RPP14 RPP25 RPP40 RPP38 RPP21 | rRNA processing in the nucleus and cytosol |
| REAC:R-HSA-72312 | 2.62844662368e-05 | 0.5 | RPP14 RPP25 RPP40 RPP38 RPP21 | rRNA processing |
| GO:0006396 | 0.000113767423691 | 0.8 | RPP21 RPP25L RPP38 POP7 RPP14 RPP25 POP4 RPP40 | RNA processing |
| GO:0140535 | 0.000198990526838 | 0.8 | RPP21 RPP25L RPP38 POP7 RPP14 RPP25 POP4 RPP40 | intracellular protein-containing complex |
| GO:0140640 | 0.000265566854748 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | catalytic activity, acting on a nucleic acid |
| GO:0016788 | 0.000699829966531 | 0.7 | RPP21 RPP25 RPP38 POP7 RPP14 POP4 RPP40 | hydrolase activity, acting on ester bonds |
| GO:0003723 | 0.013125327025 | 0.8 | RPP21 RPP25L RPP38 POP7 RPP14 RPP25 POP4 RPP40 | RNA binding |
| GO:1902494 | 0.0260248958425 | 0.8 | RPP21 RPP25L RPP38 POP7 RPP14 RPP25 POP4 RPP40 | catalytic complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RPP38 | RPP25L | 1.0 | 0.182 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| POP4 | RPP25L | 1.0 | 0.562 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| POP7 | POP4 | 1.0 | 0.192 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| POP7 | RPP25L | 1.0 | 0.288 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only |
| RPP40 | C18orf21 | 1.0 | 0.114 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| IBTK | RPP25L | 1.0 | 0.058 | hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| RPP38 | C18orf21 | 1.0 | 0.22 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| POP7 | C18orf21 | 1.0 | 0.134 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| POP4 | RPP25 | 1.0 | 0.204 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RPP21 | RPP38 | 1.0 | 0.16 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| POP7 | RPP21 | 1.0 | 0.194 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RPP14 | C18orf21 | 0.999 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RPP40 | POP4 | 0.999 | 0.512 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| RPP38 | RPP25 | 0.999 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| POP7 | RPP25 | 0.999 | 0.132 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RPP40 | RPP21 | 0.999 | 0.186 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RPP21 | RPP25L | 0.999 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| C18orf21 | RPP25L | 0.999 | 0.36 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RPP40 | RPP25 | 0.999 | 0.05 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RPP21 | POP4 | 0.999 | 0.14 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RPP14 | RPP21 | 0.999 | 0.178 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RPP40 | RPP14 | 0.999 | 0.756 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| POP7 | RPP38 | 0.999 | 0.148 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| RPP21 | RPP25 | 0.999 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RPP14 | RPP38 | 0.999 | 0.578 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RPP14 | POP7 | 0.999 | 0.396 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| RPP14 | POP4 | 0.999 | 0.31 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RPP38 | POP4 | 0.999 | 0.646 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| C18orf21 | RPP25 | 0.999 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RPP14 | RPP25 | 0.999 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RPP14 | RPP25L | 0.999 | 0.454 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| RPP40 | RPP25L | 0.999 | 0.354 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| RPP40 | POP7 | 0.998 | 0.164 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| C18orf21 | POP4 | 0.998 | 0.206 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| IBTK | POP7 | 0.998 | 0.066 | hein_WMM youn () bioplex3_HEK293 bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| RPP40 | RPP38 | 0.986 | 0.358 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| RPP25L | RPP25 | 0.977 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only |
| RPP21 | C18orf21 | 0.822 | 0.224 | bioplex_WMM bioplex3_WMM WMM_only |
| IBTK | C18orf21 | 0.82 | 0.052 | bioplex3_WMM WMM_only |
| IBTK | RPP14 | 0.726 | 0.064 | bioplex3_WMM youn_WMM WMM_only |
| IBTK | RPP38 | 0.393 | 0.042 | hein_WMM bioplex3_WMM youn_WMM WMM_only |
| IBTK | RPP25 | 0.334 | 0.084 | bioplex3_WMM WMM_only |
| IBTK | POP4 | 0.247 | 0.12 | hein_WMM bioplex3_WMM youn_WMM WMM_only |
| RPP40 | IBTK | 0.243 | 0.038 | bioplex3_WMM youn_WMM WMM_only |
Related Complexes