hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00443.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PITPNM1 | Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) | 5 | UniProt NCBI |
| TRIP4 | Activating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TR-interacting protein 4) (TRIP-4) | 5 | UniProt NCBI |
| ASCC3 | Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200) | 5 | UniProt NCBI |
| ASCC2 | Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100) | 5 | UniProt NCBI |
| ALKBH3 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (EC 1.14.11.33) (EC 1.14.11.54) (Alkylated DNA repair protein alkB homolog 3) (hABH3) (DEPC-1) (Prostate cancer antigen 1) | 5 | UniProt NCBI |
| ASCC1 | Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1377 | 9.60315000334e-13 | 0.666666666667 | ASCC3 TRIP4 ASCC1 ASCC2 | hASC-1 complex |
| REAC:R-HSA-112126 | 1.45106421006e-12 | 0.666666666667 | ASCC3 ASCC2 ASCC1 ALKBH3 | ALKBH3 mediated reversal of alkylation damage |
| REAC:R-HSA-73943 | 5.07705636973e-11 | 0.666666666667 | ASCC3 ASCC2 ASCC1 ALKBH3 | Reversal of alkylation damage by DNA dioxygenases |
| REAC:R-HSA-73942 | 5.07705636973e-11 | 0.666666666667 | ASCC3 ASCC2 ASCC1 ALKBH3 | DNA Damage Reversal |
| GO:0006307 | 2.76161616937e-08 | 0.666666666667 | ASCC3 ASCC2 ASCC1 ALKBH3 | DNA dealkylation involved in DNA repair |
| GO:0099053 | 1.92240082153e-06 | 0.5 | ASCC3 TRIP4 ASCC2 | activating signal cointegrator 1 complex |
| GO:0035510 | 4.98134660408e-06 | 0.666666666667 | ASCC3 ASCC2 ASCC1 ALKBH3 | DNA dealkylation |
| GO:1990116 | 3.84302573496e-05 | 0.5 | ASCC3 TRIP4 ASCC2 | ribosome-associated ubiquitin-dependent protein catabolic process |
| GO:0006304 | 0.000155002771391 | 0.666666666667 | ASCC3 ASCC2 ASCC1 ALKBH3 | DNA modification |
| REAC:R-HSA-73894 | 0.000502730176626 | 0.666666666667 | ASCC3 ASCC2 ASCC1 ALKBH3 | DNA Repair |
| GO:1990391 | 0.00218580514948 | 0.5 | ASCC3 ASCC2 ASCC1 | DNA repair complex |
| GO:0072344 | 0.00498056162807 | 0.5 | ASCC3 TRIP4 ASCC2 | rescue of stalled ribosome |
| GO:0032790 | 0.0104402436969 | 0.5 | ASCC3 TRIP4 ASCC2 | ribosome disassembly |
| HP:0005855 | 0.0146541203169 | 0.333333333333 | ASCC1 TRIP4 | Multiple prenatal fractures |
| HP:0003447 | 0.0164828756284 | 0.333333333333 | ASCC1 TRIP4 | Axonal loss |
| HPA:0470683 | 0.0232678479942 | 0.666666666667 | ASCC3 TRIP4 ASCC1 ASCC2 | skin 2; epidermal cells[High] |
| GO:0032508 | 0.0271028431288 | 0.5 | ASCC3 ASCC2 ASCC1 | DNA duplex unwinding |
| GO:0032392 | 0.0446883661999 | 0.5 | ASCC3 ASCC2 ASCC1 | DNA geometric change |
| GO:0006414 | 0.0473097913612 | 0.5 | ASCC3 TRIP4 ASCC2 | translational elongation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TRIP4 | ASCC2 | 1.0 | 0.276 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction |
| ASCC3 | ASCC2 | 1.0 | 0.826 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction |
| TRIP4 | ASCC1 | 1.0 | 0.248 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| TRIP4 | ASCC3 | 0.999 | 0.366 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| ASCC3 | ASCC1 | 0.999 | 0.516 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| ASCC2 | ASCC1 | 0.999 | 0.18 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| PITPNM1 | ASCC1 | 0.997 | 0.052 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ALKBH3 | ASCC1 | 0.992 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ASCC2 | ALKBH3 | 0.99 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TRIP4 | ALKBH3 | 0.984 | 0.22 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ASCC3 | ALKBH3 | 0.868 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes