hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00460.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RNASEH2A | Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Aicardi-Goutieres syndrome 4 protein) (AGS4) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A) | 5 | UniProt NCBI |
| RNASEH2B | Ribonuclease H2 subunit B (RNase H2 subunit B) (Aicardi-Goutieres syndrome 2 protein) (AGS2) (Deleted in lymphocytic leukemia 8) (Ribonuclease HI subunit B) | 5 | UniProt NCBI |
| RNASEH2C | Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4705 | 2.82158830257e-08 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Pathways of nucleic acid metabolism and innate immune sensing |
| HP:0009709 | 4.84929936962e-08 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Increased CSF interferon alpha |
| HP:0009704 | 4.84929936962e-08 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Chronic CSF lymphocytosis |
| HP:0009710 | 7.27394905443e-08 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Chilblains |
| GO:0032299 | 9.61200410764e-08 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | ribonuclease H2 complex |
| HP:0004809 | 1.42881142141e-07 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Neonatal alloimmune thrombocytopenia |
| HP:0040140 | 1.42881142141e-07 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Degeneration of the striatum |
| HP:0007052 | 2.47660646377e-07 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Multifocal cerebral white matter abnormalities |
| HP:0005550 | 2.47660646377e-07 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Chronic lymphatic leukemia |
| HP:0007076 | 3.15204459025e-07 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Extrapyramidal muscular rigidity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RNASEH2C | RNASEH2A | 0.999 | 0.72 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 fraction |
| RNASEH2C | RNASEH2B | 0.999 | 0.366 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 fraction |
| RNASEH2A | RNASEH2B | 0.996 | 0.652 | hein_WMM bioplex3_WMM hein () fraction |
Related Complexes
| Genename | Complexes |
|---|---|
| RNASEH2C | huMAP3_00460.1 huMAP3_05575.1 |
| RNASEH2A | huMAP3_00460.1 huMAP3_01583.1 huMAP3_05575.1 huMAP3_09404.1 huMAP3_10079.1 |
| RNASEH2B | huMAP3_00460.1 huMAP3_05575.1 |