hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00460.1
Complex Portal: CPX-745
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RNASEH2C | Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C) | 5 | UniProt NCBI |
| RNASEH2A | Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Aicardi-Goutieres syndrome 4 protein) (AGS4) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A) | 5 | UniProt NCBI |
| RNASEH2B | Ribonuclease H2 subunit B (RNase H2 subunit B) (Aicardi-Goutieres syndrome 2 protein) (AGS2) (Deleted in lymphocytic leukemia 8) (Ribonuclease HI subunit B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4705 | 2.82158830257e-08 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Pathways of nucleic acid metabolism and innate immune sensing |
| HP:0009709 | 4.84929936962e-08 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Increased CSF interferon alpha |
| HP:0009704 | 4.84929936962e-08 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Chronic CSF lymphocytosis |
| HP:0009710 | 7.27394905443e-08 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Chilblains |
| GO:0032299 | 9.61200410764e-08 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | ribonuclease H2 complex |
| HP:0004809 | 1.42881142141e-07 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Neonatal alloimmune thrombocytopenia |
| HP:0040140 | 1.42881142141e-07 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Degeneration of the striatum |
| HP:0007052 | 2.47660646377e-07 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Multifocal cerebral white matter abnormalities |
| HP:0005550 | 2.47660646377e-07 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Chronic lymphatic leukemia |
| HP:0007076 | 3.15204459025e-07 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Extrapyramidal muscular rigidity |
| HP:0011834 | 3.15204459025e-07 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Moyamoya phenomenon |
| KEGG:03030 | 3.72987550699e-07 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | DNA replication |
| HP:0001955 | 3.94005573782e-07 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Unexplained fevers |
| HP:0200149 | 5.88843494883e-07 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | CSF lymphocytic pleiocytosis |
| HP:0004963 | 7.06612193859e-07 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Calcification of the aorta |
| HP:0030356 | 7.06612193859e-07 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Increased circulating interferon-gamma concentration |
| HP:0030038 | 9.87178800245e-07 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Enchondroma |
| HP:0012229 | 1.15170860029e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | CSF pleocytosis |
| HP:0005558 | 1.15170860029e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Chronic leukemia |
| HP:0030355 | 1.33355732665e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal circulating interferon-gamma concentration |
| HP:0030354 | 1.33355732665e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal circulating interferon concentration |
| HP:0003207 | 1.75267534359e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Arterial calcification |
| HP:0012490 | 1.75267534359e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Panniculitis |
| HP:0004934 | 2.53289297431e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Vascular calcification |
| HP:0002132 | 3.16416783868e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Porencephalic cyst |
| HP:0011112 | 3.89242869044e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormality of serum cytokine level |
| HP:0001063 | 3.89242869044e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Acrocyanosis |
| HP:0100614 | 4.29509372738e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Myositis |
| HP:0011915 | 4.29509372738e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Cardiovascular calcification |
| HP:0011111 | 4.29509372738e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormality of immune serum protein physiology |
| HP:0000625 | 4.29509372738e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Eyelid coloboma |
| HP:0002139 | 4.72460310012e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Arrhinencephaly |
| HP:0034033 | 4.72460310012e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Peripheral cyanosis |
| HP:0011226 | 7.91388338196e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Aplasia/Hypoplasia of the eyelid |
| HP:0010994 | 8.55554960212e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal corpus striatum morphology |
| HP:0030880 | 9.2309877286e-06 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Raynaud phenomenon |
| HP:0002371 | 1.59541949261e-05 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Loss of speech |
| HP:0007108 | 2.02856583987e-05 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Demyelinating peripheral neuropathy |
| HP:0002313 | 2.14789324222e-05 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Spastic paraparesis |
| HP:0006579 | 2.53375892063e-05 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Prolonged neonatal jaundice |
| HP:0002828 | 3.1165407913e-05 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Multiple joint contractures |
| HP:0000965 | 3.96257034203e-05 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Cutis marmorata |
| HP:0100578 | 4.33977655729e-05 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Lipoatrophy |
| HP:0001087 | 4.33977655729e-05 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Developmental glaucoma |
| HP:0009145 | 4.74019013381e-05 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal cerebral artery morphology |
| HP:0002385 | 5.61341039886e-05 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Paraparesis |
| HP:0002180 | 5.61341039886e-05 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Neurodegeneration |
| HP:0003552 | 5.61341039886e-05 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Muscle stiffness |
| HP:0000444 | 6.84781687233e-05 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Convex nasal ridge |
| HP:0000961 | 9.83403274307e-05 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Cyanosis |
| HP:0002415 | 0.000116074907982 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Leukodystrophy |
| HP:0002187 | 0.000123726409631 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Intellectual disability, profound |
| HP:0001609 | 0.000127675124832 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Hoarse voice |
| HP:0010622 | 0.000127675124832 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Neoplasm of the skeletal system |
| HP:0002510 | 0.000167058363283 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Spastic tetraplegia |
| HP:0009125 | 0.000197366484344 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Lipodystrophy |
| HP:0001640 | 0.000219482753254 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Cardiomegaly |
| HP:0002514 | 0.000231134926883 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Cerebral calcification |
| HP:0034221 | 0.000237112554302 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal temporal lobe morphology |
| HP:0025454 | 0.000331922418602 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal CSF metabolite concentration |
| HP:0001357 | 0.000347240142986 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Plagiocephaly |
| HP:0001433 | 0.000347240142986 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Hepatosplenomegaly |
| GO:0006298 | 0.000351222630093 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | mismatch repair |
| HP:0004942 | 0.000379274961 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Aortic aneurysm |
| HP:0100021 | 0.000439970004235 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Cerebral palsy |
| HP:0025323 | 0.000458428515907 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal arterial physiology |
| HP:0000958 | 0.000477396204013 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Dry skin |
| HP:0001909 | 0.000516886819808 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Leukemia |
| HP:0002134 | 0.00064829936894 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal basal ganglia morphology |
| HP:0000952 | 0.000773463249455 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Jaundice |
| HP:0001369 | 0.000800286802539 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Arthritis |
| HP:0002063 | 0.000813928054855 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Rigidity |
| HP:0002617 | 0.000870043108025 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Vascular dilatation |
| HP:0010551 | 0.00100560613785 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Paraplegia/paraparesis |
| HP:0010766 | 0.00100560613785 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Ectopic calcification |
| HP:0004374 | 0.00112027388307 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Hemiplegia/hemiparesis |
| HP:0002061 | 0.00117197174408 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Lower limb spasticity |
| HP:0009124 | 0.00137511062657 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal adipose tissue morphology |
| HP:0011119 | 0.00139466196249 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal nasal dorsum morphology |
| HP:0002960 | 0.00153673431077 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Autoimmunity |
| HP:0000054 | 0.00162209063914 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Micropenis |
| HP:0001396 | 0.00173315691363 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Cholestasis |
| HP:0000737 | 0.00192121967075 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Irritability |
| HP:0001639 | 0.00230958793402 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Hypertrophic cardiomyopathy |
| HP:0002355 | 0.00250745147155 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Difficulty walking |
| HP:0004377 | 0.002595597013 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Hematological neoplasm |
| HP:0001005 | 0.00265549365373 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Dermatological manifestations of systemic disorders |
| HP:0002071 | 0.00268578445587 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormality of extrapyramidal motor function |
| HP:0030163 | 0.00303431918859 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal vascular physiology |
| HP:0008936 | 0.00323654449772 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Axial hypotonia |
| HP:0002315 | 0.00327109835356 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Headache |
| HP:0007700 | 0.00330589727222 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Ocular anterior segment dysgenesis |
| HP:0100659 | 0.0038192986581 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal cerebral vascular morphology |
| HP:0000501 | 0.00429952304279 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Glaucoma |
| HP:0002910 | 0.00446811413105 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Elevated hepatic transaminase |
| HP:0000821 | 0.0046410557336 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Hypothyroidism |
| HP:0004297 | 0.00490874658422 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormality of the biliary system |
| HP:0002926 | 0.00528141177699 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormality of thyroid physiology |
| HP:0001679 | 0.00562257211089 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal aortic morphology |
| HP:0001945 | 0.00572267550502 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Fever |
| HP:0008736 | 0.00587504741878 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Hypoplasia of penis |
| HP:0034353 | 0.00587504741878 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Appendicular spasticity |
| HP:0001873 | 0.00613496986499 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Thrombocytopenia |
| HP:0011400 | 0.00678981578808 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal CNS myelination |
| HP:0002376 | 0.00707586816438 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Developmental regression |
| HP:0011873 | 0.00767185138664 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal platelet count |
| HP:0011875 | 0.00785695607115 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal platelet morphology |
| HP:0007256 | 0.00804501449854 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal pyramidal sign |
| HP:0000819 | 0.00817203929769 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Diabetes mellitus |
| HP:0001744 | 0.00817203929769 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Splenomegaly |
| HP:0001608 | 0.00823605004937 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormality of the voice |
| HP:0001952 | 0.0086935087054 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Glucose intolerance |
| HP:0011123 | 0.00889463686054 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Inflammatory abnormality of the skin |
| HP:0001872 | 0.00923670297429 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormality of thrombocytes |
| HP:0009830 | 0.0100198821414 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Peripheral neuropathy |
| HP:0000050 | 0.0100931983522 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Hypoplastic male external genitalia |
| HP:0002079 | 0.0100931983522 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Hypoplasia of the corpus callosum |
| HP:0004302 | 0.0110790903562 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Functional motor deficit |
| HP:0003241 | 0.0120443052941 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | External genital hypoplasia |
| HP:0010549 | 0.0121271789544 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Weakness due to upper motor neuron dysfunction |
| HP:0000820 | 0.0122104318992 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormality of the thyroid gland |
| HP:0004370 | 0.0123780791059 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormality of temperature regulation |
| HP:0011122 | 0.0130640125018 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormality of skin physiology |
| HP:0011004 | 0.0134162829269 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal systemic arterial morphology |
| HP:0001332 | 0.0135053290525 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Dystonia |
| HP:0025408 | 0.015176225292 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal spleen morphology |
| HP:0001638 | 0.0165671073988 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Cardiomyopathy |
| HP:0001743 | 0.0176109580557 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormality of the spleen |
| HP:0011276 | 0.0177176911348 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Vascular skin abnormality |
| HP:0001637 | 0.0190323050199 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal myocardium morphology |
| HP:0010987 | 0.0204103893061 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal cellular immune system morphology |
| HP:0012379 | 0.0204103893061 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal circulating enzyme concentration or activity |
| HP:0001881 | 0.0204103893061 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal leukocyte morphology |
| HP:0002921 | 0.0208841138977 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal cerebrospinal fluid morphology |
| HP:0001337 | 0.0211237004606 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Tremor |
| HP:0032251 | 0.0221003701364 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal immune system morphology |
| HP:0012447 | 0.0229792632158 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal myelination |
| HP:0002240 | 0.0236211069549 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Hepatomegaly |
| HP:0034684 | 0.0263079825031 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal enzyme concentration or activity |
| HP:0100851 | 0.0272944330425 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal emotion |
| HP:0000036 | 0.0278690351843 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal penis morphology |
| HP:0011014 | 0.0281593358932 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal glucose homeostasis |
| HP:0030962 | 0.0337349996922 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal morphology of the great vessels |
| HP:0100763 | 0.0347303971889 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormality of the lymphatic system |
| HP:0003271 | 0.0348981768855 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Visceromegaly |
| HP:0000508 | 0.0405566996236 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Ptosis |
| HP:0000253 | 0.0429026841472 | 0.666666666667 | RNASEH2C RNASEH2A | Progressive microcephaly |
| HP:0002119 | 0.043601990352 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Ventriculomegaly |
| HP:0007370 | 0.0449808704429 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Aplasia/Hypoplasia of the corpus callosum |
| HP:0001438 | 0.0451801948319 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal abdomen morphology |
| HP:0001371 | 0.0470006772358 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Flexion contracture |
| HP:0012444 | 0.0474117601369 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Brain atrophy |
| HP:0002538 | 0.0478252330498 | 1.0 | RNASEH2C RNASEH2B RNASEH2A | Abnormal cerebral cortex morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RNASEH2C | RNASEH2A | 0.999 | 0.72 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 fraction | |
| RNASEH2C | RNASEH2B | 0.999 | 0.366 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 fraction | |
| RNASEH2A | RNASEH2B | 0.996 | 0.652 | hein_WMM bioplex3_WMM hein () fraction |
Related Complexes
| Genename | Complexes |
|---|---|
| RNASEH2C | huMAP3_00460.1 huMAP3_05575.1 |
| RNASEH2A | huMAP3_00460.1 huMAP3_01583.1 huMAP3_05575.1 huMAP3_09404.1 huMAP3_10079.1 |
| RNASEH2B | huMAP3_00460.1 huMAP3_05575.1 |