hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00471.1
Complex Portal: CPX-12876
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UNC119 | Protein unc-119 homolog A (Retinal protein 4) (hRG4) | 5 | UniProt NCBI |
| PDE9A | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35) | 5 | UniProt NCBI |
| PRKG2 | cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-418457 | 0.000449812862905 | 0.666666666667 | PRKG2 PDE9A | cGMP effects |
| REAC:R-HSA-392154 | 0.000926675585137 | 0.666666666667 | PRKG2 PDE9A | Nitric oxide stimulates guanylate cyclase |
| REAC:R-HSA-418346 | 0.017372320015 | 0.666666666667 | PRKG2 PDE9A | Platelet homeostasis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PDE9A | UNC119 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| UNC119 | PRKG2 | 0.966 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | ||
| PDE9A | PRKG2 | 0.65 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
Related Complexes