hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00487.1
Complex Portal: CPX-18390
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LIN52 | Protein lin-52 homolog | 3 | UniProt NCBI |
| RBL2 | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | 5 | UniProt NCBI |
| LIN37 | Protein lin-37 homolog (Antolefinin) | 5 | UniProt NCBI |
| LIN54 | Protein lin-54 homolog (CXC domain-containing protein 1) | 5 | UniProt NCBI |
| MYBL2 | Myb-related protein B (B-Myb) (Myb-like protein 2) | 5 | UniProt NCBI |
| RBL1 | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | 5 | UniProt NCBI |
| MYBL1 | Myb-related protein A (A-Myb) (Myb-like protein 1) | 5 | UniProt NCBI |
| LIN9 | Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein) | 5 | UniProt NCBI |
| TESMIN | Tesmin (Metallothionein-like 5, testis-specific) (Testis-specific metallothionein-like protein) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1362300 | 5.96134466021e-13 | 0.833333333333 | LIN54 RBL1 RBL2 LIN9 LIN37 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| REAC:R-HSA-1362277 | 1.70056796601e-12 | 0.833333333333 | LIN54 RBL1 RBL2 LIN9 LIN37 | Transcription of E2F targets under negative control by DREAM complex |
| CORUM:5589 | 4.80104919782e-12 | 0.666666666667 | LIN54 LIN37 LIN9 RBL1 | LINC complex, S-phase |
| REAC:R-HSA-1538133 | 1.3049985846e-11 | 0.833333333333 | LIN54 RBL1 RBL2 LIN9 LIN37 | G0 and Early G1 |
| CORUM:5596 | 1.44015702719e-11 | 0.666666666667 | LIN54 RBL2 LIN9 LIN37 | LINC complex, quiescent cells |
| REAC:R-HSA-69205 | 1.60149771012e-11 | 0.833333333333 | LIN54 RBL1 RBL2 LIN9 LIN37 | G1/S-Specific Transcription |
| WP:WP5180 | 2.44449534404e-10 | 0.833333333333 | LIN54 RBL1 RBL2 LIN9 LIN37 | DYRK1A involvement regarding cell proliferation in brain development |
| CORUM:5593 | 1.87066161015e-08 | 0.5 | LIN54 LIN37 LIN9 | LINC core complex |
| KEGG:04218 | 2.31404348768e-08 | 0.833333333333 | LIN54 RBL1 RBL2 LIN9 LIN37 | Cellular senescence |
| REAC:R-HSA-69206 | 5.64501636203e-08 | 0.833333333333 | LIN54 RBL1 RBL2 LIN9 LIN37 | G1/S Transition |
| REAC:R-HSA-453279 | 1.05210790032e-07 | 0.833333333333 | LIN54 RBL1 RBL2 LIN9 LIN37 | Mitotic G1 phase and G1/S transition |
| REAC:R-HSA-69202 | 2.51636763457e-06 | 0.666666666667 | LIN54 RBL2 LIN9 LIN37 | Cyclin E associated events during G1/S transition |
| REAC:R-HSA-69656 | 2.77535713302e-06 | 0.666666666667 | LIN54 RBL2 LIN9 LIN37 | Cyclin A:Cdk2-associated events at S phase entry |
| REAC:R-HSA-156711 | 3.20984225624e-06 | 0.5 | LIN54 LIN37 LIN9 | Polo-like kinase mediated events |
| REAC:R-HSA-69242 | 3.65722772768e-05 | 0.666666666667 | LIN54 RBL2 LIN9 LIN37 | S Phase |
| REAC:R-HSA-69278 | 6.34457226533e-05 | 0.833333333333 | LIN54 RBL1 RBL2 LIN9 LIN37 | Cell Cycle, Mitotic |
| REAC:R-HSA-1640170 | 0.000178011057657 | 0.833333333333 | LIN54 RBL1 RBL2 LIN9 LIN37 | Cell Cycle |
| CORUM:6444 | 0.00025612721106 | 0.333333333333 | RBL1 RBL2 | SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex |
| WP:WP53 | 0.000663806947581 | 0.333333333333 | RBL1 RBL2 | ID signaling pathway |
| CORUM:5614 | 0.00291292900525 | 0.333333333333 | RBL1 RBL2 | Emerin complex 32 |
| REAC:R-HSA-6804114 | 0.0035019037522 | 0.333333333333 | RBL1 RBL2 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
| REAC:R-HSA-69275 | 0.00760491079328 | 0.5 | LIN54 LIN37 LIN9 | G2/M Transition |
| REAC:R-HSA-453274 | 0.00784777894324 | 0.5 | LIN54 LIN37 LIN9 | Mitotic G2-G2/M phases |
| REAC:R-HSA-6791312 | 0.0253617614497 | 0.333333333333 | RBL1 RBL2 | TP53 Regulates Transcription of Cell Cycle Genes |
| REAC:R-HSA-69236 | 0.0265097243254 | 0.333333333333 | RBL1 RBL2 | G1 Phase |
| REAC:R-HSA-69231 | 0.0265097243254 | 0.333333333333 | RBL1 RBL2 | Cyclin D associated events in G1 |
| CORUM:839 | 0.0499436884912 | 0.166666666667 | LIN9 | LIN9-BMYB complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LIN37 | LIN54 | 1.0 | 0.148 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| LIN37 | LIN9 | 1.0 | 0.174 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| LIN52 | LIN9 | 1.0 | 0.198 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LIN37 | MYBL2 | 1.0 | 0.164 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| LIN54 | LIN9 | 1.0 | 0.324 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| LIN52 | LIN37 | 1.0 | 0.18 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MYBL2 | LIN9 | 1.0 | 0.248 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| MYBL1 | LIN9 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| LIN37 | MYBL1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| LIN52 | MYBL1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LIN52 | LIN54 | 0.998 | 0.21 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| LIN54 | MYBL1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| RBL2 | RBL1 | 0.996 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| LIN52 | MYBL2 | 0.99 | 0.184 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| LIN37 | TESMIN | 0.976 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LIN9 | TESMIN | 0.976 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| LIN37 | RBL1 | 0.967 | 0.16 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MYBL2 | MYBL1 | 0.967 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RBL2 | LIN37 | 0.965 | 0.08 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LIN54 | MYBL2 | 0.965 | 0.206 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| RBL1 | LIN9 | 0.962 | 0.184 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RBL2 | LIN9 | 0.96 | 0.122 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RBL1 | TESMIN | 0.633 | bioplex3_WMM WMM_only | ||
| RBL2 | TESMIN | 0.633 | bioplex3_WMM WMM_only | ||
| MYBL2 | TESMIN | 0.633 | bioplex3_WMM WMM_only | ||
| MYBL1 | TESMIN | 0.633 | bioplex3_WMM WMM_only | ||
| LIN52 | TESMIN | 0.633 | bioplex3_WMM WMM_only | ||
| LIN54 | TESMIN | 0.633 | bioplex3_WMM WMM_only | ||
| MYBL2 | RBL1 | 0.616 | 0.238 | bioplex3_WMM WMM_only | |
| RBL1 | MYBL1 | 0.616 | bioplex3_WMM WMM_only | ||
| RBL2 | MYBL2 | 0.616 | 0.12 | bioplex3_WMM WMM_only | |
| RBL2 | MYBL1 | 0.616 | bioplex3_WMM WMM_only | ||
| LIN52 | RBL1 | 0.404 | 0.108 | bioplex3_WMM WMM_only | |
| LIN52 | RBL2 | 0.404 | 0.066 | bioplex3_WMM WMM_only | |
| LIN54 | RBL1 | 0.372 | 0.206 | bioplex3_WMM WMM_only | |
| RBL2 | LIN54 | 0.36 | 0.128 | bioplex3_WMM WMM_only |
Related Complexes