hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00489.1
Complex Portal: CPX-10599
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CWC22 | Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) | 5 | UniProt NCBI |
| EPB41L2 | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | 5 | UniProt NCBI |
| NKTR | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | 5 | UniProt NCBI |
| ACIN1 | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | 5 | UniProt NCBI |
| SRSF10 | Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) | 5 | UniProt NCBI |
| TRA2B | Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) | 5 | UniProt NCBI |
| RNPS1 | RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2) | 5 | UniProt NCBI |
| VANGL1 | Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) | 5 | UniProt NCBI |
| U2AF2 | Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit) | 5 | UniProt NCBI |
| EPB41L1 | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-72163 | 1.33674719728e-05 | 0.555555555556 | CWC22 RNPS1 SRSF10 TRA2B ACIN1 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 1.58643659332e-05 | 0.555555555556 | CWC22 RNPS1 SRSF10 TRA2B ACIN1 | mRNA Splicing |
| GO:0048024 | 3.43989524199e-05 | 0.555555555556 | CWC22 RNPS1 SRSF10 TRA2B ACIN1 | regulation of mRNA splicing, via spliceosome |
| REAC:R-HSA-72203 | 6.27092099804e-05 | 0.555555555556 | CWC22 RNPS1 SRSF10 TRA2B ACIN1 | Processing of Capped Intron-Containing Pre-mRNA |
| CORUM:351 | 7.28748929384e-05 | 0.444444444444 | CWC22 RNPS1 TRA2B ACIN1 | Spliceosome |
| CORUM:760 | 8.20609246787e-05 | 0.222222222222 | ACIN1 RNPS1 | Apoptosis- and splicing-associated protein complex (ASAP-L), SAP18, RNPS1, Acinus-L |
| GO:0050684 | 0.000107075384876 | 0.555555555556 | CWC22 RNPS1 SRSF10 TRA2B ACIN1 | regulation of mRNA processing |
| GO:0043484 | 0.000790921106799 | 0.555555555556 | CWC22 RNPS1 SRSF10 TRA2B ACIN1 | regulation of RNA splicing |
| HPA:0291162 | 0.00137176523345 | 0.777777777778 | CWC22 ACIN1 EPB41L1 EPB41L2 NKTR TRA2B VANGL1 | liver; cholangiocytes[>=Medium] |
| KEGG:03040 | 0.0024982102573 | 0.333333333333 | ACIN1 TRA2B SRSF10 | Spliceosome |
| WP:WP411 | 0.00419312016767 | 0.333333333333 | SRSF10 TRA2B RNPS1 | mRNA processing |
| GO:0048025 | 0.00450341440411 | 0.333333333333 | ACIN1 RNPS1 SRSF10 | negative regulation of mRNA splicing, via spliceosome |
| REAC:R-HSA-8953854 | 0.00564646741329 | 0.555555555556 | CWC22 RNPS1 SRSF10 TRA2B ACIN1 | Metabolism of RNA |
| GO:0050686 | 0.00655807506899 | 0.333333333333 | ACIN1 RNPS1 SRSF10 | negative regulation of mRNA processing |
| GO:1903311 | 0.00669909318912 | 0.555555555556 | CWC22 RNPS1 SRSF10 TRA2B ACIN1 | regulation of mRNA metabolic process |
| GO:0033119 | 0.0106791414882 | 0.333333333333 | ACIN1 RNPS1 SRSF10 | negative regulation of RNA splicing |
| GO:0000398 | 0.011418023714 | 0.555555555556 | CWC22 RNPS1 SRSF10 TRA2B ACIN1 | mRNA splicing, via spliceosome |
| GO:0000377 | 0.011418023714 | 0.555555555556 | CWC22 RNPS1 SRSF10 TRA2B ACIN1 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000375 | 0.0122982783461 | 0.555555555556 | CWC22 RNPS1 SRSF10 TRA2B ACIN1 | RNA splicing, via transesterification reactions |
| WP:WP4148 | 0.0202568688475 | 0.222222222222 | EPB41L2 EPB41L1 | Splicing factor NOVA regulated synaptic proteins |
| GO:0006397 | 0.0358806003362 | 0.555555555556 | CWC22 RNPS1 SRSF10 TRA2B ACIN1 | mRNA processing |
| HPA:0080123 | 0.0435725850613 | 0.444444444444 | ACIN1 RNPS1 EPB41L2 TRA2B | caudate; glial cells[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EPB41L2 | EPB41L1 | 0.999 | 0.076 |
mutually_exclusive (O95865)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| CWC22 | EPB41L2 | 0.998 | 0.066 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| ACIN1 | RNPS1 | 0.998 | 0.92 |
mutually_exclusive (P61326)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| RNPS1 | TRA2B | 0.997 | 0.976 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| CWC22 | RNPS1 | 0.996 | 0.318 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction | |
| ACIN1 | NKTR | 0.996 | 0.362 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| RNPS1 | SRSF10 | 0.996 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM | ||
| U2AF2 | SRSF10 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM | ||
| U2AF2 | TRA2B | 0.994 | 0.9 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM | |
| RNPS1 | NKTR | 0.994 | 0.316 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| RNPS1 | U2AF2 | 0.993 | 0.882 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| RNPS1 | EPB41L1 | 0.989 | 0.078 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| ACIN1 | EPB41L1 | 0.983 | 0.064 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| RNPS1 | VANGL1 | 0.982 | 0.116 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| ACIN1 | U2AF2 | 0.98 | 0.73 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM | |
| EPB41L1 | VANGL1 | 0.975 | 0.102 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| SRSF10 | TRA2B | 0.975 |
mutually_exclusive (P61326)
|
bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| EPB41L2 | ACIN1 | 0.973 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| ACIN1 | SRSF10 | 0.968 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM | ||
| EPB41L2 | RNPS1 | 0.967 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| CWC22 | ACIN1 | 0.964 | 0.304 | bioplex_WMM bioplex3_WMM youn_WMM fraction treiber_WMM | |
| CWC22 | EPB41L1 | 0.962 | 0.038 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| NKTR | TRA2B | 0.898 | 0.254 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| NKTR | SRSF10 | 0.89 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | ||
| U2AF2 | VANGL1 | 0.817 | 0.156 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| ACIN1 | TRA2B | 0.77 | 0.814 |
mutually_exclusive (P61326)
|
bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| CWC22 | SRSF10 | 0.623 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM | ||
| CWC22 | TRA2B | 0.593 | 0.534 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CWC22 | NKTR | 0.508 | 0.206 | bioplex_WMM bioplex3_WMM WMM_only | |
| EPB41L2 | VANGL1 | 0.463 | 0.222 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| U2AF2 | NKTR | 0.459 | 0.31 | bioplex_WMM bioplex3_WMM WMM_only | |
| CWC22 | U2AF2 | 0.428 | 0.334 | bioplex_WMM bioplex3_WMM youn_WMM fraction treiber_WMM | |
| ACIN1 | VANGL1 | 0.369 | 0.198 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| CWC22 | VANGL1 | 0.294 | 0.094 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NKTR | VANGL1 | 0.271 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only | |
| EPB41L1 | SRSF10 | 0.183 | bioplex_WMM bioplex3_WMM WMM_only | ||
| EPB41L2 | TRA2B | 0.084 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| EPB41L2 | SRSF10 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | ||
| SRSF10 | VANGL1 | 0.072 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| EPB41L1 | NKTR | 0.049 | 0.106 | bioplex3_WMM WMM_only | |
| TRA2B | VANGL1 | 0.044 | 0.102 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| EPB41L1 | TRA2B | 0.024 | 0.114 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| EPB41L2 | NKTR | 0.022 | 0.054 | bioplex3_WMM WMM_only | |
| EPB41L1 | U2AF2 | 0.004 | 0.198727272727 | bioplex3_WMM gupta_WMM WMM_only | |
| EPB41L2 | U2AF2 | 0.002 | 0.168 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
Related Complexes