hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_00489.1

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
CWC22	Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb)	5	UniProt NCBI
EPB41L2	Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G)	5	UniProt NCBI
NKTR	NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase)	5	UniProt NCBI
ACIN1	Apoptotic chromatin condensation inducer in the nucleus (Acinus)	5	UniProt NCBI
SRSF10	Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)	5	UniProt NCBI
TRA2B	Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)	5	UniProt NCBI
RNPS1	RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2)	5	UniProt NCBI
VANGL1	Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1)	5	UniProt NCBI
U2AF2	Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)	5	UniProt NCBI
EPB41L1	Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-72163	1.33674719728e-05	0.555555555556	TRA2B ACIN1 CWC22 RNPS1 SRSF10	mRNA Splicing - Major Pathway
REAC:R-HSA-72172	1.58643659332e-05	0.555555555556	TRA2B ACIN1 CWC22 RNPS1 SRSF10	mRNA Splicing
GO:0048024	3.43989524199e-05	0.555555555556	TRA2B ACIN1 CWC22 RNPS1 SRSF10	regulation of mRNA splicing, via spliceosome
REAC:R-HSA-72203	6.27092099804e-05	0.555555555556	TRA2B ACIN1 CWC22 RNPS1 SRSF10	Processing of Capped Intron-Containing Pre-mRNA
CORUM:351	7.28748929384e-05	0.444444444444	ACIN1 CWC22 RNPS1 TRA2B	Spliceosome
CORUM:760	8.20609246787e-05	0.222222222222	ACIN1 RNPS1	Apoptosis- and splicing-associated protein complex (ASAP-L), SAP18, RNPS1, Acinus-L
GO:0050684	0.000107075384876	0.555555555556	TRA2B ACIN1 CWC22 RNPS1 SRSF10	regulation of mRNA processing
GO:0043484	0.000790921106799	0.555555555556	TRA2B ACIN1 CWC22 RNPS1 SRSF10	regulation of RNA splicing
HPA:0291162	0.00137176523345	0.777777777778	CWC22 EPB41L1 VANGL1 TRA2B NKTR ACIN1 EPB41L2	liver; cholangiocytes[>=Medium]
KEGG:03040	0.0024982102573	0.333333333333	ACIN1 SRSF10 TRA2B	Spliceosome
WP:WP411	0.00419312016767	0.333333333333	TRA2B SRSF10 RNPS1	mRNA processing
GO:0048025	0.00450341440411	0.333333333333	ACIN1 SRSF10 RNPS1	negative regulation of mRNA splicing, via spliceosome
REAC:R-HSA-8953854	0.00564646741329	0.555555555556	TRA2B ACIN1 CWC22 RNPS1 SRSF10	Metabolism of RNA
GO:0050686	0.00655807506899	0.333333333333	ACIN1 SRSF10 RNPS1	negative regulation of mRNA processing
GO:1903311	0.00669909318912	0.555555555556	TRA2B ACIN1 CWC22 RNPS1 SRSF10	regulation of mRNA metabolic process
GO:0033119	0.0106791414882	0.333333333333	ACIN1 SRSF10 RNPS1	negative regulation of RNA splicing
GO:0000398	0.011418023714	0.555555555556	TRA2B ACIN1 CWC22 RNPS1 SRSF10	mRNA splicing, via spliceosome
GO:0000377	0.011418023714	0.555555555556	TRA2B ACIN1 CWC22 RNPS1 SRSF10	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0000375	0.0122982783461	0.555555555556	TRA2B ACIN1 CWC22 RNPS1 SRSF10	RNA splicing, via transesterification reactions
WP:WP4148	0.0202568688475	0.222222222222	EPB41L1 EPB41L2	Splicing factor NOVA regulated synaptic proteins
GO:0006397	0.0358806003362	0.555555555556	TRA2B ACIN1 CWC22 RNPS1 SRSF10	mRNA processing
HPA:0080123	0.0435725850613	0.444444444444	ACIN1 EPB41L2 RNPS1 TRA2B	caudate; glial cells[High]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
EPB41L2	EPB41L1	0.999	0.076	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM
CWC22	EPB41L2	0.998	0.066	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
ACIN1	RNPS1	0.998	0.92	bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
RNPS1	TRA2B	0.997	0.976	bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM
CWC22	RNPS1	0.996	0.318	bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction
ACIN1	NKTR	0.996	0.362	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
RNPS1	SRSF10	0.996		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM
U2AF2	SRSF10	0.994		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM
U2AF2	TRA2B	0.994	0.9	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM
RNPS1	NKTR	0.994	0.316	bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only
RNPS1	U2AF2	0.993	0.882	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
RNPS1	EPB41L1	0.989	0.078	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only
ACIN1	EPB41L1	0.983	0.064	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only
RNPS1	VANGL1	0.982	0.116	bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
ACIN1	U2AF2	0.98	0.73	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM
EPB41L1	VANGL1	0.975	0.102	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only
SRSF10	TRA2B	0.975		bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM
EPB41L2	ACIN1	0.973	0.092	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
ACIN1	SRSF10	0.968		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM
EPB41L2	RNPS1	0.967	0.068	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
CWC22	ACIN1	0.964	0.304	bioplex_WMM bioplex3_WMM youn_WMM fraction treiber_WMM
CWC22	EPB41L1	0.962	0.038	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
NKTR	TRA2B	0.898	0.254	bioplex_WMM bioplex3_WMM WMM_only boldt_WMM
NKTR	SRSF10	0.89		bioplex_WMM bioplex3_WMM WMM_only boldt_WMM
U2AF2	VANGL1	0.817	0.156	bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
ACIN1	TRA2B	0.77	0.814	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM
CWC22	SRSF10	0.623		bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM
CWC22	TRA2B	0.593	0.534	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
CWC22	NKTR	0.508	0.206	bioplex_WMM bioplex3_WMM WMM_only
EPB41L2	VANGL1	0.463	0.222	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
U2AF2	NKTR	0.459	0.31	bioplex_WMM bioplex3_WMM WMM_only
CWC22	U2AF2	0.428	0.334	bioplex_WMM bioplex3_WMM youn_WMM fraction treiber_WMM
ACIN1	VANGL1	0.369	0.198	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
CWC22	VANGL1	0.294	0.094	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
NKTR	VANGL1	0.271	0.13	bioplex_WMM bioplex3_WMM WMM_only
EPB41L1	SRSF10	0.183		bioplex_WMM bioplex3_WMM WMM_only
EPB41L2	TRA2B	0.084	0.068	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
EPB41L2	SRSF10	0.082		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
SRSF10	VANGL1	0.072		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
EPB41L1	NKTR	0.049	0.106	bioplex3_WMM WMM_only
TRA2B	VANGL1	0.044	0.102	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
EPB41L1	TRA2B	0.024	0.114	bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
EPB41L2	NKTR	0.022	0.054	bioplex3_WMM WMM_only
EPB41L1	U2AF2	0.004	0.198727272727	bioplex3_WMM gupta_WMM WMM_only
EPB41L2	U2AF2	0.002	0.168	bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM

Related Complexes

Genename	Complexes
CWC22	huMAP3_00373.1 huMAP3_00489.1 huMAP3_07467.1 huMAP3_08365.1 huMAP3_08647.1 huMAP3_09637.1 huMAP3_09803.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_11077.1 huMAP3_11931.1 huMAP3_12350.1
EPB41L2	huMAP3_00373.1 huMAP3_00489.1 huMAP3_00734.1 huMAP3_08365.1 huMAP3_08647.1 huMAP3_09637.1 huMAP3_09803.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_11077.1 huMAP3_11493.1
NKTR	huMAP3_00489.1 huMAP3_01312.1 huMAP3_02739.1 huMAP3_04339.1 huMAP3_05069.1 huMAP3_05740.1 huMAP3_06097.1 huMAP3_06219.1 huMAP3_06799.1 huMAP3_07248.1 huMAP3_07309.1 huMAP3_07835.1 huMAP3_08302.1 huMAP3_08365.1 huMAP3_08769.1 huMAP3_09226.1 huMAP3_09621.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_10789.1 huMAP3_11073.1 huMAP3_11261.1
ACIN1	huMAP3_00373.1 huMAP3_00489.1 huMAP3_02739.1 huMAP3_03253.1 huMAP3_05722.1 huMAP3_06097.1 huMAP3_06219.1 huMAP3_07248.1 huMAP3_08365.1 huMAP3_08745.1 huMAP3_08769.1 huMAP3_09621.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_10564.1 huMAP3_11073.1
SRSF10	huMAP3_00489.1 huMAP3_04780.1 huMAP3_06081.1 huMAP3_06097.1 huMAP3_06391.1 huMAP3_07267.1 huMAP3_07848.1 huMAP3_08467.1 huMAP3_08486.1 huMAP3_09532.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_11073.1
TRA2B	huMAP3_00489.1 huMAP3_03452.1 huMAP3_04780.1 huMAP3_05748.1 huMAP3_06097.1 huMAP3_06391.1 huMAP3_06975.1 huMAP3_07267.1 huMAP3_07659.1 huMAP3_08467.1 huMAP3_09587.1 huMAP3_09621.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10564.1 huMAP3_11073.1
RNPS1	huMAP3_00373.1 huMAP3_00489.1 huMAP3_02739.1 huMAP3_03253.1 huMAP3_05722.1 huMAP3_06097.1 huMAP3_07248.1 huMAP3_07267.1 huMAP3_07291.1 huMAP3_08365.1 huMAP3_08745.1 huMAP3_08769.1 huMAP3_09621.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_10564.1 huMAP3_11073.1
VANGL1	huMAP3_00489.1 huMAP3_06097.1 huMAP3_08365.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_12350.1
U2AF2	huMAP3_00398.1 huMAP3_00442.1 huMAP3_00489.1 huMAP3_06097.1 huMAP3_07248.1 huMAP3_07835.1 huMAP3_08360.1 huMAP3_09621.1 huMAP3_09637.1 huMAP3_09943.1 huMAP3_11073.1
EPB41L1	huMAP3_00373.1 huMAP3_00489.1 huMAP3_00734.1 huMAP3_01025.1 huMAP3_06097.1 huMAP3_08082.1 huMAP3_08647.1 huMAP3_09181.1 huMAP3_09637.1 huMAP3_09803.1 huMAP3_09943.1 huMAP3_10250.1 huMAP3_11077.1 huMAP3_12829.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_00489.1