hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00492.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PAK6 | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | 5 | UniProt NCBI |
| PAK4 | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-428540 | 0.000133283416666 | 1.0 | PAK6 PAK4 | Activation of RAC1 |
| WP:WP4564 | 0.000238782367243 | 1.0 | PAK6 PAK4 | Neural crest cell migration during development |
| WP:WP4565 | 0.000268151321502 | 1.0 | PAK6 PAK4 | Neural crest cell migration in cancer |
| WP:WP4534 | 0.000331996874241 | 1.0 | PAK6 PAK4 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| KEGG:05211 | 0.000338144964505 | 1.0 | PAK6 PAK4 | Renal cell carcinoma |
| KEGG:04012 | 0.000463323629249 | 1.0 | PAK6 PAK4 | ErbB signaling pathway |
| WP:WP4205 | 0.000679316681139 | 1.0 | PAK6 PAK4 | MET in type 1 papillary renal cell carcinoma |
| KEGG:04660 | 0.000853978605069 | 1.0 | PAK6 PAK4 | T cell receptor signaling pathway |
| REAC:R-HSA-9013407 | 0.000958615342944 | 1.0 | PAK6 PAK4 | RHOH GTPase cycle |
| REAC:R-HSA-9013424 | 0.00101671324252 | 1.0 | PAK6 PAK4 | RHOV GTPase cycle |
| WP:WP4263 | 0.00137906393915 | 1.0 | PAK6 PAK4 | Pancreatic adenocarcinoma pathway |
| WP:WP673 | 0.00137906393915 | 1.0 | PAK6 PAK4 | ErbB signaling pathway |
| WP:WP185 | 0.00148377064565 | 1.0 | PAK6 PAK4 | Integrin mediated cell adhesion |
| KEGG:04360 | 0.00191523357059 | 1.0 | PAK6 PAK4 | Axon guidance |
| WP:WP4541 | 0.00194090480325 | 1.0 | PAK6 PAK4 | Hippo Merlin signaling dysregulation |
| KEGG:04510 | 0.00241871191437 | 1.0 | PAK6 PAK4 | Focal adhesion |
| KEGG:04014 | 0.00273702337615 | 1.0 | PAK6 PAK4 | Ras signaling pathway |
| KEGG:05170 | 0.0030120912992 | 1.0 | PAK6 PAK4 | Human immunodeficiency virus 1 infection |
| KEGG:04810 | 0.00307500577096 | 1.0 | PAK6 PAK4 | Regulation of actin cytoskeleton |
| WP:WP51 | 0.0034595776844 | 1.0 | PAK6 PAK4 | Regulation of actin cytoskeleton |
| WP:WP4223 | 0.00456751084292 | 1.0 | PAK6 PAK4 | Ras signaling |
| WP:WP306 | 0.00633262755764 | 1.0 | PAK6 PAK4 | Focal adhesion |
| REAC:R-HSA-9013148 | 0.013456498798 | 1.0 | PAK6 PAK4 | CDC42 GTPase cycle |
| REAC:R-HSA-9013149 | 0.0211937720117 | 1.0 | PAK6 PAK4 | RAC1 GTPase cycle |
| WP:WP5087 | 0.0293715080819 | 1.0 | PAK6 PAK4 | Pleural mesothelioma |
| REAC:R-HSA-376176 | 0.0374987766505 | 1.0 | PAK6 PAK4 | Signaling by ROBO receptors |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PAK6 | PAK4 | 0.966 | 0.115529411765 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| PAK6 | huMAP3_00492.1 huMAP3_08705.1 huMAP3_11881.1 huMAP3_14454.1 |
| PAK4 | huMAP3_00492.1 huMAP3_08705.1 huMAP3_12105.1 huMAP3_12737.1 huMAP3_13353.1 huMAP3_14454.1 huMAP3_14794.1 |