hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00502.1
Complex Portal: CPX-15919
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAC2 | Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2) | 5 | UniProt NCBI |
| DOCK3 | Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP) | 5 | UniProt NCBI |
| ELMO1 | Engulfment and cell motility protein 1 (Protein ced-12 homolog) | 5 | UniProt NCBI |
| DOCK2 | Dedicator of cytokinesis protein 2 | 5 | UniProt NCBI |
| ELMO3 | Engulfment and cell motility protein 3 | 3 | UniProt NCBI |
| DOCK4 | Dedicator of cytokinesis protein 4 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5341 | 1.36501667663e-05 | 0.4 | ELMO1 DOCK2 | ELMO1-DOCK2 complex |
| REAC:R-HSA-9013408 | 0.000148520473584 | 0.6 | DOCK3 DOCK4 DOCK2 | RHOG GTPase cycle |
| REAC:R-HSA-9013404 | 0.000284390695808 | 0.6 | DOCK3 DOCK4 DOCK2 | RAC2 GTPase cycle |
| REAC:R-HSA-164944 | 0.000319009353903 | 0.4 | ELMO1 DOCK2 | Nef and signal transduction |
| REAC:R-HSA-983231 | 0.00194346431817 | 0.6 | DOCK3 DOCK4 DOCK2 | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-9013149 | 0.0019808748776 | 0.6 | DOCK3 DOCK4 DOCK2 | RAC1 GTPase cycle |
| GO:0005085 | 0.00388246947083 | 0.8 | DOCK2 DOCK3 DOCK4 ELMO1 | guanyl-nucleotide exchange factor activity |
| REAC:R-HSA-164952 | 0.00531742996423 | 0.4 | ELMO1 DOCK2 | The role of Nef in HIV-1 replication and disease pathogenesis |
| KEGG:05100 | 0.0128243509281 | 0.4 | ELMO1 ELMO3 | Bacterial invasion of epithelial cells |
| REAC:R-HSA-9012999 | 0.0303172193635 | 0.6 | DOCK3 DOCK4 DOCK2 | RHO GTPase cycle |
| WP:WP3929 | 0.0420114386662 | 0.4 | ELMO1 DOCK2 | Chemokine signaling pathway |
| KEGG:04062 | 0.0427854405203 | 0.4 | ELMO1 DOCK2 | Chemokine signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ELMO1 | DOCK4 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ELMO3 | DOCK4 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ELMO1 | DOCK3 | 0.999 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ELMO3 | DOCK3 | 0.999 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DOCK2 | ELMO3 | 0.993 | 0.112 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DOCK4 | DOCK3 | 0.99 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| ELMO1 | ELMO3 | 0.982 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAC2 | ELMO3 | 0.966 | 0.180711111111 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAC2 | DOCK4 | 0.952 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| RAC2 | ELMO1 | 0.916 | 0.24 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DOCK2 | DOCK3 | 0.902 | 0.1 | bioplex3_WMM WMM_only | |
| DOCK2 | DOCK4 | 0.869 |
mutually_exclusive (Q92556)
|
bioplex3_WMM WMM_only | |
| RAC2 | DOCK3 | 0.587 | 0.256 | bioplex3_WMM WMM_only | |
| RAC2 | DOCK2 | 0.133 | 0.262 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
| ELMO1 | DOCK2 | 0.055 | 0.328 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
Related Complexes