hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00503.1
Complex Portal: CPX-22993
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| XRCC6 | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | 5 | UniProt NCBI |
| LIG4 | DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) | 5 | UniProt NCBI |
| XRCC5 | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03450 | 0.0176678729005 | 1.0 | LIG4 | Non-homologous end-joining |
| CORUM:213 | 0.0249718442455 | 1.0 | LIG4 | DNA ligase IV-XRCC1 complex |
| WP:WP438 | 0.0408901513344 | 1.0 | LIG4 | Non homologous end joining |
| CORUM:206 | 0.0499436884912 | 1.0 | LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:344 | 0.0499436884912 | 1.0 | LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:345 | 0.0499436884912 | 1.0 | LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:348 | 0.0499436884912 | 1.0 | LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:352 | 0.0499436884912 | 1.0 | LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:354 | 0.0499436884912 | 1.0 | LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:359 | 0.0499436884912 | 1.0 | LIG4 | DNA ligase IV-XRCC4-XLF complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| XRCC6 | XRCC5 | 1.0 | 0.96 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| LIG4 | XRCC6 | 0.982 | 0.418 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () boldt_WMM | |
| LIG4 | XRCC5 | 0.916 | 0.398 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM WMM_only |
Related Complexes