hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_00518.1

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
DOLK	Dolichol kinase (EC 2.7.1.108) (Transmembrane protein 15)	5	UniProt NCBI
TRADD	Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain)	5	UniProt NCBI
TNFRSF1A	Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]	5	UniProt NCBI
TNF	Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6347	2.05032700758e-05	0.666666666667	TRADD TNF	TNF-R1 signaling complex
WP:WP2513	7.47269756116e-05	0.666666666667	TRADD TNF	Nanoparticle triggered regulated necrosis
WP:WP5182	0.000103023242897	0.666666666667	TRADD TNF	Pro survival signaling of neuroprotectin D1
WP:WP262	0.000261425039751	0.666666666667	TRADD TNF	Ebstein Barr virus LMP1 signaling
CORUM:6344	0.000310824382464	0.666666666667	TRADD TNF	TNF-R1-associated signaling complex
KEGG:04920	0.0014867141158	0.666666666667	TRADD TNF	Adipocytokine signaling pathway
WP:WP5039	0.00149859190216	0.666666666667	TRADD TNF	SARS CoV 2 innate immunity evasion and cell specific immune response
KEGG:04622	0.00158324752529	0.666666666667	TRADD TNF	RIG-I-like receptor signaling pathway
WP:WP3865	0.0016171107809	0.666666666667	TRADD TNF	Novel intracellular components of RIG I like receptor pathway
REAC:R-HSA-5357786	0.00188000535098	0.666666666667	TRADD TNF	TNFR1-induced proapoptotic signaling
KEGG:04657	0.00222598019504	0.666666666667	TRADD TNF	IL-17 signaling pathway
KEGG:04064	0.0024036675985	0.666666666667	TRADD TNF	NF-kappa B signaling pathway
WP:WP254	0.00296720799434	0.666666666667	TRADD TNF	Apoptosis
REAC:R-HSA-5357956	0.0033773260227	0.666666666667	TRADD TNF	TNFR1-induced NF-kappa-B signaling pathway
KEGG:04668	0.00339398898617	0.666666666667	TRADD TNF	TNF signaling pathway
WP:WP231	0.0039339723602	0.666666666667	TRADD TNF	TNF alpha signaling pathway
KEGG:04071	0.00399150940056	0.666666666667	TRADD TNF	Sphingolipid signaling pathway
KEGG:04210	0.00542112539104	0.666666666667	TRADD TNF	Apoptosis
KEGG:04936	0.00578906402762	0.666666666667	TRADD TNF	Alcoholic liver disease
REAC:R-HSA-5357905	0.00643790104829	0.666666666667	TRADD TNF	Regulation of TNFR1 signaling
KEGG:05160	0.00646184763568	0.666666666667	TRADD TNF	Hepatitis C
KEGG:04217	0.00706776241177	0.666666666667	TRADD TNF	Necroptosis
KEGG:05164	0.00780874825616	0.666666666667	TRADD TNF	Influenza A
KEGG:05152	0.00802719593767	0.666666666667	TRADD TNF	Tuberculosis
REAC:R-HSA-75893	0.00937397262456	0.666666666667	TRADD TNF	TNF signaling
KEGG:05130	0.0102516009655	0.666666666667	TRADD TNF	Pathogenic Escherichia coli infection
KEGG:05169	0.0121980359765	0.666666666667	TRADD TNF	Epstein-Barr virus infection
KEGG:05163	0.0138758373086	0.666666666667	TRADD TNF	Human cytomegalovirus infection
KEGG:05170	0.0140204887763	0.666666666667	TRADD TNF	Human immunodeficiency virus 1 infection
KEGG:05132	0.0188728482722	0.666666666667	TRADD TNF	Salmonella infection
KEGG:05131	0.0193802248568	0.666666666667	TRADD TNF	Shigellosis
KEGG:04010	0.0221986078054	0.666666666667	TRADD TNF	MAPK signaling pathway
KEGG:05165	0.0324411425615	0.666666666667	TRADD TNF	Human papillomavirus infection
REAC:R-HSA-4755583	0.0498224659464	0.333333333333	DOLK	Defective DOLK causes DOLK-CDG
CORUM:5540	0.0499402709677	0.333333333333	TRADD	TRAF2-TRADD complex
CORUM:6684	0.0499402709677	0.333333333333	TNF	TNFR2 signaling complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
TRADD	TNFRSF1A	0.992	0.1	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
TNFRSF1A	TNF	0.991		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
DOLK	TNFRSF1A	0.977	0.174	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
TRADD	TNF	0.333		bioplex_WMM bioplex3_WMM WMM_only
DOLK	TRADD	0.165	0.042	bioplex_WMM bioplex3_WMM WMM_only
DOLK	TNF	0.165		bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
DOLK	huMAP3_00518.1 huMAP3_01042.1 huMAP3_08542.1 huMAP3_09410.1 huMAP3_09697.1 huMAP3_10986.1
TRADD	huMAP3_00518.1 huMAP3_04210.1 huMAP3_05879.1 huMAP3_08046.1 huMAP3_09800.1 huMAP3_10986.1 huMAP3_11190.1 huMAP3_11556.1 huMAP3_13095.1
TNFRSF1A	huMAP3_00518.1 huMAP3_05879.1 huMAP3_08046.1 huMAP3_08828.1 huMAP3_09800.1 huMAP3_10986.1
TNF	huMAP3_00518.1 huMAP3_08046.1 huMAP3_08081.1 huMAP3_08828.1 huMAP3_09328.1 huMAP3_09800.1 huMAP3_10986.1 huMAP3_12026.1 huMAP3_13736.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_00518.1