hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00521.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LDHB | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | 5 | UniProt NCBI |
| LDHC | L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X) | 5 | UniProt NCBI |
| LDHAL6A | L-lactate dehydrogenase A-like 6A (LDHA-like protein 6A) (EC 1.1.1.27) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00640 | 2.34814991651e-07 | 1.0 | LDHB LDHAL6A LDHC | Propanoate metabolism |
| KEGG:00620 | 6.44683384198e-07 | 1.0 | LDHB LDHAL6A LDHC | Pyruvate metabolism |
| KEGG:00270 | 7.92990338881e-07 | 1.0 | LDHB LDHAL6A LDHC | Cysteine and methionine metabolism |
| GO:0004457 | 9.61200410764e-07 | 1.0 | LDHB LDHAL6A LDHC | lactate dehydrogenase activity |
| GO:0004459 | 9.61200410764e-07 | 1.0 | LDHB LDHAL6A LDHC | L-lactate dehydrogenase activity |
| REAC:R-HSA-70268 | 1.89440469306e-06 | 1.0 | LDHB LDHAL6A LDHC | Pyruvate metabolism |
| KEGG:00010 | 1.97568475734e-06 | 1.0 | LDHB LDHAL6A LDHC | Glycolysis / Gluconeogenesis |
| KEGG:05230 | 2.50251661292e-06 | 1.0 | LDHB LDHAL6A LDHC | Central carbon metabolism in cancer |
| KEGG:04922 | 6.56019280347e-06 | 1.0 | LDHB LDHAL6A LDHC | Glucagon signaling pathway |
| GO:0006089 | 8.07408345042e-06 | 1.0 | LDHB LDHAL6A LDHC | lactate metabolic process |
| KEGG:04066 | 8.19365887109e-06 | 1.0 | LDHB LDHAL6A LDHC | HIF-1 signaling pathway |
| REAC:R-HSA-71406 | 1.03119073194e-05 | 1.0 | LDHB LDHAL6A LDHC | Pyruvate metabolism and Citric Acid (TCA) cycle |
| WP:WP4236 | 8.83096676097e-05 | 0.666666666667 | LDHB LDHC | Krebs cycle disorders |
| REAC:R-HSA-1428517 | 0.000368729542429 | 1.0 | LDHB LDHAL6A LDHC | The citric acid (TCA) cycle and respiratory electron transport |
| WP:WP534 | 0.000973512535349 | 0.666666666667 | LDHB LDHC | Glycolysis and gluconeogenesis |
| WP:WP4018 | 0.0031328951477 | 0.666666666667 | LDHB LDHC | Clear cell renal cell carcinoma pathways |
| WP:WP5355 | 0.00412431213363 | 0.666666666667 | LDHB LDHC | Metabolic Epileptic Disorders |
| GO:0006090 | 0.0105478288276 | 1.0 | LDHB LDHAL6A LDHC | pyruvate metabolic process |
| GO:0016616 | 0.0165038110528 | 1.0 | LDHB LDHAL6A LDHC | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| KEGG:01100 | 0.0189521995452 | 1.0 | LDHB LDHAL6A LDHC | Metabolic pathways |
| GO:0016614 | 0.0207446272651 | 1.0 | LDHB LDHAL6A LDHC | oxidoreductase activity, acting on CH-OH group of donors |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LDHB | LDHC | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LDHC | LDHAL6A | 0.974 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LDHB | LDHAL6A | 0.069 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes